関: Neospora caninum

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/20 08:04:01」(JST)

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Neospora is an important protozoan pathogen in cattle and dogs. It was not discovered until 1984 in Norway, where it was found in dogs. It is highly transmissible and some herds can have up to a 90% prevalence. Neospora causes abortions in cattle and up to 33% of pregnancies can result in aborted fetuses on one dairy farm. Diagnosis is hard because the parasite is not found in adults. The best way to detect the parasite is by its pathological effects on fetuses.

Life cycle

The life cycle is similar to Toxoplasma. An infected dog will pass the oocysts through its feces and infect food or water. A cow or other animal will then up take the parasite. The parasite will undergo asexual reproduction in the animal's muscle until it is eaten by a dog. There, sexual reproduction will occur and oocysts will be created and passed through the feces.

Epidemiology

Dogs are often the definitive host but can act as an intermediate host as well. Cows are usually the intermediate host. No horizontal cow-to-cow transmission have been shown, although salival interactions have been suggested. Vertical transmission can occur when an infected cow gives birth to an infected calf—the calf survives the infection and grows into an adult.

External links

Neospora at the US National Library of Medicine Medical Subject Headings (MeSH)

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English Journal

Evaluation of recombinant Neospora caninum antigens purified from silkworm larvae for the protection of N. caninum infection in mice.

Yoshimoto M1, Otsuki T1, Itagaki K1, Kato T2, Kohsaka T3, Matsumoto Y4, Ike K4, Park EY5.
Journal of bioscience and bioengineering.J Biosci Bioeng.2015 Dec;120(6):715-9. doi: 10.1016/j.jbiosc.2015.04.002. Epub 2015 Apr 29.
Three antigens (NcSAG1, NcSRS2 and NcMIC3) from Neospora caninum were expressed using the BmNPV bacmid system in silkworm larvae and purified from the hemolymph. From 20 silkworm larvae, 1.5, 1.2 and 1.4 mg of purified recombinant NcSAG1, NcSRS2 and NcMIC3 were obtained, respectively. When each pur
PMID 25935502

Activity of several kinds of drugs against Neospora caninum.

Qian W1, Wang H2, Shan D2, Li B2, Liu J2, Liu Q3.
Parasitology international.Parasitol Int.2015 Dec;64(6):597-602. doi: 10.1016/j.parint.2015.08.002. Epub 2015 Aug 8.
Neosporosis caused by Neospora caninum is a serious disease in cattle and dogs worldwide. It is the major cause of abortion and neonatal mortality in cattle. In this study, we evaluated the anti-N. caninum activity of Chinese medicine extracts (curcumin, artemether), herbicides (atrazine, glyphosate
PMID 26264260

Parasites and vector-borne diseases in client-owned dogs in Albania. Intestinal and pulmonary endoparasite infections.

Shukullari E1, Hamel D2,3, Rapti D1, Pfister K3, Visser M2, Winter R2, Rehbein S4.
Parasitology research.Parasitol Res.2015 Dec;114(12):4579-90. doi: 10.1007/s00436-015-4704-8. Epub 2015 Sep 8.
From March 2010 to April 2011 inclusive, feces from 602 client-owned dogs visiting four small animal clinics in Tirana, Albania, were examined using standard coproscopical techniques including Giardia coproantigen ELISA and immunofluorescent staining of Giardia cysts. Overall, samples of 245 dogs (4
PMID 26350379

Japanese Journal

A clinical case of neosporosis in a 4-week-old holstein friesian calf which developed hindlimb paresis postnatally

Ｔｈｅ　Ｊｏｕｒｎａｌ　ｏｆ　Ｖｅｔｅｒｉｎａｒｙ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅ 80(2), 280-283, 2018
NAID 130006386447

Transduction of a Neospora caninum antigen gene into mammalian cells using a modified Bombyx mori nucleopolyhedrovirus for antibody production

Journal of bioscience and bioengineering 124(6), 606-610, 2017-12
NAID 40021420017

Effects of Thai piperaceae plant extracts on Neospora caninum infection

Parasitology International 66(3), 219-226, 2017-01
NAID 120006390999

「ネオスポラ」

Neospora
Scientific classification
Domain:	Eukaryota
(unranked):	Sar
Superphylum:	Alveolata
Phylum:	Apicomplexa
Class:	Conoidasida
Subclass:	Coccidiasina
Order:	Eucoccidiorida
Family:	Sarcocystidae
Subfamily:	Toxoplasmatinae
Genus:	Neospora
Species
	Neospora caninum; Neospora hughesi