関: 6-hydroxydopamine、oxidopamine

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/19 10:49:06」(JST)

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Oxidopamine, also known as 6-hydroxydopamine (6-OHDA) or 2,4,5-trihydroxyphenethylamine, is a neurotoxic synthetic organic compound used by researchers to selectively destroy dopaminergic and noradrenergic neurons in the brain. 6-OHDA is thought to enter the neurons via the dopamine and noradrenaline (norepinephrine) reuptake transporters. Oxidopamine is often used in conjunction with a selective noradrenaline reuptake inhibitor (such as desipramine) to selectively destroy dopaminergic neurons only.

The main use for oxidopamine in scientific research is to induce Parkinsonism in laboratory animals such as mice, rats and monkeys, in order to develop and test new medicines and treatments for Parkinson's disease. In order to induce this condition in animals, around 70% of the dopaminergic neurons in the substantia nigra of the brain must be destroyed, and this is achieved either with oxidopamine or MPTP. Both these agents likely destroy neurons by generating reactive oxygen species such as superoxide radical. Oxidopamine toxicity in neonatal rodents is also used as an animal model for the Lesch-Nyhan syndrome.^[1]

References[edit]

^ Breese GR, Knapp DJ, Criswell HE, Moy SS, Papadeas ST, Blake BL (2005). "The neonate-6-hydroxydopamine-lesioned rat: a model for clinical neuroscience and neurobiological principles". Brain Res. Brain Res. Rev. 48 (1): 57–73. doi:10.1016/j.brainresrev.2004.08.004. PMID 15708628.

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English Journal

High frequency electro-acupuncture enhances striatum DAT and D1 receptor expression, but decreases D2 receptor level in 6-OHDA lesioned rats.

Rui G, Guangjian Z, Yong W, Jie F, Yanchao C, Xi J, Fen L.SourceNuclear Medicine Department of The 1st Affiliated Hospital of Xi'an Jiao Tong University, China.
Behavioural brain research.Behav Brain Res.2013 Jan 15;237:263-9. doi: 10.1016/j.bbr.2012.09.047. Epub 2012 Oct 2.
The direct effects of electro-acupuncture (EA) on the dopaminergic neurotransmitter system in Parkinson's disease (PD) patients remain elusive. In the present study, 0, 2 or 100Hz EA was applied to acupoints Sanyinjiao (SP6), Yanglingquan (GB34) and Zusanli (ST36) in a rat model unilaterally lesione
PMID 23036843

Characterisation of spatial neglect induced by unilateral 6-OHDA lesions on a choice reaction time task in rats.

Heuer A, Dunnett SB.SourceBrain Repair Group, School of Bioscience, Cardiff University, Cardiff, Wales, UK. Electronic address: HeuerA@cf.ac.uk.
Behavioural brain research.Behav Brain Res.2013 Jan 15;237:215-22. doi: 10.1016/j.bbr.2012.09.038. Epub 2012 Sep 27.
Unilateral dopamine depletion and excitotoxic lesions of the striatum have been shown to induce a contralateral neglect when rats have to respond in a choice reaction time setting. Whereas, in a lateralised setting when response options are to either side of the animal's head all contralateral respo
PMID 23022749

Japanese Journal

Brain Science(103)パーキンソン病モデルにおける線条体遺伝子ネットワーク解析と治療薬による遺伝子発現修飾

植田勇人,小島俊男
精神科 21(3), 335-340, 2012-09
NAID 40019417721

成体期黒質損傷ラットにおける時間知覚の行動科学的検討 <論文>

氏田麻美,坂田省吾,ウジタアサミ,サカタショウゴ,Ujita Asami,Sakata Shogo
広島大学大学院総合科学研究科紀要. I, 人間科学研究 6, 1-11, 2011-12-31
… We studied the effects of an injection of 6-hydroxydopamine (6-OHDA) into the substantianigra of rats on the performance of timing behavior by using a peak interval (PI) procedure. … Then, subjects were divided into three groups: lesion (n=6), operational sham lesion (n=3) and intact (n=3). …
NAID 80022327864

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★リンクテーブル★

リンク元	「6-ヒドロキシドパミン」「6-hydroxydopamine」「oxidopamine」
関連記事	「OHDA」「OH」

「6-ヒドロキシドパミン」

Oxidopamine
	IUPAC name 5-(2-Aminoethyl)benzene-1,2,4-triol
Identifiers
CAS number	1199-18-4
PubChem	4624
ChemSpider	4463
UNII	8HW4YBZ748
KEGG	D05294
ChEMBL	CHEMBL337702
Jmol-3D images	Image 1
	SMILES c1c(c(cc(c1O)O)O)CCN ;
	InChI InChI=1S/C8H11NO3/c9-2-1-5-3-7(11)8(12)4-6(5)10/h3-4,10-12H,1-2,9H2 ; Key: DIVDFFZHCJEHGG-UHFFFAOYSA-N InChI=1/C8H11NO3/c9-2-1-5-3-7(11)8(12)4-6(5)10/h3-4,10-12H,1-2,9H2; Key: DIVDFFZHCJEHGG-UHFFFAOYAG ;
Properties
Molecular formula	C8H11NO3
Molar mass	169.18 g/mol
	(verify) (what is: /?); Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
	Infobox references