左室肥大 LVH
WordNet
- abnormal enlargement of a body part or organ
- undergo hypertrophy; "muscles can hypertrophy when people take steroids"
- the 12th letter of the Roman alphabet (同)l
PrepTutorEJDIC
- (生物体の部分・器官の)異常肥大,異常発達
- lira(イタリアの貨幣単位リラ)
UpToDate Contents
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- 1. 左室肥大の心電図による診断 electrocardiographic diagnosis of left ventricular hypertrophy
- 2. 高血圧における左室肥大の臨床的意義および治療 clinical implications and treatment of left ventricular hypertrophy in hypertension
- 3. 高血圧における左室肥大の定義および病因 definition and pathogenesis of left ventricular hypertrophy in hypertension
- 4. 左室肥大および不整脈 left ventricular hypertrophy and arrhythmia
- 5. 肥大型心筋症の臨床症状、診断、および評価 clinical manifestations diagnosis and evaluation of hypertrophic cardiomyopathy
English Journal
- PKCε promotes cardiac mitochondrial and metabolic adaptation to chronic hypobaric hypoxia by GSK3β inhibition.
- McCarthy J, Lochner A, Opie LH, Sack MN, Essop MF.SourceHatter Institute for Cardiovascular Research, University of Cape Town Medical School, Cape Town, South Africa. joy.mccarthy@uct.ac.za.
- Journal of cellular physiology.J Cell Physiol.2011 Sep;226(9):2457-68. doi: 10.1002/jcp.22592.
- PKCε is central to cardioprotection. Sub-proteome analysis demonstrated co-localization of activated cardiac PKCε (aPKCε) with metabolic, mitochondrial, and cardioprotective modulators like hypoxia-inducible factor 1α (HIF-1α). aPKCε relocates to the mitochondrion, inactivating glycogen syntha
- PMID 21660969
- Long-term in vivo resistin overexpression induces myocardial dysfunction and remodeling in rats.
- Chemaly ER, Hadri L, Zhang S, Kim M, Kohlbrenner E, Sheng J, Liang L, Chen J, K-Raman P, Hajjar RJ, Lebeche D.AbstractWe have previously reported that resistin induces hypertrophy and impairs contractility in isolated rat cardiomyocytes. To examine the long-term cardiovascular effects of resistin, we induced in vivo overexpression of resistin using adeno-associated virus serotype 9 injected by tail vein in rats and compared to control animals. Ten weeks after viral injection, overexpression of resistin was associated with increased ratio of left ventricular (LV) weight/body weight, increased end-systolic LV volume and significant decrease in LV contractility, measured by the end-systolic pressure volume relationship slope in LV pressure volume loops, compared to controls. At the molecular level, mRNA expression of ANF and β-MHC, and protein levels of phospholamban were increased in the resistin group without a change in the level of SERCA2a protein expression. Increased fibrosis by histology, associated with increased mRNA levels of collagen, fibronectin and connective tissue growth factor were observed in the resistin-overexpressing hearts. Resistin overexpression was also associated with increased apoptosis in vivo, along with an apoptotic molecular phenotype in vivo and in vitro. Resistin-overexpressing LV tissue had higher levels of TNF-α receptor 1 and iNOS, and reduced levels of eNOS. Cardiomyocytes overexpressing resistin in vitro produced larger amounts of TNFα in the medium, had increased phosphorylation of IκBα and displayed increased intracellular reactive oxygen species (ROS) content with increased expression and activity of ROS-producing NADPH oxidases compared to controls. Long-term resistin overexpression is associated with a complex phenotype of oxidative stress, inflammation, fibrosis, apoptosis and myocardial remodeling and dysfunction in rats. This phenotype recapitulates key features of diabetic cardiomyopathy. This article is part of Special Issue Item Group entitled "Possible Editorial".
- Journal of molecular and cellular cardiology.J Mol Cell Cardiol.2011 Aug;51(2):144-55. Epub 2011 Apr 23.
- We have previously reported that resistin induces hypertrophy and impairs contractility in isolated rat cardiomyocytes. To examine the long-term cardiovascular effects of resistin, we induced in vivo overexpression of resistin using adeno-associated virus serotype 9 injected by tail vein in rats and
- PMID 21549710
Japanese Journal
- Ischemic Preconditioning Effect of Prodromal Angina Is Attenuated in Acute Myocardial Infarction Patients With Hypertensive Left Ventricular Hypertrophy
- Takeuchi Toshiharu,Ishii Yoshinao,Kikuchi Kenjiro,Hasebe Naoyuki
- Circulation Journal 75(5), 1192-1199, 2011
- … Left ventricular (LV) function and LV mass index (LVMI) were measured by left ventriculography and echocardiography, respectively. … In patients without hypertension, prodromal angina resulted in significantly less myocardial damage on TL-SPECT, better LV ejection fraction and a greater myocardial blush grade compared to patients without prodromal angina. …
- NAID 130000657674
- Impact of Gestational Hypertension on Left Ventricular Function and Geometric Pattern
- Cho Kyoung-Im,Kim Seong-Man,Shin Mi-Seung,Kim Eui-Joo,Cho Eun-Joo,Seo Hae-Sun,Shin Sung-Hee,Yoon Se-Jung,Choi Jung-Hyun
- Circulation Journal 75(5), 1170-1176, 2011
- … Background: The effect of gestational hypertension on left ventricular (LV) function in previously normotensive young women has not been evaluated. … Transthoracic echocardiography, including 2-dimensional strain echocardiography, was done and myocardial performance (Tei index), LV mass index (LVMI), and relative wall thickness (RWT) were analyzed. …
- NAID 130000657671
Related Links
- In the 1960’s, the association of electrocardiographic LV hypertrophy with cardiovascular events was first described in clinical and population-based studies [3-5]. In the first study to relate direct measurements of ...
- There are massively increased QRS voltages — the S waves in V3 are so deep they are literally falling off the page! The ST elevation in V1-3 is simply in proportion to the very deep S waves (“appropriate discordance”). The LV strain ...
★リンクテーブル★
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- 英
- left ventricular hypertrophy, LV hypertrophy, LVH
- 関
- 心室肥大
概念
心電図
心電図 (心電図の読み方パーフェクトマニュアル p.115)
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- ST下降、Tの陰転化(ストレイン型。上に凸のST低下)
Sokolow&Lyon心電図上の診断基準
日本人に用いる場合
心電図の例
- 097D017
- [show details]
failpicload@./t_image/097D010.jpg
- 左室高電位とV5,V6でのST低下が認められるが、VATの延長は微妙。ぎりぎり0.04sか。
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左室肥大 left ventricular hypertrophy LV hypertrophy
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