- 関
- neurokinin-2 receptor
WordNet
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- the 14th letter of the Roman alphabet (同)n
PrepTutorEJDIC
- =sense organ / 受信装置
- nitrogenの化学記号
UpToDate Contents
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- 1. ナチュラルキラー（NK）細胞大顆粒リンパ球性白血病natural killer nk cell large granular lymphocyte leukemia [show details]
…abnormalities during a transformation into a more acute NK cell LGL leukemia . There is skewed NK receptor expression on NK cells in patients with the natural killer (NK) type of lymphoproliferative disease of granular …
- 2. NK細胞欠損症候群：臨床症状および診断nk cell deficiency syndromes clinical manifestations and diagnosis [show details]
…families of inhibitory receptors on the surface of NK cells, including the killer cell Ig-like receptors (KIRs), act to restrain the destructive potential of these cells. Additional NK cell functions include …
- 3. 重度複合型免疫不全（SCID）：特定の欠損severe combined immunodeficiency scid specific defects [show details]
… cell-positive, NK-positive (T-B+NK+) SCID syndromes include defects in interleukin 7 receptor alpha chain (IL7RA; also called CD127); CD45 (also called protein-tyrosine phosphatase, receptor-type, C [PTPRC]); …
- 4. 原発性免疫不全症の診断のためのフローサイトメトリーflow cytometry for the diagnosis of primary immunodeficiencies [show details]
…subunits, CD45, or interleukin (IL) 7 receptor alpha (IL-7-R-alpha) result in T-B+NK+ SCID. Mutations in the recombinase-activating genes (RAG) or Artemis result in T-B-NK+ SCID. Mutations in adenosine deaminase …
- 5. T-B-NK+ SCID：臨床症状、診断、および治療t b nk scid clinical manifestations diagnosis and treatment [show details]
… normal range for the laboratory) Normal number and function of NK cells (at least 100 to 200/microL) Absent or very low T cell receptor excision circles (TRECs), as performed in newborn screening (NBS) …
English Journal
- Novel pituitary actions of TAC3 gene products in fish model: receptor specificity and signal transduction for prolactin and somatolactin α regulation by neurokinin B (NKB) and NKB-related peptide in carp pituitary cells.
- Hu G1, He M, Ko WK, Lin C, Wong AO.
- Endocrinology.Endocrinology.2014 Sep;155(9):3582-96. doi: 10.1210/en.2014-1105. Epub 2014 Jun 27.
- TAC3 is a member of tachykinins, and its gene product neurokinin B (NKB) has recently emerged as a key regulator for LH through modulation of kisspeptin/GnRH system within the hypothalamus. In fish models, TAC3 not only encodes NKB but also a novel tachykinin-like peptide called NKB-related peptide
- PMID 24971612
- Impaired colonic motility and reduction in tachykinin signalling in the aged mouse.
- Patel BA1, Patel N1, Fidalgo S1, Wang C2, Ranson RN3, Saffrey MJ2, Yeoman MS4.
- Experimental gerontology.Exp Gerontol.2014 May;53:24-30. doi: 10.1016/j.exger.2014.02.007. Epub 2014 Feb 18.
- Ageing is associated with an increased incidence of constipation in humans. The contribution that the ageing process makes to this condition is unclear. The aim of this study was to determine the effects of age on faecal output and colonic motility in male C57BL/6J mice and to determine the role tha
- PMID 24560671
- Plasma membrane translocation of REDD1 governed by GPCRs contributes to mTORC1 activation.
- Michel G1, Matthes HW, Hachet-Haas M, El Baghdadi K, de Mey J, Pepperkok R, Simpson JC, Galzi JL, Lecat S.
- Journal of cell science.J Cell Sci.2014 Feb 15;127(Pt 4):773-87. doi: 10.1242/jcs.136432. Epub 2013 Dec 11.
- The mTORC1 kinase promotes cell growth in response to growth factors by activation of receptor tyrosine kinase. It is regulated by the cellular energy level and the availability of nutrients. mTORC1 activity is also inhibited by cellular stresses through overexpression of REDD1 (regulated in develop
- PMID 24338366
Japanese Journal
- Effects of TAK-480, a Novel Tachykinin NK_2-Receptor Antagonist, on Visceral Hypersensitivity in Rabbits and Ricinoleic Acid-Induced Defecation in Guinea Pigs
- Tanaka Takahiro,Tanaka Akiko,Nakamura Akihiro [他],MATSUSHITA Kozo,IMANISHI Akio,MATSUMOTO OKANO Shiho,INATOMI Nobuhiro,MIURA Kasei,TOYODA Masao,MIZOJIRI Gaku,TSUKIMI Yasuhiro
- Journal of pharmacological sciences 120(1), 15-25, 2012-09-20
- … ethoxy)-<I>N</I>-((1<I>R</I>,2<I>S</I>)-2-(((3<I>aR</I>,4<I>R</I>,9<I>bR</I>)-4-(methoxymethyl)-2, 3,3<I>a</I>,4,5,9<I>b</I>-hexahydro-1<I>H</I>-pyrrolo[3,2-<I>c</I>]quinolin-1-yl)carbonyl)cyclohexyl)benzamide, is a novel tachykinin NK<SUB>2</SUB>–receptor …
- NAID 10031071815
- モルモット大腸粘膜からのタキキニンNK_2受容体作動性セロトニン放出に及ぼすメラトニンの効果
- Establishment and Validation of a Rabbit Model for In Vivo Pharmacodynamic Screening of Tachykinin NK_2 Antagonists
- Tanaka Takahiro,Matsumoto-Okano Shiho,Inatomi Nobuhiro [他],FUJIOKA Yasushi,KAMIGUCHI Hidenori,YAMAGUCHI Masashi,IMANISHI Akio,KAWAMOTO Makiko,MIURA Kasei,NISHIKAWA Yoichi,TSUKIMI Yasuhiro
- Journal of pharmacological sciences 118(4), 487-495, 2012-04-20
- … We attempted to establish and validate an in vivo pharmacodynamic (PD) rabbit model to screen tachykinin NK<SUB>2</SUB> … receptor (NK<SUB>2</SUB>-R) antagonists using pharmacological and pharmacokinetic (PK)/PD analyses. …
- NAID 10030572084
Related Links
- G-protein-coupled receptors, GPCRs, constitute a vast protein family that encompasses a wide range of functions (including various autocrine, paracrine and endocrine processes). They show considerable diversity at the sequence level, ...
- (1994). "Calcium influx and protein kinase C alpha activation mediate arachidonic acid mobilization by the human NK-2 receptor expressed in Chinese hamster ovary cells". FEBS Lett. 338 (1): 75–80. doi:10.1016/0014-5793(94) 80119-3.
★リンクテーブル★
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- 英
- neurokinin-2 receptor、NK-2 receptor
- 関
- ニューロキニン-2受容体、ニューロキニン-2レセプター、ニューロキニン2レセプター、NK-2受容体、NK-2レセプター
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- 関
- NK-2 receptor
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- 英
- NK-2 receptor
- 関
- ニューロキニン2受容体、NK-2レセプター
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- 英
- NK-2 receptor
- 関
- ニューロキニン2受容体、NK-2受容体
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