WordNet
- landlocked republic on the Balkan Peninsula; achieved independence from Yugoslavia in 1991
- Scottish physiologist who directed the research by F. G. Banting and C. H. Best that led to the discovery of insulin (1876-1935) (同)John Macleod, John James Rickard Macleod
- a native of Sunderland
- the 13th letter of the Roman alphabet (同)m
PrepTutorEJDIC
- おい,君,名前の分からない相手（男）に対して呼びかけるときに使う, Apple社のMacintoshコンピューター
- (また『Macuedon』)マケドニア(古代ギリシア北方の地でアレキサンダー大王の生地)
- Mach number / mark[s] / Monsieur
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/27 01:18:41」(JST)
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- 1. HIV陰性患者における非結核性抗酸菌感染症の概要 overview of nontuberculous mycobacterial infections in hiv negative patients
- 2. HIV感染患者におけるMycobacterium avium complex (MAC）感染症 mycobacterium avium complex mac infections in hiv infected patients
- 3. HIV陰性患者における肺非結核性抗酸菌感染症の治療 treatment of nontuberculous mycobacterial infections of the lung in hiv negative patients
- 4. 非結核性抗酸菌感染症の疫学 epidemiology of nontuberculous mycobacterial infections
- 5. 小児における非結核性抗酸菌性肺感染症の概要 overview of nontuberculous mycobacterial pulmonary infections in children
English Journal
- Improving cardiovascular outcomes in rheumatic diseases: Therapeutic potential of circulating endothelial progenitor cells.
- Reynolds JA1, Robertson AC2, Bruce IN3, Alexander MY4.Author information 1Arthritis Research UK Epidemiology Unit, Institute of Inflammation and Repair, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, UK. Electronic address: John.reynolds@manchester.ac.2Institute of Cardiovascular Sciences, Manchester Academic Health Sciences Centre, The University of Manchester, UK.3Arthritis Research UK Epidemiology Unit, Institute of Inflammation and Repair, Manchester Academic Health Sciences Centre, The University of Manchester, Manchester, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, and Kellgren Centre for Rheumatology, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK.4Institute of Cardiovascular Sciences, Manchester Academic Health Sciences Centre, The University of Manchester, UK; Healthcare Science Research Institute, Manchester Metropolitan University, UK Healthcare Science Research Institute, Manchester Metropolitan University, UK.AbstractPatients with Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) have a significantly increased risk of cardiovascular disease (CVD). The reason for this is unclear but may be due, at least in part, to the failure of endothelial repair mechanisms. Over the last 15years there has been much interest in the mechanisms of endothelial renewal and its potential as a therapy for CVD. In the circulation there are two distinct populations of cells; myeloid angiogenic cells (MACs) which augment repair by the paracrine secretion of angiogenic factors, and outgrowth endothelial cells (OECs) which are true endothelial progenitor cells (EPCs) and promote vasculogenesis by differentiating into mature endothelium. There are marked abnormalities in the number and function of these cells in patients with RA and SLE. Inflammatory cytokines including interferon-alpha (IFNα) and tumour-necrosis factor alpha (TNFα) both impair MAC and OEC function ex vivo and may therefore contribute to the CVD risk in these patients. Whilst administration of mononuclear cells, MACs and other progenitors has improved cardiovascular outcomes in the acute setting, this is not a viable option in chronic disease. The pharmacological manipulation of MAC/OEC function in vivo however has the potential to significantly improve endothelial repair and thus reduce CVD in this high risk population.
- Pharmacology & therapeutics.Pharmacol Ther.2014 May;142(2):231-243. doi: 10.1016/j.pharmthera.2013.12.008. Epub 2013 Dec 12.
- Patients with Rheumatoid Arthritis (RA) and Systemic Lupus Erythematosus (SLE) have a significantly increased risk of cardiovascular disease (CVD). The reason for this is unclear but may be due, at least in part, to the failure of endothelial repair mechanisms. Over the last 15years there has been m
- PMID 24333265
- Hydroxyapatite and calcified elastin induce osteoblast-like differentiation in rat aortic smooth muscle cells.
- Lei Y1, Sinha A1, Nosoudi N1, Grover A1, Vyavahare N2.Author information 1Department of Bioengineering, Clemson University, USA.2Department of Bioengineering, Clemson University, USA. Electronic address: narenv@clemson.edu.AbstractVascular calcification can be categorized into two different types. Intimal calcification related to atherosclerosis and elastin-specific medial arterial calcification (MAC). Osteoblast-like differentiation of vascular smooth muscle cells (VSMCs) has been shown in both types; however, how this relates to initiation of vascular calcification is unclear. We hypothesize that the initial deposition of hydroxyapatite-like mineral in MAC occurs on degraded elastin first and that causes osteogenic transformation of VSMCs. To test this, rat aortic smooth muscle cells (RASMCs) were cultured on hydroxyapatite crystals and calcified aortic elastin. Using RT-PCR and specific protein assays, we demonstrate that RASMCs lose their smooth muscle lineage markers like alpha smooth muscle actin (SMA) and myosin heavy chain (MHC) and undergo chondrogenic/osteogenic transformation. This is indicated by an increase in the expression of typical chondrogenic proteins such as aggrecan, collagen type II alpha 1(Col2a1) and bone proteins such as runt-related transcription factor 2 (RUNX2), alkaline phosphatase (ALP) and osteocalcin (OCN). Furthermore, when calcified conditions are removed, cells return to their original phenotype. Our data supports the hypothesis that elastin degradation and calcification precedes VSMCs' osteoblast-like differentiation.
- Experimental cell research.Exp Cell Res.2014 Apr 15;323(1):198-208. doi: 10.1016/j.yexcr.2014.01.011. Epub 2014 Jan 18.
- Vascular calcification can be categorized into two different types. Intimal calcification related to atherosclerosis and elastin-specific medial arterial calcification (MAC). Osteoblast-like differentiation of vascular smooth muscle cells (VSMCs) has been shown in both types; however, how this relat
- PMID 24447384
- Preparation and pharmaceutical evaluation of nano-fiber matrix supported drug delivery system using the solvent-based electrospinning method.
- Hamori M1, Yoshimatsu S1, Hukuchi Y1, Shimizu Y1, Fukushima K2, Sugioka N2, Nishimura A1, Shibata N3.Author information 1Department of Bioharmaceutics, Faculty of Pharmaceutical Science, Doshisha Women's College of Liberal Arts, Kyotanabe, Kyoto 610-0395, Japan.2Department of Clinical Pharmacokinetics, Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Hyogo 650-8586, Japan.3Department of Bioharmaceutics, Faculty of Pharmaceutical Science, Doshisha Women's College of Liberal Arts, Kyotanabe, Kyoto 610-0395, Japan. Electronic address: nshibata@dwc.doshisha.ac.jp.AbstractIn this study, utilizing the solvent-based electrospinning (ES) method, which is mainly employed in the textile industry, we prepared nanofiber-based capsules including drugs for controlled-release delivery systems using methacrylic acid copolymer (EUDRAGIT(®) S100, MAC) as a polymer, and evaluated their in vitro drug dissolution profiles and in vivo pharmacokinetics in rats. As the model drugs, uranine (UN) was used as a water-soluble drug and nifedipine (NP) as a water-insoluble drug. The mean diameters of drug free nano-fiber and nano-fiber including NP or UN were 751.5±67.2, 703.3±71.2 and 2477.8±206.1nm, respectively. X-ray diffraction for the nano-fibrotic sheet showed that UN and/or NP were packed in nano-fiber in an amorphous form. The in vitro release of UN or NP from the nano-fiber packed capsules (NFPC) and milled-powder of nano-fiber packed capsules (MPPC) showed controlled release of UN or NP as compared to capsules of a physical mixture of MAC and each drug. An in vivo pharmacokinetic study in rats after intraduodenal administration of NFPC or MPPC including UN and/or NP clearly demonstrated that application of nano-fibrotic technique as a drug delivery system offers drastic changes in pharmacokinetic profiles for both water-soluble and water-insoluble drugs. The ES method is a useful technique to prepare a nano-fiber like solid dispersion for polar or nonpolar drugs, and has wide potential pharmaceutical applications.
- International journal of pharmaceutics.Int J Pharm.2014 Apr 10;464(1-2):243-51. doi: 10.1016/j.ijpharm.2013.12.036. Epub 2014 Jan 16.
- In this study, utilizing the solvent-based electrospinning (ES) method, which is mainly employed in the textile industry, we prepared nanofiber-based capsules including drugs for controlled-release delivery systems using methacrylic acid copolymer (EUDRAGIT(®) S100, MAC) as a polymer, and evaluated
- PMID 24440839
Japanese Journal
- フリー・ソフト活用 Windows/Mac/Linux対応でI/Oもサクッ! オープンソースのブロック型言語Pure Dataではじめるサウンド信号処理(第2回)サウンド処理の基本満載!レガシ・ピコピコ音BGM
- インターフェース = Interface 42(1), 170-173, 2016-01
- NAID 40020659195
- フリー・ソフト活用 Windows/Mac/Linux対応でI/Oもサクッ! オープンソースのブロック型言語Pure Dataではじめるサウンド信号処理(第1回)正弦波/ノコギリ波/矩形波…まずは基本音を鳴らす
- インターフェース = Interface 41(12), 162-165, 2015-12
- NAID 40020627760
- 症例 抗菌薬治療にて改善した非結核性抗酸菌症合併自己免疫性肺胞蛋白症の1例
- 日本呼吸器学会誌 = Annals of the Japanese Respiratory Society 4(6), 478-482, 2015-11-10
- NAID 40020654248
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- Macの世界へようこそ。新しいMacBook、iMac、Mac Proなどを紹介します。あなたのMacを最大限に活用するためのパワフルなアプリケーションも見つかります。 ... Apple Online Store Macをあなたの使い方に合わせて カスタマイズできます。 ...
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Related Pictures
★リンクテーブル★
| リンク元 | 「マッキントッシュ」「マック」「Macintosh」 |
| 拡張検索 | 「Macaca nemestrina」「Exomphalos, Macroglossia, Gigantism症候群」「Macropus属」「Macaca属」「Strickland and Mackay classification」 |
| 関連記事 | 「MAC」「M」 |
「マッキントッシュ」
「マック」
「Macintosh」
- 関
- Mac
「Macaca nemestrina」
- 関
- pig-tailed macaque、pig-tailed monkey、pigtail macaque、pigtailed macaque、pigtailed monkey
「Exomphalos, Macroglossia, Gigantism症候群」
- 英
- Exomphalos-Macroglossia-Gigantism syndrome
- 同
- Beckwith-Wiedemann症候群, EMG
「Macropus属」
「Macaca属」
「Strickland and Mackay classification」
「MAC」
- 僧帽弁輪石灰化 mitral annular calcification
- 最小肺胞内濃度 minimum alveolar concentration
- 膜攻撃複合体 membrane attack complex
- Mycobacterium avium complex
- 監視下鎮静管理 monitored anesthesia care
- 哺乳類人工染色体 mammalian artificial chromosome