English Journal
- The Function of Arf-like Proteins ARL2 and ARL3 in Photoreceptors.
- Hanke-Gogokhia C1,2, Zhang H3, Frederick JM4, Baehr W5,6,7.
- Advances in experimental medicine and biology.Adv Exp Med Biol.2016;854:655-61. doi: 10.1007/978-3-319-17121-0_87.
- Arf-like proteins (ARLs) are ubiquitously expressed small G proteins of the RAS superfamily. In photoreceptors, ARL2 and ARL3 participate in the trafficking of lipidated membrane-associated proteins and colocalize in the inner segment with UNC119A and PDEδ. UNC119A and PDEδ are acyl- and prenyl-bi
- PMID 26427472
- Tauroursodeoxycholic Acid Protects Retinal Function and Structure in rd1 Mice.
- Lawson EC1,2, Bhatia SK3,4, Han MK5, Aung MH6,7, Ciavatta V8,9, Boatright JH10, Pardue MT11,12.
- Advances in experimental medicine and biology.Adv Exp Med Biol.2016;854:431-6. doi: 10.1007/978-3-319-17121-0_57.
- We explored the potential protective effects of tauroursodeoxycholic acid (TUDCA) on cone photoreceptor survival in a model of rapid retinal degeneration, the ß-Pde6 (rd1) (rd1) mouse model. We injected two strains of rd1 mice (B6.C3-Pde6b (rd1) Hps4(le)/J and C57BL/6J-Pde6b (rd1-2)/J mice) daily f
- PMID 26427442
- Long-term rescue of cone photoreceptor degeneration in retinitis pigmentosa 2 (RP2)-knockout mice by gene replacement therapy.
- Mookherjee S1, Hiriyanna S1, Kaneshiro K1, Li L2, Li Y1, Li W1, Qian H1, Li T1, Khanna H2, Colosi P1, Swaroop A3, Wu Z3.
- Human molecular genetics.Hum Mol Genet.2015 Nov 15;24(22):6446-58. doi: 10.1093/hmg/ddv354. Epub 2015 Sep 10.
- Retinal neurodegenerative diseases are especially attractive targets for gene replacement therapy, which appears to be clinically effective for several monogenic diseases. X-linked forms of retinitis pigmentosa (XLRP) are relatively severe blinding disorders, resulting from progressive photoreceptor
- PMID 26358772
Japanese Journal
- 2P-211 カエル視細胞のcGMP分解酵素PDE6の二つのγサブユニットは機能分担を行っている(光生物-視覚・光受容,第47回日本生物物理学会年会)
- Saito Natsumi,Hayashi Fumio
- 生物物理 49(SUPPLEMENT_1), S140, 2009-09-20
- NAID 110008101787
- The pharmacology of sildenafil, a novel and selective inhibitor of phosphodiesterase (PDE) type 5 (第27回薬物活性シンポジウム講演要旨集)
- Wallis R.M.
- 日本薬理学雑誌 114(supplement), 22-26, 1999
- … 3.5 nM) and is selective over PDEI to 4 (80 to 19, 000-fold) and retinal PDE6 (10-fold). … As a consequence of inhibition of PDE6 in the retina, sildenafil (1 to 100 μM) altered the kinetics of the light response of the dog isolated retina. …
- NAID 130000754512
- Rolipram, a Selective Inhibitor of Phosphodiesterase Type 4, Pronouncedly Enhanced the Forskolin-Induced Promotion of Dopamine Biosynthesis in Primary Cultured Rat Mesencephalic Neurons
- Yamashita Nobuyuki,Miyashiro Mio,Baba Jun [他],SAWA Aiko
- The Japanese journal of pharmacology 75(1), 91-95, 1997-09-01
- … Selective inhibitors of PDE2, PDE3, PDE5 and PDE6 did not have such a promoting effect, and the PDE1 inhibitor vinpocetine and W-7 caused dopamine depletion in the neurons. …
- NAID 10008679845
Related Links
- 15 Feb 2002 ... Membrane-associated bovine rod PDE6 was prepared from frozen bovine retinas and purified by using the ion exchange, immunoaffinity, and gel filtration chromatography procedures described previously (33). Bovine Pαβ ...
Related Pictures
★リンクテーブル★
| リンク元 | 「ホスホジエステラーゼ6」「phosphodiesterase 6」 |
| 関連記事 | 「PD」「PDE」 |
「ホスホジエステラーゼ6」
「phosphodiesterase 6」
「PD」
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