- 関
- phosphodiesterase 6
English Journal
- The Function of Arf-like Proteins ARL2 and ARL3 in Photoreceptors.
- Hanke-Gogokhia C1,2, Zhang H3, Frederick JM4, Baehr W5,6,7.
- Advances in experimental medicine and biology.Adv Exp Med Biol.2016;854:655-61. doi: 10.1007/978-3-319-17121-0_87.
- Arf-like proteins (ARLs) are ubiquitously expressed small G proteins of the RAS superfamily. In photoreceptors, ARL2 and ARL3 participate in the trafficking of lipidated membrane-associated proteins and colocalize in the inner segment with UNC119A and PDEδ. UNC119A and PDEδ are acyl- and prenyl-bi
- PMID 26427472
- Tauroursodeoxycholic Acid Protects Retinal Function and Structure in rd1 Mice.
- Lawson EC1,2, Bhatia SK3,4, Han MK5, Aung MH6,7, Ciavatta V8,9, Boatright JH10, Pardue MT11,12.
- Advances in experimental medicine and biology.Adv Exp Med Biol.2016;854:431-6. doi: 10.1007/978-3-319-17121-0_57.
- We explored the potential protective effects of tauroursodeoxycholic acid (TUDCA) on cone photoreceptor survival in a model of rapid retinal degeneration, the ß-Pde6 (rd1) (rd1) mouse model. We injected two strains of rd1 mice (B6.C3-Pde6b (rd1) Hps4(le)/J and C57BL/6J-Pde6b (rd1-2)/J mice) daily f
- PMID 26427442
- Long-term rescue of cone photoreceptor degeneration in retinitis pigmentosa 2 (RP2)-knockout mice by gene replacement therapy.
- Mookherjee S1, Hiriyanna S1, Kaneshiro K1, Li L2, Li Y1, Li W1, Qian H1, Li T1, Khanna H2, Colosi P1, Swaroop A3, Wu Z3.
- Human molecular genetics.Hum Mol Genet.2015 Nov 15;24(22):6446-58. doi: 10.1093/hmg/ddv354. Epub 2015 Sep 10.
- Retinal neurodegenerative diseases are especially attractive targets for gene replacement therapy, which appears to be clinically effective for several monogenic diseases. X-linked forms of retinitis pigmentosa (XLRP) are relatively severe blinding disorders, resulting from progressive photoreceptor
- PMID 26358772
Japanese Journal
- 2P-211 カエル視細胞のcGMP分解酵素PDE6の二つのγサブユニットは機能分担を行っている(光生物-視覚・光受容,第47回日本生物物理学会年会)
- Saito Natsumi,Hayashi Fumio
- 生物物理 49(SUPPLEMENT_1), S140, 2009-09-20
- NAID 110008101787
- The pharmacology of sildenafil, a novel and selective inhibitor of phosphodiesterase (PDE) type 5 (第27回薬物活性シンポジウム講演要旨集)
- Wallis R.M.
- 日本薬理学雑誌 114(supplement), 22-26, 1999
- … 3.5 nM) and is selective over PDEI to 4 (80 to 19, 000-fold) and retinal PDE6 (10-fold). … As a consequence of inhibition of PDE6 in the retina, sildenafil (1 to 100 μM) altered the kinetics of the light response of the dog isolated retina. …
- NAID 130000754512
- Rolipram, a Selective Inhibitor of Phosphodiesterase Type 4, Pronouncedly Enhanced the Forskolin-Induced Promotion of Dopamine Biosynthesis in Primary Cultured Rat Mesencephalic Neurons
- Yamashita Nobuyuki,Miyashiro Mio,Baba Jun [他],SAWA Aiko
- The Japanese journal of pharmacology 75(1), 91-95, 1997-09-01
- … Selective inhibitors of PDE2, PDE3, PDE5 and PDE6 did not have such a promoting effect, and the PDE1 inhibitor vinpocetine and W-7 caused dopamine depletion in the neurons. …
- NAID 10008679845
Related Links
- 15 Feb 2002 ... Membrane-associated bovine rod PDE6 was prepared from frozen bovine retinas and purified by using the ion exchange, immunoaffinity, and gel filtration chromatography procedures described previously (33). Bovine Pαβ ...
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★リンクテーブル★
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- 英
- phosphodiesterase 6、PDE6
- 関
- 6型サイクリックヌクレオチドホスホジエステラーゼ
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ホスホジエステラーゼ6
- 関
- PDE6、type 6 cyclic nucleotide phosphodiesterase
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ホスホジエステラーゼ phosphodiesterase