WordNet

invest with or as with a body; give body to (同)personify
the external structure of a vehicle; "the body of the car was badly rusted"
the main mass of a thing
a natural object consisting of a dead animal or person; "they found the body in the lake" (同)dead body
the entire structure of an organism (an animal, plant, or human being); "he felt as if his whole body were on fire" (同)organic structure, physical structure
a collection of particulars considered as a system; "a body of law"; "a body of doctrine"; "a body of precedents"
a group of persons associated by some common tie or occupation and regarded as an entity; "the whole body filed out of the auditorium"; "the student body"; "administrative body"
an individual 3-dimensional object that has mass and that is distinguishable from other objects; "heavenly body"
the central message of a communication; "the body of the message was short"

PrepTutorEJDIC

〈C〉『身体』,肉体 / 〈C〉(人・動物の)『胴体』 / 〈C〉)物の)『主要部』,本体《+『of』+『名』》 / 〈C〉(…の)『団体』,群れ:(…のたくさんの)集まり《+『of』+『名』》 / 〈C〉物体,…体 / 〈U〉実質;(酒・味などの)こく / 〈C〉《話》人
《英話》人;(特に)男

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/12 20:10:34」(JST)

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Red arrows indicate secreted lamellar granules, and green arrows indicate lamellar granules in the cytoplasm. Scale bar = 200 nm.

Lamellar granules (otherwise known as membrane-coating granules (MCGs), lamellar bodies, keratinosomes or Odland bodies) are secretory organelles found in type II pneumocytes and keratinocytes. They are oblong structures, appearing about 300-400 nm in width and 100-150 nm in length in transmission electron microscopy images. Lamellar granules fuse with the cell membrane and release their contents into the extracellular space.^[1]

Role in lungs

In pneumocytes, the choline-based phospholipids that are stored in the lamellar bodies serve as pulmonary surfactant after being released from the cell.

Role in epidermis

In the upper spinous layer and stratum granulosum layer of the epidermis, lamellar bodies are secreted from keratinocytes, resulting in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function. These granules release components that are required for skin shedding (desquamation) in the uppermost epidermal layer, the stratum corneum.^[2] These components include lipids (e.g. glucosylceramides), hydrolytic enzymes (e.g. proteases, acid phosphatases, glucosidases, lipases) and proteins (e.g. corneodesmosin).^[3] Lamellar granules have been observed to contain distinct aggregates of the secreted components glucosylceramide, cathepsin D, KLK7, KLK8 and corneodesmosin. Transportation of molecules via lamellar granules is thought to prevent enzymes from interacting with their relevant substrates or inhibitors prior to secretion.^[3]

Recent work suggests that lamellar granules form a continuous membranous structure with the trans-Golgi network

Lamellar body secretion and lipid structure is abnormal in the epidermis of patients with Netherton syndrome, a skin disorder characterised by chronic inflammation and universal pruritus (itch).^[4]

References

^ Ishida-Yamamoto A, Kishibe M. (Mar 2011). "Involvement of corneodesmosome degradation and lamellar granule transportation in the desquamation process.". Med Mel Morphol. 44 (1): 1–6. doi:10.1007/s00795-010-0513-4. PMID 21424930.
^ Descargues P, Deraison C, Bonnart C, Kreft M, Kishibe M, Ishida-Yamamoto A, Elias P, Barrandon Y, Zambruno G, Sonnenberg A, Hovnanian A. (Jan 2005). "Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity.". Nat Genet 37 (1): 56–65. doi:10.1038/ng1493. PMID 15619623.
^ ^a ^b Ishida-Yamamoto A, Simon M, Kishibe M, Miyauchi Y, Takahashi H, Yoshida S, O'Brien TJ, Serre G, Iizuka H. (May 2004). "Epidermal lamellar granules transport different cargoes as distinct aggregates.". J Invest Dermatol. 122 (5): 1137–44. doi:10.1111/j.0022-202x.2004.22515.x. PMID 15140216.
^ Fartasch M, Williams ML, Elias PM. (Jul 1999). "Altered lamellar body secretion and stratum corneum membrane structure in Netherton syndrome: differentiation from other infantile erythrodermas and pathogenic implications.". Arch Dermatol. 135 (7): 823–32. doi:10.1001/archderm.135.7.823. PMID 10411158.

External links

Dr. Jastrow's Electron microscopic atlas
EM at meddean.luc.edu
"Lamellar body" at Dorland's Medical Dictionary

UpToDate Contents

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English Journal

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Nilsson LM1, Berner J, Dudarev AA, Mulvad G, Odland JØ, Parkinson A, Rautio A, Tikhonov C, Evengård B.
International journal of circumpolar health.Int J Circumpolar Health.2013 Aug 7;72. doi: 10.3402/ijch.v72i0.21530. Print 2013.
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Plasma levels of apolipoprotein-E in residents of the European North of Russia.

Kaneva AM1, Bojko ER, Potolitsyna NN, Odland JO.
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Hanssen L1, Warner NA, Braathen T, Odland JØ, Lund E, Nieboer E, Sandanger TM.
Environment international.Environ Int.2013 Jan;51:82-7. doi: 10.1016/j.envint.2012.10.008. Epub 2012 Nov 28.
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PMID 23201819

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Related Pictures

Oral mucous membrane Oral epithelium , dr naveen reddy Gingival keratinization ppt Histology of skin and its appendages. 가온경희한의원에 오신것을 환영합니다. Bodies O-R - Pathological and non-pathological bodies Odland body .Seen in stratum granulosum | Dermatology, Body, Membrane