Mediterranean spotted fever

地中海紅斑熱、地中海斑点熱、Mediterranean紅斑熱

関

boutonneuse fever

WordNet

1. a rise in the temperature of the body; frequently a symptom of infection (同)febrility, febricity, pyrexia, feverishness
2. intense nervous anticipation; "in a fever of resentment"
3. of or relating to or characteristic of or located near the Mediterranean Sea; "Mediterranean countries"
4. the largest inland sea; between Europe and Africa and Asia (同)Mediterranean_Sea
5. highly excited; "a fevered imagination"

PrepTutorEJDIC

1. 〈U〉《しばしばa fever》(身体の異常な)『熱』,発熱 / 〈U〉『熱病』 / 〈U〉〈C〉(…に対する)『興奮』,熱狂《+『for』+『名』》
2. =Mediterranean Sea / 地中海地方 / 『地中海の』;地中海地方[の住民]特有の
3. (比較変化なし)《名詞の前にのみ用いて》熱のある,熱病にかかった / 熱にうかされたような,興奮した / (憎しみなどが)異常に強い
4. 斑点のある;汚点のついた

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/24 22:20:54」(JST)

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Boutonneuse fever
Typical eschar and spots on the leg of a patient with Boutonneuse fever
Classification and external resources
Specialty	Infectious disease
ICD-10	A77.1
ICD-9-CM	082.1
DiseasesDB	31780
MeSH	D001907

Boutonneuse fever (also called Mediterranean spotted fever, fièvre boutonneuse, Kenya tick typhus, Marseilles fever or African tick-bite fever) is a fever as a result of a Rickettsia infection caused by the bacterium Rickettsia conorii and transmitted by the dog tick Rhipicephalus sanguineus. Boutonneuse fever can be seen in many places around the world, although it is endemic in countries surrounding the Mediterranean Sea. This disease was first described in Tunisia in 1910 by Conor and Bruch and was named boutonneuse (French for "spotty") due to its papular skin rash characteristics.

Presentation

After an incubation period of around seven days, the disease manifests abruptly with chills, high fevers, muscular and articular pains, severe headache and photophobia. The location of the bite forms a black ulcerous crust (tache noire). Around the fourth day of the illness an exanthem (widespread rash) appears, first macular and then maculopapular and sometimes petechial.

Diagnosis

The diagnosis is made with serologic methods, either the classic Weil-Felix test (agglutination of Proteus OX strains ), ELISA or immunofluorescence assays in the bioptic material of the primary lesion.

Treatment

The illness can be treated with tetracyclines (doxycycline is the preferred treatment), chloramphenicol, macrolides or fluoroquinolones.

See also

• Rocky Mountain spotted fever

References

External links

• Mediterranean Spotted Fever Clinical Resources

UpToDate Contents

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• 1. その他の紅斑熱群リケッチア感染 other spotted fever group rickettsial infections
• 2. ロッキー山紅斑熱の臨床症状および診断 clinical manifestations and diagnosis of rocky mountain spotted fever
• 3. リケッチア痘瘡 rickettsialpox
• 4. 中央アフリカへの旅行によって感染する可能性のある疾患 diseases potentially acquired by travel to central africa
• 5. 小児における顔面神経麻痺 facial nerve palsy in children

English Journal

• Coxsackievirus A6-related hand foot and mouth disease: Skin manifestations in a cluster of adult patients.

• Ben-Chetrit E1, Wiener-Well Y2, Shulman LM3, Cohen MJ4, Elinav H4, Sofer D3, Feldman I2, Marva E4, Wolf DG4.Author information 1Shaare Zedek Medical Center Affiliated with the Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Electronic address: elibc1@yahoo.com.2Shaare Zedek Medical Center Affiliated with the Hadassah-Hebrew University Medical Center, Jerusalem, Israel.3Public Health Services, Israel Ministry of Health, Sheba Medical Center, Tel Hashomer 52621, Israel.4Hadassah-Hebrew University Medical Center, Jerusalem, Israel.AbstractBACKGROUND: Hand foot and mouth disease (HFMD) is a common childhood manifestation of enterovirus (EV) infection. It predominantly affects young children, and has been mainly associated with coxsackievirus (CV) A16 and EV 71.
• Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology.J Clin Virol.2014 Jan 7. pii: S1386-6532(13)00543-X. doi: 10.1016/j.jcv.2013.12.012. [Epub ahead of print]
• BACKGROUND: Hand foot and mouth disease (HFMD) is a common childhood manifestation of enterovirus (EV) infection. It predominantly affects young children, and has been mainly associated with coxsackievirus (CV) A16 and EV 71.OBJECTIVES: We report an unusual cluster of adult patients with HFMD.STUDY
• PMID 24457116

• Pathogenic Rickettsia species acquire vitronectin from human serum to promote resistance to complement-mediated killing.

• Riley SP, Patterson JL, Nava S, Martinez JJ.Author information Department of Microbiology, University of Chicago, Chicago, IL, 60637, USA; Howard T. Ricketts Laboratory, Argonne, IL, 60439, USA; Vector-Borne Diseases Laboratories, Department of Pathobiological Sciences, Louisiana State University School of Veterinary Medicine, Baton Rouge, LA, 70803, USA.AbstractBacteria of the genus Rickettsia are transmitted from arthropod vectors and primarily infect cells of the mammalian endothelial system. Throughout this infectious cycle, the bacteria are exposed to the deleterious effects of serum complement. Using Rickettsia conorii, the etiologic agent of Mediterranean spotted fever (MSF), as a model rickettsial species, we have previously demonstrated that this class of pathogen interacts with human factor H to mediate partial survival in human serum. Herein, we demonstrate that R. conorii also interacts with the terminal complement complex inhibitor vitronectin (Vn). We further demonstrate that an evolutionarily conserved rickettsial antigen, Adr1/RC1281, interacts with human vitronectin and is sufficient to mediate resistance to serum killing when expressed at the outer-membrane of serum sensitive Escherichia coli. Adr1 is an integral outer-membrane protein whose structure is predicted to contain eight membrane-embedded β-strands and four 'loop' regions that are exposed to extracellular milieu. Site-directed mutagenesis of Adr1 revealed that at least two predicted 'loop' regions are required to mediate resistance to complement-mediatedkilling and vitronectin acquisition. These results demonstrate that rickettsial species have evolved multiple mechanisms to evade complement deposition and that evasion of killing in serum is an evolutionarily conserved virulence attribute for this genus of obligate intracellular pathogens.
• Cellular microbiology.Cell Microbiol.2013 Nov 29. doi: 10.1111/cmi.12243. [Epub ahead of print]
• Bacteria of the genus Rickettsia are transmitted from arthropod vectors and primarily infect cells of the mammalian endothelial system. Throughout this infectious cycle, the bacteria are exposed to the deleterious effects of serum complement. Using Rickettsia conorii, the etiologic agent of Mediterr
• PMID 24286496

• Mediterranean Spotted Fever in Children in the Pazardjik Region, South Bulgaria.

• Pishmisheva M, Stoycheva M, Vatev N, Semerdjieva M.Author information 1Regional Hospital - Pazardzhik, Dept. Infectious Diseases 2Medical University - Plovdiv, Dept. Infectious Diseases, Parasitology and Tropical Medicine 3Medical University - Plovdiv, Dept. Epidemiology of Infectious Diseases 4Medical University - Plovdiv, Dept. Management of Public Health.AbstractThe objective of the present study was to analyze the clinical pattern of contemporary Mediterranean spotted fever in children and to compare it with the clinical pattern in adults. The research involved 257 children. The more common symptoms in children were severe onset, fever, rash, "tache noire", swelling of lymph nodes and enlarged liver or spleen.
• The Pediatric infectious disease journal.Pediatr Infect Dis J.2013 Nov 20. [Epub ahead of print]
• The objective of the present study was to analyze the clinical pattern of contemporary Mediterranean spotted fever in children and to compare it with the clinical pattern in adults. The research involved 257 children. The more common symptoms in children were severe onset, fever, rash, "tache noire"
• PMID 24263221

Japanese Journal

• Mediterranean spotted fever and encephalitis : a case report and review of the literature

• DUQUE Vitor,VENTURA Conceicao,SEIXAS Diana,BARAI Arnaldo,MENDONCA Nuno,MARTINS Joana,DA CUNHA Saraiva,MELICO-SILVESTRE Antonio
• Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 18(1), 105-108, 2012-02-01
• NAID 10030226573

• Mediterranean spotted fever : A review of fifteen cases

• MERT Ali,OZARAS Resat,TABAK Fehmi,BILIR Muammer,OZTURK Recep
• Journal of dermatology 33(2), 103-107, 2006-02-01
• NAID 10019171472

Related Links

• Boutonneuse Fever Treatment & Management: Approach ...

Boutonneuse fever (BF), also known as Mediterranean spotted fever (MSF), is transmitted by the dog tick Rhipicephalus sanguineus. The tick bite causes a characteristic rash and a distinct mark—namely, a tache noire ...

• Questions on Mediterranean Spotted Fever a Century after Its ...

Mediterranean spotted fever (MSF) was first described in 1910. Twenty years later, it was recognized as a rickettsial disease transmitted by the brown dog tick. In contrast to Rocky Mountain spotted fever (RMSF), MSF ...

Related Pictures

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★リンクテーブル★

リンク元	「Rickettsia conorii」「地中海紅斑熱」「地中海斑点熱」「Mediterranean紅斑熱」
関連記事	「spotted」「Mediterranean」

「Rickettsia conorii」

　　[★]

ラ

Rickettsia conorii

同

リケッチア・コノーリイ、リケッチア・コノリー

関

Mediterranean spotted fever

「地中海紅斑熱」

　　[★]

英

Mediterranean spotted fever

関

地中海斑点熱、ボタン熱、Mediterranean紅斑熱

「地中海斑点熱」

　　[★]

英

Mediterranean spotted fever

関

地中海紅斑熱、Mediterranean紅斑熱

「Mediterranean紅斑熱」

　　[★]

英

Mediterranean spotted fever

関

地中海紅斑熱、地中海斑点熱

「spotted」

　　[★]

• adj.

• 点状の

関

punctate

　

「Mediterranean」

　　[★]

• adj.

• 地中海の