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1. 黒色腫（メラノーマ）の分子生物学 the molecular biology of melanoma
2. 進行皮膚黒色腫に対するマネージメントの概要 overview of the management of advanced cutaneous melanoma
3. 転移性黒色腫（メラノーマ）の分子標的療法 molecularly targeted therapy for metastatic melanoma
4. 関節リウマチの病因 pathogenesis of rheumatoid arthritis
5. 心臓の虚血性再潅流障害 ischemic reperfusion injury of the heart

Low concentrations of trichosanthin induce apoptosis and cell cycle arrest via c‑Jun N‑terminal protein kinase/mitogen‑activated protein kinase activation.

Zhang D1, Chen B1, Zhou J1, Zhou L2, Li Q2, Liu F2, Chou KY2, Tao L1, Lu LM2.
Molecular medicine reports.Mol Med Rep.2015 Jan;11(1):349-56. doi: 10.3892/mmr.2014.2760. Epub 2014 Oct 23.
Trichosanthin (TCS) is a type I ribosome‑-inactivating protein, which inhibits cell viability in human epithelial type 2 (HEp‑2) and AMC‑HN‑8 human laryngeal epidermoid carcinoma cells. Although TCS is a potential chemotherapeutic agent, its mechanism of action remains to be elucidated. In
PMID 25351837

Melatonin alleviates myosin light chain kinase expression and activity via the mitogen‑activated protein kinase pathway during atherosclerosis in rabbits.

Cheng X1, Wan Y2, Xu Y3, Zhou Q1, Wang Y1, Zhu H1.
Molecular medicine reports.Mol Med Rep.2015 Jan;11(1):99-104. doi: 10.3892/mmr.2014.2753. Epub 2014 Oct 23.
Melatonin (MLT) is an endogenous indole compound with numerous biological activities that has been associated with atherosclerosis (AS). In the present study, rabbits were used as an AS model in order to investigate whether MLT affects endothelial cell permeability, myosin light chain kinase (MLCK)
PMID 25339116

Poenitzsch Strong AM1, Setaluri V2, Spiegelman VS3.
Archives of biochemistry and biophysics.Arch Biochem Biophys.2014 Dec 1;563:118-24. doi: 10.1016/j.abb.2014.07.012. Epub 2014 Jul 17.
microRNA (miRNA)-dependent regulation of gene expression is increasingly linked to development and progression of melanoma. In this study we evaluated the functions of miR-340 in human melanoma cells. Here, we show that miR-340 inhibits the tumorigenic phenotype of melanoma cells. We also found that
PMID 25043973