クロルゾキサゾン
WordNet
- used as a direction in music; to be played relatively loudly (同)loudly
- (music) loud (同)fortissimo
- an asset of special worth or utility; "cooking is his forte" (同)strong_suit, long_suit, metier, specialty, speciality, strong point, strength
- the stronger part of a sword blade between the hilt and the foible
- used chiefly as a direction or description in music; "the forte passages in the composition" (同)loud
PrepTutorEJDIC
- 得意なもの(こと),おはこ
- (音楽の演奏で)強音の,フォルテの / 強く(《略》『f』)
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/08/13 20:44:20」(JST)
[Wiki en表示]
Chlorzoxazone
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| Systematic (IUPAC) name |
|
5-chloro-3H-benzooxazol-2-one
|
| Clinical data |
| Trade names |
Parafonforte |
| AHFS/Drugs.com |
Monograph |
| MedlinePlus |
a682577 |
Routes of
administration |
oral |
| Pharmacokinetic data |
| Bioavailability |
well absorbed |
| Protein binding |
13–18% |
| Metabolism |
hepatic |
| Biological half-life |
1.1 hr |
| Excretion |
urine (<1%) |
| Identifiers |
| CAS Number |
95-25-0 Y |
| ATC code |
M03BB03 (WHO) |
| PubChem |
CID 2733 |
| IUPHAR/BPS |
2322 |
| DrugBank |
DB00356 Y |
| ChemSpider |
2632 Y |
| UNII |
H0DE420U8G Y |
| KEGG |
D00771 Y |
| ChEBI |
CHEBI:3655 Y |
| ChEMBL |
CHEMBL1371 Y |
| Chemical data |
| Formula |
C7H4ClNO2 |
| Molar mass |
169.565 g/mol |
|
|
InChI
-
InChI=1S/C7H4ClNO2/c8-4-1-2-6-5(3-4)9-7(10)11-6/h1-3H,(H,9,10) Y
-
Key:TZFWDZFKRBELIQ-UHFFFAOYSA-N Y
|
| (verify) |
Chlorzoxazone (INN) is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes. It is sold under the trade names "Lorzone", Paraflex and Muscol and in combination form as Parafon Forte, a combination of chlorzoxazone and acetaminophen (paracetamol). Possible side effects include dizziness, lightheadedness, malaise, nausea, vomiting, and liver dysfunction. Used with acetaminophen it has added risk of hepatoxicity,[medical citation needed] which is why the combination is not recommended. It can also be administered for acute pain in general and for tension headache (muscle contraction headache).
As of 2015 the cost for a typical course of medication in the United States is less than 25 USD.[1]
See also
References
- ^ Hamilton, Richart (2015). Tarascon Pocket Pharmacopoeia 2015 Deluxe Lab-Coat Edition. Jones & Bartlett Learning. p. 1. ISBN 9781284057560.
- D.F. Marsh, U.S. Patent 2,895,877 (1959).
- Dong DL, Luan Y, Feng TM, Fan CL, Yue P, Sun ZJ, Gu RM, Yang BF (2006). "Chlorzoxazone inhibit contraction of rat thoracic aorta". Eur J Pharmacol. 545 (2–3): 161–6. doi:10.1016/j.ejphar.2006.06.063. PMID 16859676.
- Park J, Kim K, Park P, Ha J (2006). "Effect of high-dose aspirin on CYP2E1 activity in healthy subjects measured using chlorzoxazone as a probe". J Clin Pharmacol. 46 (1): 109–14. doi:10.1177/0091270005282635. PMID 16397290.
- Wan J, Ernstgård L, Song B, Shoaf S (2006). "Chlorzoxazone metabolism is increased in fasted Sprague-Dawley rats". J Pharm Pharmacol. 58 (1): 51–61. doi:10.1211/jpp.58.1.0007. PMC 1388188. PMID 16393464.
- PARAFON DSC (chlorzoxazone) tablet, Daily Med, U.S. National Library of Medicine
|
Skeletal muscle relaxants (M03)
|
|
Peripherally acting
(primarily antinicotinic,
NMJ block) |
|
Non-depolarizing
|
|
Curare alkaloids
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- Alcuronium
- Dimethyltubocurarine
- Tubocurarine
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|
|
4° ammonium agents
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- ultra-short duration: Gantacurium
- short duration: Mivacurium
- Chandonium
- intermediate duration: Atracurium
- Cisatracurium
- Fazadinium
- Rocuronium
- Vecuronium
- long duration: Doxacurium
- Dimethyltubocurarine
- Pancuronium
- Pipecuronium
- Laudexium
- Gallamine
- unsorted: Hexafluronium (Hexafluorenium)
|
|
|
|
Depolarizing
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- Choline derivatives: Suxamethonium (Succinylcholine)
- Polyalkylene derivatives: Hexamethonium
|
|
|
ACh release inhibitors
|
|
|
|
| Centrally acting |
|
Carbamic acid esters
|
- Carisoprodol
- Cyclarbamate
- Difebarbamate
- Febarbamate
- Meprobamate
- Phenprobamate
- Styramate
- Tybamate
|
|
|
Benzodiazepines
|
- Bromazepam
- Diazepam
- Clonazepam
- Flunitrazepam
- Lorazepam
- Nitrazepam
- Temazepam
- Tetrazepam
|
|
|
Nonbenzodiazepines
|
|
|
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Thienodiazepines
|
|
|
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Quinazolines
|
|
|
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Anticholinergics
(Antimuscarinics)
|
- Cyclobenzaprine
- Orphenadrine
|
|
|
Other
|
- Arbaclofen placarbil
- Baclofen
- Chlormezanone
- Chlorphenesin
- Chlorzoxazone
- Donepezil
- Eperisone
- Fenyramidol
- Flopropione
- Gabapentin
- GHB
- Inaperisone
- Lanperisone
- Mephenesin
- Mephenoxalone
- Metaxalone
- Methocarbamol
- Phenibut
- Pregabalin
- Pridinol
- Promoxolane
- Quinine
- Silperisone
- Thiocolchicoside
- Tizanidine
- Tolperisone
- Zoxazolamine
|
|
|
| Directly acting |
|
UpToDate Contents
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- 1. 急性腰痛の治療 treatment of acute low back pain
- 2. 律動眼振 jerk nystagmus
English Journal
- Two chlorzoxazone (Parafon forte) overdoses and coma in one patient: reversal with flumazenil.
- Roberge RJ1, Atchley B, Ryan K, Krenzelok EP.
- The American journal of emergency medicine.Am J Emerg Med.1998 Jul;16(4):393-5.
- PMID 9672460
- Chlorzoxazone hepatotoxic reactions. An analysis of 21 identified or presumed cases.
- Powers BJ, Cattau EL Jr, Zimmerman HJ.
- Archives of internal medicine.Arch Intern Med.1986 Jun;146(6):1183-6.
- A drug rechallenge proved chlorzoxazone to be hepatotoxic in a patient who had been treated with a combination of it and acetaminophen (Parafon Forte) for several months. Failure to demonstrate a toxic response to acetaminophen coupled with a dramatic response to a single dose of chlorzoxazone impli
- PMID 3521519
- Parafon Forte versus Robaxisal in skeletal muscle disorders: a double-blind study.
- Gready DM.
- Current therapeutic research, clinical and experimental.Curr Ther Res Clin Exp.1976 Nov;20(5):666-73.
- PMID 825352
Related Links
- Learn about the prescription medication Parafon Forte (Chlorzoxazone), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. ... Hands-On Treatment May Help Low Back Pain » "Medscape ...
- What is the most important information I should know about chlorzoxazone (Parafon Forte)? Before taking chlorzoxazone, tell your doctor if you have liver disease. You may need a lower dose or special monitoring during therapy. This ...
★リンクテーブル★
[★]
- 英
- chlorzoxazone
- ラ
- chlorzoxazonum
- 商
- スラックシン、Par flex, Parafon Forte
- 関
- 脊髄反射、骨格筋弛緩剤
中枢性筋弛緩薬