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DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats.

Sun SY, An CN, Pu XP.SourceState Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, PR China; Department of Molecular and Cellular Pharmacology, School of Pharmaceutical Sciences, Peking Universit, Beijing 100191, PR China.
Brain research bulletin.Brain Res Bull.2012 Sep 1;88(6):609-16. Epub 2012 Jun 1.
Parkinson disease (PD) is the second most common neurodegenerative disease, and it cannot be completely cured by current medications. In this study, DJ-1 protein was administrated into medial forebrain bundle of PD model rats those had been microinjected with 6-hydroxydopamine (6-OHDA) or MG-132. We
PMID 22664331

Neuroprotection by neuropeptide Y in cell and animal models of Parkinson's disease.

Decressac M, Pain S, Chabeauti PY, Frangeul L, Thiriet N, Herzog H, Vergote J, Chalon S, Jaber M, Gaillard A.SourceInstitut de Physiologie et Biologie Cellulaires, Université de Poitiers, Centre National de la Recherche Scientifique (CNRS), Poitiers, France.
Neurobiology of aging.Neurobiol Aging.2012 Sep;33(9):2125-37. Epub 2011 Aug 3.
This study was aimed to investigate the potential neuroprotective effect of neuropeptide Y (NPY) on the survival of dopaminergic cells in both in vitro and in animal models of Parkinson's disease (PD). NPY protected human SH-SY5Y dopaminergic neuroblastoma cells from 6-hydroxydopamine-induced toxici
PMID 21816512

Protection Against Dopaminergic Neurodegeneration in Parkinson’s Disease–Model Animals by a Modulator of the Oxidized Form of DJ-1, a Wild-type of Familial Parkinson’s Disease–Linked PARK7

Inden Masatoshi,Kitamura Yoshihisa,Takahashi Kazunori,Takata Kazuyuki,Ito Natsuko,Niwa Rina,Funayama Risa,Nishimura Kaneyasu,Taniguchi Takashi,Honda Toshio,Taira Takahiro,Ariga Hiroyoshi
Journal of Pharmacological Sciences 117(3), 189-203, 2011
DJ-1, Parkinson’s disease PARK7, acts as an oxidative stress sensor in neural cells. Recently, we identified the DJ-1 modulator UCP0054278 by in silico virtual screening. However, the effect of the pe …
NAID 130001380971

Excessive Expression of Hippocampal Ezrin Is Induced by Intrastriatal Injection of 6-Hydroxydopamine

Matsumoto Yosuke,Murakami Hiroki,Hattori Naoki,Yoshimoto Kanji,Asano Shinji,Inden Masatoshi
Biological & Pharmaceutical Bulletin 34(11), 1753-1758, 2011
… The purpose of the present study is to examine whether the expression level of ERM proteins in the hippocampus is changed by an intrastriatal injection of 6-hydroxydopamine (6-OHDA) in mice. …
NAID 130001252861

Tonic Inhibition of Allergic Itch Signaling by the Descending Noradrenergic System in Mice

Gotoh Yoshikazu,Omori Yu,Andoh Tsugunobu,Kuraishi Yasushi
Journal of Pharmacological Sciences 115(3), 417-420, 2011
… The biting was increased by intrathecal pretreatment with the catecholaminergic neurotoxin 6-hydroxydopamine and the α-adrenoceptor antagonist phentolamine but not the serotonergic neurotoxin 5,7-dihydroxytryptamine. …
NAID 130000663405