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English Journal

Central P2Y12 receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents.

Horváth G1, Gölöncsér F1, Csölle C1, Király K2, Andó RD3, Baranyi M3, Koványi B1, Máté Z4, Hoffmann K5, Algaier I5, Baqi Y6, Müller CE7, Von Kügelgen I5, Sperlágh B8.
Neurobiology of disease.Neurobiol Dis.2014 Oct;70:162-78. doi: 10.1016/j.nbd.2014.06.011. Epub 2014 Jun 25.
In this study the role of P2Y12 receptors (P2Y12R) was explored in rodent models of inflammatory and neuropathic pain and in acute thermal nociception. In correlation with their activity to block the recombinant human P2Y12R, the majority of P2Y12R antagonists alleviated mechanical hyperalgesia dose
PMID 24971933

RGS4 is involved in the generation of abnormal involuntary movements in the unilateral 6-OHDA-lesioned rat model of Parkinson's disease.

Ko WK1, Martin-Negrier ML2, Bezard E2, Crossman AR3, Ravenscroft P3.
Neurobiology of disease.Neurobiol Dis.2014 Oct;70:138-48. doi: 10.1016/j.nbd.2014.06.013. Epub 2014 Jun 24.
Regulators of G-protein signalling (RGS) proteins are implicated in striatal G-protein coupled receptor (GPCR) sensitisation in the pathophysiology of l-DOPA-induced abnormal involuntary movements (AIMs), also known as dyskinesia (LID), in Parkinson's disease (PD). In this study, we investigated RGS
PMID 24969021

NMDA receptor antagonism potentiates the l-DOPA-induced extracellular dopamine release in the subthalamic nucleus of hemi-parkinson rats.

El Arfani A1, Bentea E2, Aourz N3, Ampe B4, De Deurwaerdère P5, Van Eeckhaut A6, Massie A7, Sarre S8, Smolders I9, Michotte Y10.
Neuropharmacology.Neuropharmacology.2014 Oct;85:198-205. doi: 10.1016/j.neuropharm.2014.05.024. Epub 2014 May 24.
Long term treatment with L-3,4-dihydroxyphenylalanine (l-DOPA) is associated with several motor complications. Clinical improvement of this treatment is therefore needed. Lesions or high frequency stimulation of the hyperactive subthalamic nucleus (STN) in Parkinson's disease (PD), alleviate the mot
PMID 24863042

A Case of Primary Mucosa-Associated Lymphoid Tissue Type Lymphoma of the Gallbladder

The Usefulness of Computed Tomographic Colonography for Colorectal Cancer in the Elderly

Therapeutic Effects of Multifunctional Tetramethylpyrazine Nitrone on Models of Parkinson's Disease in Vitro and in Vivo

Guo Baojian,Xu Daping,Duan Hongwei [他],Du Jing,Zhang Zaijun,Lee Simon MingYuen,Wang Yuqiang
Biological and Pharmaceutical Bulletin 37(2), 274-285, 2014
… In the MPTP-induced mouse and 6-hydroxydopamine (6-OHDA)-induced rat PD models, TBN administrated orally twice daily for 14 d (3 d post-MPTP lesion in mice and 7 d post-6-OHDA lesion in rats) exhibited remarkable neurorescue effects to increase the number of dopaminergic neurons. … In addition, TBN improved apomorphine-induced rotational behavior in the 6-OHDA-lesioned PD rats. …
NAID 130003382123