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1. 膵β細胞の機能pancreatic beta cell function [show details]
… Pancreatic beta cells are found in the islets of Langerhans, which are of various size and contain a few hundred to a few thousand endocrine cells. Islets are anatomically and functionally separate …
2. 糖尿病における膵臓および膵島移植pancreas and islet transplantation in diabetes mellitus [show details]
… diabetes, patients with chronic pancreatitis undergo islet transplantation in conjunction with total pancreatectomy, with infusion of their own islets (auto-islet transplantation), which does not require treatment …
3. 非インスリノーマ低血糖症候群noninsulinoma pancreatogenous hypoglycemia syndrome [show details]
… are characteristic of nesidioblastosis, a term that refers to neoformation of islets of Langerhans from pancreatic duct epithelium . The pathologic findings are similar to those seen in neonates and infants …
4. 糖尿病患者への膵腎移植：移植時の注意点および免疫抑制療法pancreas kidney transplantation in diabetes mellitus surgical considerations and immunosuppression [show details]
…evaluation, and the diagnosis and treatment of rejection are discussed elsewhere. The roles of PTA and islet transplantation in diabetic patients without renal failure are discussed separately. In the United…
5. 糖尿病でない成人における低血糖症：診断的アプローチhypoglycemia in adults without diabetes mellitus diagnostic approach [show details]
…is endogenous hyperinsulinemia due to islet hypertrophy and nesidioblastosis, a form of primary islet cell hypertrophy with neodifferentiation of islet of Langerhans cells from pancreatic duct epithelium …

English Journal

Redefining the signaling pathways from pluripotency to pancreas development: In vitro β-cell differentiation.

Hashemitabar M, Heidari E.
Journal of cellular physiology. 2019 Jun;234(6)7811-7827.
Pancreatic β-cells are destroyed by the immune system, in type 1 diabetes (T1D) and are impaired by glucose insensitivity in type 2 diabetes (T2D). Islet-cells transplantation is a promising therapeutic approach based on in vitro differentiation of pluripotent stem cells (PSCs) to insulin-producing
PMID 30480819

Temporal analysis of distribution pattern of islet cells and antioxidant enzymes for diabetes onset in postnatal critical development window in rats.

Gallego FQ, Miranda CA, Sinzato YK, Iessi IL, Dallaqua B, Pando RH, Rocha NS, Volpato GT, Damasceno DC.
Life sciences. 2019 Jun;226()57-67.
At performing a temporal analysis of the distribution pattern of islet endocrine cells and antioxidant enzymes in diabetic rats during the post-natal critical development window. The newborns received streptozotocin (STZ) at birth for diabetes induction, and control females received the vehicle. The
PMID 30930115

Modulatory effect of empagliflozin on cellular parameters of endocrine pancreas in experimental pre-diabetes.

Abdel-Hamid AAM, Firgany AEL.
Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft. 2019 May;().
The effect of empagliflozin (EMPA), a sodium-glucose cotransporter 2 inhibitor (SGLT2i), on the structure of endocrine pancreas in pre-diabetes (Pre-DM) is not yet elucidated. In the current study the relatively enlarged islets of Langerhans seen in the Pre-DM group was restored to control size by a
PMID 31108190

Japanese Journal

親水環境での電子顕微鏡：クライオ電顕とASEM組織観察

佐藤主税,Memtily Nassirhadjy,佐藤真理,杉本真也
表面と真空 62(4), 198-204, 2019
… the islet of Langerhans in pancreas and blood cells in the capillaries, and further to cancer metastases.</p> …
NAID 130007630430

Development of monoclonal mouse antibodies that specifically recognize pancreatic polypeptide

Hara Akemi,Watada Hirotaka,Fujitani Yoshio,Nakagawa Yuko,Nakao Keiko,Tamaki Motoyuki,Ikemoto Tetsuya,Shimada Mitsuo,Matsuhisa Munehide,Mizukami Hiroki,Maruyama Nobuhiro
Endocrine Journal, 2019
… gene, which is produced by a small population of cells located in the periphery of the islets of Langerhans. …
NAID 130007607895

Therapeutic Effect of an Immunomodulator on Pancreatic Endocrine Secretion Disorder and Insulitis in an Animal Model of Autoimmune Pancreatitis

MITSUI Yuta,IMAMURA Tsunao,IKEGAMI Akitoshi,TANAKA Shigeki,YOSHIDA Hitoshi,HONMA Tadashi,SATO Yoshiki,YAMAMIYA Akira,ISHII Yu,NOMOTO Tomohiro,YAMAZAKI Takahisa,YUKAWA Akihiro,KITAMURA Katsuya
Ｔｈｅ　Ｓｈｏｗａ　Ｕｎｉｖｅｒｓｉｔｙ　Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃａｌ　Ｓｃｉｅｎｃｅｓ 30(2), 197-210, 2018
… In the pancreatitis group, insulitis resulted in morphological changes such as shrinkage of pancreatic islets of Langerhans as inflammatory cell infiltration into pancreatic acinar cells became stronger. … No significant difference was observed between the 1mg group and the pancreatitis group in the islet area but, in the 2mg group, there was significant reduction in area compared to the pancreatitis group and the 1mg group. …
NAID 130007472787