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N-terminal fusion of a toll-like receptor 2-ligand to a Neospora caninum chimeric antigen efficiently modifies the properties of the specific immune response.

Aguado-Martínez A1, Basto AP2, Müller J1, Balmer V1, Manser V1, Leitão A2, Hemphill A1.
Parasitology.Parasitology.2016 Apr;143(5):606-16. doi: 10.1017/S0031182016000056. Epub 2016 Mar 2.
Immunoprophylactic products against neosporosis during pregnancy should induce an appropriately balanced immune response. In this respect, OprI, a bacterial lipoprotein targeting toll like receptor (TLR)2, provides promising adjuvant properties. We report on the manipulation of the innate and the T-
PMID 26932317

Experimental Neospora Caninum Infection in Pregnant Dairy Heifers Raises Concentrations of Pregnancy-Associated Glycoproteins 1 and 2 in Foetal Fluids.

Mur-Novales R1, López-Gatius F2, Serrano-Pérez B1,2, García-Ispierto I1,2, Darwich L3,4, Cabezón O5, de Sousa NM6, Beckers JF6, Almería S3,4.
Reproduction in domestic animals = Zuchthygiene.Reprod Domest Anim.2016 Apr;51(2):282-6. doi: 10.1111/rda.12678. Epub 2016 Mar 3.
Plasma concentrations of PAG-1 are used for pregnancy diagnosis and as a marker of placental/foetal well-being, while those of PAG-2 may be an indicator of abortion risk in Neospora caninum-infected cows. Studies have shown that N. caninum infection modifies PAG-1 and PAG-2 patterns in maternal blo
PMID 26936628

Neospora caninum: Chronic and congenital infection in consecutive pregnancies of mice.

Mazuz ML1, Shkap V2, Wollkomirsky R2, Leibovich B2, Savitsky I2, Fleiderovitz L2, Noam S2, Elena B2, Molad T2, Golenser J3.
Veterinary parasitology.Vet Parasitol.2016 Mar 30;219:66-70. doi: 10.1016/j.vetpar.2016.01.013. Epub 2016 Jan 27.
Neospora caninum, the causative agent of bovine neosporosis is the major cause of abortion in cattle worldwide. The principal route of transmission is via in utero infection of the offspring. Congenitally-infected dams remain persistently infected for life and might undergo abortions in consecutive
PMID 26921042

Parasitology : Seroprevalences of Toxoplasma gondii and Neospora caninum in Pet Rabbits in Japan

Tracking Neospora caninum parasites using chimera monoclonal antibodies against its surface antigen-related sequences (rNcSRS2)

Tracking Neospora caninum parasites using chimera monoclonal antibodies against its surface antigen-related sequences (rNcSRS2)(CELL AND TISSUE ENGINEERING)

Dong Jinhua,Otsuki Takahiro,Kato Tatsuya,Park Enoch Y.
Journal of bioscience and bioengineering 117(3), 351-357, 2014-03
… Tracking of Neospora caninum parasite that is responsible for neosporosis is required for the prevention of this infectious disease. … caninum. … caninum was expressed in silkworm larvae, and immunized in mice to obtain phage displaying antibody library. … caninum strain Nc-Liv, demonstrating a successful tracking of the parasite. …
NAID 110009815389