WordNet

very offensive in smell or taste; "a rank cigar"
relative status; "his salary was determined by his rank and seniority"
a row or line of people (especially soldiers or police) standing abreast of one another; "the entrance was guarded by ranks of policemen"
take precedence or surpass others in rank (同)outrank
growing profusely; "rank jungle vegetation"
take or have a position relative to others; "This painting ranks among the best in the Western World"
very fertile; producing profuse growth; "rank earth"

PrepTutorEJDIC

〈C〉〈U〉『階級』,等級;)相対的な)『順位』,地位: / 〈U〉高い地位(身分) / 〈C〉〈U〉(人・物の)『列』,並び;(兵隊)の横列 / 《the ranks》(また『rank and file』)(将校たちに対して)兵卒,下士官 / …‘を'『並べる』 / …‘を'『位置づける』,評価する / 《米》…‘より'上位にある / 『位置する』・「pull one's rank on 誰々」で「(誰々に)地位を悪用する; (意見が衝突したような場合に)階級をかさに着て(誰々に)命令を押しつける」
(植物が)おい茂った,はびこった / (土地が)植物をおい茂らせた,肥えすぎた;(土地が)(植物を)おい茂らせた《+『with』+『名』》 / 悪臭を放つ,いやな味のする / 全くの,ひどい
Regular Army正規軍

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/05 20:54:36」(JST)

wiki en

[Wiki en表示]

Not to be confused with RANKL, the osteoclast cell-surface receptor that binds to RANK.

For other uses, see Rank (disambiguation).

Receptor Activator of Nuclear Factor κ B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is also expressed on dendritic cells and facilitates immune signaling.

RANKL (Receptor Activator for Nuclear Factor κ B Ligand) is found on the surface of stromal cells, osteoblasts, and T cells. ^[1] ^[2] ^[3]

Interactions[edit]

RANK has been shown to interact with TRAF6,^[4]^[5]^[6]^[7]^[8] TRAF5,^[5]^[6]^[7] TRAF1,^[7]^[8] TRAF2^[5]^[6]^[7]^[8] and TRAF3.^[7]^[8]

References[edit]

^ Suda T, Takahashi N, Udagawa N, Jimi E, Gillespie MT, Martin TJ (1999). "Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families". Endocr. Rev. 20 (3): 345–57. doi:10.1210/er.20.3.345. PMID 10368775.
^ Wong BR, Josien R, Choi Y (1999). "TRANCE is a TNF family member that regulates dendritic cell and osteoclast function". J. Leukoc. Biol. 65 (6): 715–24. PMID 10380891.
^ Theill LE, Boyle WJ, Penninger JM (2002). "RANK-L and RANK: T cells, bone loss, and mammalian evolution". Annu. Rev. Immunol. 20: 795–823. doi:10.1146/annurev.immunol.20.100301.064753. PMID 11861618.
^ Mizukami, Junko; Takaesu Giichi, Akatsuka Hiroyuki, Sakurai Hiroaki, Ninomiya-Tsuji Jun, Matsumoto Kunihiro, Sakurai Naoki (Feb 2002). "Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6". Mol. Cell. Biol. (United States) 22 (4): 992–1000. doi:10.1128/MCB.22.4.992-1000.2002. ISSN 0270-7306. PMC 134634. PMID 11809792. Cite uses deprecated parameters (help)
^ ^a ^b ^c Darnay, B G; Haridas V, Ni J, Moore P A, Aggarwal B B (Aug 1998). "Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase". J. Biol. Chem. (UNITED STATES) 273 (32): 20551–5. doi:10.1074/jbc.273.32.20551. ISSN 0021-9258. PMID 9685412. Cite uses deprecated parameters (help)
^ ^a ^b ^c Darnay, B G; Ni J, Moore P A, Aggarwal B B (Mar 1999). "Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif". J. Biol. Chem. (UNITED STATES) 274 (12): 7724–31. doi:10.1074/jbc.274.12.7724. ISSN 0021-9258. PMID 10075662. Cite uses deprecated parameters (help)
^ ^a ^b ^c ^d ^e Galibert, L; Tometsko M E, Anderson D M, Cosman D, Dougall W C (Dec 1998). "The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily". J. Biol. Chem. (UNITED STATES) 273 (51): 34120–7. doi:10.1074/jbc.273.51.34120. ISSN 0021-9258. PMID 9852070. Cite uses deprecated parameters (help)
^ ^a ^b ^c ^d Kim, H H; Lee D E, Shin J N, Lee Y S, Jeon Y M, Chung C H, Ni J, Kwon B S, Lee Z H (Jan 1999). "Receptor activator of NF-kappaB recruits multiple TRAF family adaptors and activates c-Jun N-terminal kinase". FEBS Lett. (NETHERLANDS) 443 (3): 297–302. doi:10.1016/S0014-5793(98)01731-1. ISSN 0014-5793. PMID 10025951. Cite uses deprecated parameters (help)

External links[edit]

RANK Protein at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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1. 骨粗鬆症に対するデノスマブdenosumab for osteoporosis [show details]
…function of bone-resorbing osteoclasts. RANKL interacts with a receptor (RANK) on both osteoclast precursors and osteoclasts. The RANKL/RANK interaction results in activation, migration, differentiation, and …
2. 骨格の正常な発達および骨形成ならびに骨吸収の調節normal skeletal development and regulation of bone formation and resorption [show details]
… precursors that is identical to the receptor involved in interaction of T-cells and dendritic cells called RANK NFATc1 is induced by RANKL and coactivated by immunoglobulin-like receptors and their associated …
3. 骨転移の機序mechanisms of bone metastases [show details]
…cells can activate osteoclastic bone resorption in a number of ways. The receptor activator of nuclear factor kappa-B (RANK)/RANK ligand (RANKL) signaling pathway is a major regulator of both normal and …
4. 骨の巨大細胞腫瘍giant cell tumor of bone [show details]
…treatment with denosumab. The characterization of the role of the RANK (receptor activator of nuclear factor kappa B [NF-kB])/RANK ligand (RANKL) axis in mediating the recruitment and function of osteoclast-like …
5. 多発性骨髄腫：病理生物学的特徴multiple myeloma pathobiology [show details]
…activating factors such as lymphotoxin, IL-6, hepatocyte growth factor, and receptor activator of nuclear factor kappa B ligand (RANK ligand). Renal involvement in MM is usually the result of monoclonal …

English Journal

Long-term outcome of patients with liver cirrhosis admitted to a general intensive care unit.

Warren A1, Soulsby CR1, Puxty A2, Campbell J1, Shaw M3, Quasim T1,2, Kinsella J1, McPeake J4,5.
Annals of intensive care.Ann Intensive Care.2017 Dec;7(1):37. doi: 10.1186/s13613-017-0257-6. Epub 2017 Apr 4.
PMID 28374334

IL-6 rs1800795 polymorphism is associated with septic shock-related death in patients who underwent major surgery: a preliminary retrospective study.

Jiménez-Sousa MA1, Medrano LM2, Liu P3, Fernández-Rodríguez A2, Almansa R4, Gomez-Sanchez E3, Ortega A4, Heredia-Rodríguez M3, Gómez-Pesquera E3, Tamayo E3, Resino S5.
Annals of intensive care.Ann Intensive Care.2017 Dec;7(1):22. doi: 10.1186/s13613-017-0247-8. Epub 2017 Feb 28.
PMID 28247301

MLAA-based attenuation correction of flexible hardware components in hybrid PET/MR imaging.

Heußer T1, Rank CM2, Berker Y3,4, Freitag MT5, Kachelrieß M2.
EJNMMI physics.EJNMMI Phys.2017 Dec;4(1):12. doi: 10.1186/s40658-017-0177-4. Epub 2017 Mar 1.
PMID 28251575

Japanese Journal

Validity of a Self-Administered Food-Frequency Questionnaire for Assessing Amino Acid Intake in Japan: Comparison With Intake From 4-Day Weighed Dietary Records and Plasma Levels

Iwasaki Motoki,Ishihara Junko,Takachi Ribeka,Todoriki Hidemi,Yamamoto Hiroshi,Miyano Hiroshi,Yamaji Taiki,Tsugane Shoichiro
Journal of Epidemiology advpub(0), 2016
… Plasma levels of amino acids were measured using the UF-Amino Station system.<BR>Results: Spearman rank correlation coefficients of energy-adjusted intake of amino acids from the DR and FFQ ranged from 0.40 to 0.65 for men and from 0.35 to 0.46 for women. …
NAID 130005092274

疾患からみた細胞表面機能分子(第5回)骨破壊におけるRANK/RANKL

中島友紀
分子リウマチ治療 8(3), 158-162, 2015-08
NAID 40020545201

Effectiveness of Approximation Strategy in Surrogateassisted Fireworks Algorithm

Pei Yan,Zheng Shaoqiu,Tan Ying,Takagi Hideyuki
International Journal of Machine Learning and Cybernetics 2015(7), 2015-07-14
… The advantages of the fireworks algorithm, a number of open topics, and new discoveries arising from evaluation results, such as multi-production mechanism of the fireworks algorithm, optimization performance of each method, elite rank, interpolation times and extrapolation times of elites are analyzed and discussed. …
NAID 120005624070

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★リンクテーブル★

リンク元	「NFκB活性化受容体」「receptor activator of nuclear factor-kappaB」
拡張検索	「RANKL」「RANKリガンド」
関連記事	「rank」「RA」

「NFκB活性化受容体」

Tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1LB5
Identifiers
Symbols	TNFRSF11A; CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7; OSTS; PDB2; RANK; TRANCER
External IDs	OMIM: 603499 MGI: 1314891 HomoloGene: 2848 GeneCards: TNFRSF11A Gene
Gene Ontology
Molecular function	• receptor activity; • transmembrane signaling receptor activity; • tumor necrosis factor-activated receptor activity; • protein binding; • cytokine binding; • metal ion binding;
Cellular component	• external side of plasma membrane; • integral to membrane;
Biological process	• adaptive immune response; • monocyte chemotaxis; • signal transduction; • cell-cell signaling; • positive regulation of cell proliferation; • osteoclast differentiation; • response to lipopolysaccharide; • tumor necrosis factor-mediated signaling pathway; • response to cytokine stimulus; • response to tumor necrosis factor; • positive regulation of I-kappaB kinase/NF-kappaB cascade; • positive regulation of JUN kinase activity; • positive regulation of sequence-specific DNA binding transcription factor activity; • positive regulation of NF-kappaB transcription factor activity; • circadian temperature homeostasis; • response to interleukin-1; • positive regulation of fever generation by positive regulation of prostaglandin secretion; • TNFSF11-mediated signaling pathway; • positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling;
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RNA expression pattern
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Orthologs
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