関: microtubule-associated protein 2

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/04/13 03:09:52」(JST)

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Microtubule-associated protein 2 is a protein that in humans is encoded by the MAP2 gene.^[5]^[6]

Function

This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neuritogenesis. MAP2 serves to stabilize microtubules (MT) growth by crosslinking MT with intermediate filaments and other MTs. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dendrites, implicating a role in determining and stabilizing dendritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described.^[7]

Interactions

MAP2 has been shown to interact with Grb2,^[8]^[9] NEFL^[10] and MYO7A.^[11] MAP2 is suspected of interacting with tubulin.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000078018 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000015222 - Ensembl, May 2017
^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ Neve RL, Harris P, Kosik KS, Kurnit DM, Donlon TA (May 1987). "Identification of cDNA clones for the human microtubule-associated protein tau and chromosomal localization of the genes for tau and microtubule-associated protein 2". Brain Res. 387 (3): 271–80. PMID 3103857.
^ Kalcheva N, Albala J, O'Guin K, Rubino H, Garner C, Shafit-Zagardo B (December 1995). "Genomic structure of human microtubule-associated protein 2 (MAP-2) and characterization of additional MAP-2 isoforms". Proc Natl Acad Sci U S A. 92 (24): 10894–8. doi:10.1073/pnas.92.24.10894. PMC 40537 . PMID 7479905.
^ "Entrez Gene: MAP2 microtubule-associated protein 2".
^ Lim RW, Halpain S (July 2000). "Regulated association of microtubule-associated protein 2 (MAP2) with Src and Grb2: evidence for MAP2 as a scaffolding protein". J. Biol. Chem. 275 (27): 20578–87. doi:10.1074/jbc.M001887200. PMID 10781592.
^ Zamora-Leon SP, Lee G, Davies P, Shafit-Zagardo B (October 2001). "Binding of Fyn to MAP-2c through an SH3 binding domain. Regulation of the interaction by ERK2". J. Biol. Chem. 276 (43): 39950–8. doi:10.1074/jbc.M107807200. PMID 11546790.
^ Frappier T, Stetzkowski-Marden F, Pradel LA (April 1991). "Interaction domains of neurofilament light chain and brain spectrin". Biochem. J. 275 (Pt 2): 521–7. doi:10.1042/bj2750521. PMC 1150082 . PMID 1902666.
^ Todorov PT, Hardisty RE, Brown SD (March 2001). "Myosin VIIA is specifically associated with calmodulin and microtubule-associated protein-2B (MAP-2B)". Biochem. J. 354 (Pt 2): 267–74. doi:10.1042/0264-6021:3540267. PMC 1221652 . PMID 11171103.

UpToDate Contents

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1. レット症候群 rett syndrome

English Journal

The effect of substrate topography on direct reprogramming of fibroblasts to induced neurons.

Kulangara K1, Adler AF1, Wang H2, Chellappan M1, Hammett E1, Yasuda R3, Leong KW4.
Biomaterials.Biomaterials.2014 Jul;35(20):5327-36. doi: 10.1016/j.biomaterials.2014.03.034. Epub 2014 Apr 4.
Cellular reprogramming holds tremendous potential for cell therapy and regenerative medicine. Recently, fibroblasts have been directly converted into induced neurons (iNs) by overexpression of the neuronal transcription factors Ascl1, Brn2 and Myt1L. Hypothesizing that cell-topography interactions c
PMID 24709523

Neurogenin 2 Enhances the Neuronal Differentiation of Skin-derived Precursors.

Dai X1, Lu X, Cheng F, Hao H, Qian T, Yu W, Tang L, Li L.
The International journal of neuroscience.Int J Neurosci.2014 Jun 19:1-24. [Epub ahead of print]
Abstracts Skin-derived precursors (SKPs), a novel stem cell population isolated from mammalian skin, can differentiate into neural and mesodermal lineages. Cell therapy using SKPs seems like a promising approach for the treatment of neural diseases, however, the low efficiency of neuronal differenti
PMID 24946204

The Synergistic Effect of Nanotopography and Sustained Dual Release of Hydrophobic and Hydrophilic Neurotrophic Factors on Human Mesenchymal Stem Cell Neuronal Lineage Commitment.

Teo BK1, Tan GD, Yim EK.
Tissue engineering. Part A.Tissue Eng Part A.2014 Jun 16. [Epub ahead of print]
A combination of nanotopography and controlled release is a potential platform for neuronal tissue engineering applications. Previous studies showed that combining both physical and chemical guidance was more effective than individual cues in the directional promotion of neurite outgrowth. Nanotopog
PMID 24932660

Japanese Journal

Functional expression of carnitine/organic cation transporter OCTN1 in mouse brain neurons: Possible involvement in neuronal differentiation

Nakamichi Noritaka,Taguchi Takayuki,Hosotani Hiroshi,Wakayama Tomohiko,Shimizu Takuya,Sugiura Tomoko,Iseki Shoichi,Kato Yukio
Neurochemistry International 61(7), 1211-1132, 2012-12-00
… Immunohistochemical analysis revealed colocalization of OCTN1 with neuronal cell markers microtubule-associated protein 2 (MAP2) and βIII-tubulin in mouse brain and primary cultured cortical neurons, respectively. …
NAID 120004966621

Rice Mitogen-Activated Protein Kinase Interactome Analysis Using the Yeast Two-Hybrid System

Singh Raksha,Lee Mi-Ok,Lee Jae-Eun,Choi Jihyun,Park Ji Hun,Kim Eun Hye,Yoo Ran Hee,Cho Jung-Il,Jeon Jong-Seong,Rakwal Randeep,Agrawal Ganesh Kumar,Moon Jae Sun
Plant physiology 160(1), 477-487, 2012-09-00
… The established interactome contains four membrane-associated proteins, seven MAP2Ks (for MAPK kinase), four MAPKs, and 59 putative substrates, including 18 transcription factors. …
NAID 120004754591

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★リンクテーブル★

リンク元	「微小管結合タンパク質2」「microtubule-associated protein 2」
関連記事	「MAP」「MA」

「微小管結合タンパク質2」

MAP2
Identifiers
Aliases	MAP2, MAP2A, MAP2B, MAP2C, microtubule associated protein 2
External IDs	MGI: 97175 HomoloGene: 1779 GeneCards: MAP2
Gene location (Human)
Chr.	Chromosome 2 (human)
End	209,734,118 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	66,442,583 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• tubulin binding; • protein binding; • structural molecule activity; • dystroglycan binding; • calmodulin binding; • microtubule binding;
Cellular component	• nucleolus; • microtubule; • microtubule associated complex; • cytoskeleton; • cytoplasm; • cytosol; • dendrite; • cell projection; • intracellular; • postsynaptic density; • nuclear periphery; • neuron projection; • neuronal cell body; • dendritic shaft; • cell body; • CA3 pyramidal cell dendrite;
Biological process	• neuron projection development; • microtubule cytoskeleton organization; • microtubule bundle formation; • dendrite morphogenesis; • central nervous system neuron development; • axonogenesis; • dendrite development; • establishment of cell polarity; • regulation of axonogenesis; • cellular response to organic substance;
	Sources:Amigo / QuickGO
Orthologs
	4133
	17756
	ENSG00000078018
	ENSMUSG00000015222
	P11137
	P20357
	NM_001039538; NM_002374; NM_031845; NM_031846; NM_031847
	NM_001039934; NM_008632; NM_001310634
	NP_001034627; NP_002365; NP_114033; NP_114035
	NP_001035023; NP_001297563; NP_032658
	Wikidata
View/Edit Human	View/Edit Mouse