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1. リウマチ性多発筋痛の臨床症状および診断 clinical manifestations and diagnosis of polymyalgia rheumatica
2. 再発性多発性軟骨炎の臨床症状 clinical manifestations of relapsing polychondritis
3. 全身性疾患のミオパシー myopathies of systemic disease
4. 巨細胞（側頭）動脈炎の臨床症状 clinical manifestations of giant cell temporal arteritis

The rate of polymyalgia rheumatica (PMR) and remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome in a clinic where primary care physicians are working in Japan.

Okumura T, Tanno S, Ohhira M, Nozu T.SourceDepartment of General Medicine, Asahikawa Medical University, 2-1-1 Midorigaoka-Higashi, Asahikawa, 078-8510, Japan. okumurat@asahikawa-med.ac.jp
Rheumatology international.Rheumatol Int.2012 Jun;32(6):1695-9. Epub 2011 Mar 24.
We analyzed the rate of polymyalgia rheumatica (PMR) and remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome, both characterized as seronegative inflammatory arthritis in elderly, in an outpatient unit where primary care physicians are working in Japan to better understa
PMID 21431946

High serum matrix metalloproteinase 3 is characteristic of patients with paraneoplastic remitting seronegative symmetrical synovitis with pitting edema syndrome.

Origuchi T, Arima K, Kawashiri SY, Tamai M, Yamasaki S, Nakamura H, Tsukada T, Aramaki T, Furuyama M, Miyashita T, Kawabe Y, Iwanaga N, Terada K, Ueki Y, Fukuda T, Eguchi K, Kawakami A.SourceDepartment of Rehabilitation Sciences, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 852-8520, Japan, origuchi@nagasaki-u.ac.jp.
Modern rheumatology / the Japan Rheumatism Association.Mod Rheumatol.2011 Nov 17. [Epub ahead of print]
Recently, it was reported that remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome could be complicated with solid tumors. In a retrospective, multicenter study between October, 2003 and September, 2010, we investigated the characteristics of patients with paraneoplastic
PMID 22089392

Remitting seronegative symmetrical synovitis with pitting edema（RS3PE）症候群様症状で発症した肺癌の1切除例

濱中瑠利香,村上修司,横瀬智之,中山治彦,山田耕三,岩崎正之
肺癌 51(4), 253-258, 2011
… 背景．Remitting seronegative symmetrical synovitis with pitting edema（RS3PE）症候群は腫瘍随伴症候群の一つとして知られているが，肺癌に合併した報告は稀である．RS3PE症候群様症状で発症し,外科的切除を施行することで症状軽快を認めた肺癌の1例につき報告する．症例．79歳，男性．2009年12月頃から両下肢と足背の浮腫を認め，次第に手指と両手関節の腫脹，手関節と足関節の熱感，疼痛を自覚した．2010年4月 …
NAID 130000954004

Monitoring of therapeutic efficacy in a patient with RS(3)PE syndrome by serologic variables and radiographic methods.

Kawashiri Shin-Ya,Nakano Michiko,Kawakami Atsushi,Eguchi Katsumi
Rheumatology international 30(12), 1677-1680, 2010-11
… We describe a typical case of a patient with remitting seronegative symmetrical synovitis and pitting edema (RS(3)PE) syndrome. … Our present case supports a previous observation that synovial tissue is a major inflammatory source of RS(3)PE syndrome. … IL-6 (and VEGF), probably produced from the synovial tissues, are considered to be essential factors in the development of RS(3)PE syndrome. …
NAID 120001657507