関: Leptospira

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/30 02:59:49」(JST)

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Leptospiraceae is a family of spirochetes.^[1]

It includes the genus Leptospira.^[2]

References

^ "www.ncbi.nlm.nih.gov". http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Tree&id=170&lvl=3&lin=f&keep=1&srchmode=1&unlock. Retrieved 2009-04-22.
^ Morey RE, Galloway RL, Bragg SL, Steigerwalt AG, Mayer LW, Levett PN (October 2006). "Species-specific identification of Leptospiraceae by 16S rRNA gene sequencing". J. Clin. Microbiol. 44 (10): 3510–6. doi:10.1128/JCM.00670-06. PMC 1594759. PMID 17021075. http://jcm.asm.org/cgi/pmidlookup?view=long&pmid=17021075.

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English Journal

The serological response of working farm dogs to a vaccine containing Leptospira interrogans serovars Copenhageni and Pomona, and L. borgpetersenii serovar Hardjo.

Cave NJ1, Harland AL, Allott SK.Author information 1a Institute of Veterinary , Animal, and Biomedical Sciences, Massey University , Private Bag 11-222, Palmerston North 4442 , New Zealand.AbstractAIMS: To evaluate the serological response in dogs to a commercial vaccine for use in cattle containing cultured strains of Leptospira interrogans serovars Copenhageni and Pomona, and L. borgpetersenii serovar Hardjo.
New Zealand veterinary journal.N Z Vet J.2014 Mar;62(2):87-90. doi: 10.1080/00480169.2013.845072. Epub 2013 Nov 15.
AIMS: To evaluate the serological response in dogs to a commercial vaccine for use in cattle containing cultured strains of Leptospira interrogans serovars Copenhageni and Pomona, and L. borgpetersenii serovar Hardjo.METHODS: Blood samples were obtained from 67 working farm dogs on 12 farms, and the
PMID 24228620

Seroprevalence of Leptospira hardjo in cattle and African buffalos in southwestern Uganda.

Atherstone C1, Picozzi K, Kalema-Zikusoka G.Author information 1College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom; MSc Student International Animal Health Programme, Division of Pathway Medicine and Centre for Infectious Diseases, School of Biomedical Sciences, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom; Conservation through Public Health, Entebbe, Uganda.AbstractLeptospirosis, caused by the spirochete bacterium Leptospira spp. is a zoonosis, distributed worldwide and classified as an emerging infectious disease. Fatal outcomes to leptospiral infection do occur and the disease can cause abortion and other reproductive problems in cattle, goats, and pigs. In humans the symptoms range from subclinical infection to acute febrile illness, pulmonary hemorrhage and renal failure. Leptospirosis has never been officially reported to the World Health Organization (WHO) or the World Animal Health Organization in animals or humans in Uganda. However, favorable ecological conditions and suitable animal hosts can be found within the country. A commercially available enzyme-linked immunosorbent (ELISA) kit was used to screen sera samples from domesticated cattle and African buffalo (Syncerus caffer) at two locations in southwestern Uganda, collected over a 4-year period. Positive samples were found in both cattle and African buffalo samples, from both locations and across the sampling period. Overall seroprevalence was 42.39% in African buffalo and 29.35% in cattle.
The American journal of tropical medicine and hygiene.Am J Trop Med Hyg.2014 Feb;90(2):288-90. doi: 10.4269/ajtmh.13-0466. Epub 2013 Dec 9.
Leptospirosis, caused by the spirochete bacterium Leptospira spp. is a zoonosis, distributed worldwide and classified as an emerging infectious disease. Fatal outcomes to leptospiral infection do occur and the disease can cause abortion and other reproductive problems in cattle, goats, and pigs. In
PMID 24323512

Oral immunization with Escherichia coli expressing a lipidated form of LigA protects hamsters against challenge with Leptospira interrogans serovar Copenhageni.

Lourdault K1, Wang LC, Vieira A, Matsunaga J, Melo R, Lewis MS, Haake DA, Gomes-Solecki M.Author information 1VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.AbstractLeptospirosis is a potentially fatal zoonosis transmitted by reservoir host animals that harbor leptospires in their renal tubules and shed the bacteria in their urine. Leptospira interrogans serovar Copenhageni transmitted from Rattus norvegicus to humans is the most prevalent cause of urban leptospirosis. We examined L. interrogans LigA, domains 7 to 13 (LigA7-13), as an oral vaccine delivered by Escherichia coli as a lipidated, membrane-associated protein. The efficacy of the vaccine was evaluated in a susceptible hamster model in terms of the humoral immune response and survival from leptospiral challenge. Four weeks of oral administration of live E. coli expressing LigA7-13 improved survival from intraperitoneal (i.p.) and intradermal (i.d.) challenge by L. interrogans serovar Copenhageni strain Fiocruz L1-130 in Golden Syrian hamsters. Immunization with E. coli expressing LigA7-13 resulted in a systemic antibody response, and a significant LigA7-13 IgG level after the first 2 weeks of immunization was completely predictive of survival 28 days after challenge. As in previous LigA vaccine studies, all immunized hamsters that survived infection had renal leptospiral colonization and histopathological changes. In summary, an oral LigA-based vaccine improved survival from leptospiral challenge by either the i.p. or i.d. route.
Infection and immunity.Infect Immun.2014 Feb;82(2):893-902. doi: 10.1128/IAI.01533-13. Epub 2013 Dec 9.
Leptospirosis is a potentially fatal zoonosis transmitted by reservoir host animals that harbor leptospires in their renal tubules and shed the bacteria in their urine. Leptospira interrogans serovar Copenhageni transmitted from Rattus norvegicus to humans is the most prevalent cause of urban leptos
PMID 24478102

Japanese Journal

ENZYME ACTIVITIES OF THE STRAINS BELONGING TO FAMILY LEPTOSPIRACEAE DETECTED BY THE API ZYM SYSTEM, AND SELECTION OF ANTIGENIC VARIANTS FROM LEPTOSPIRA INTERROGANS SEROVAR CANICOLA BY MEANS OF ANTI-CANICOLA MONOCLONAL ANTIBODY