WordNet
- the 12th letter of the Roman alphabet (同)l
- an amino acid containing sulfur that is found in most proteins; oxidizes on exposure to air to form cystine
- a complex consisting of an organic base in association with hydrogen chloride
PrepTutorEJDIC
- lira(イタリアの貨幣単位リラ)
- liter[s]
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- 1. ヘキソースリン酸側路およびグルタチオン代謝関連疾患 related disorders of the hexose monophosphate shunt and glutathione metabolism
- 2. 早産児における非経口栄養 parenteral nutrition in premature infants
- 3. 慢性閉塞性肺疾患（COPD）治療における粘膜作用剤の役割 role of mucoactive agents in the treatment of copd
- 4. 慢性閉塞性肺疾患（COPD）：危険因子およびリスク低減 chronic obstructive pulmonary disease risk factors and risk reduction
- 5. 小児における運動減少性運動障害 bradykinetic movement disorders in children
English Journal
- Ultraviolet A regulates the stemness of human adipose tissue-derived mesenchymal stem cells through downregulation of the HIF-1α via activation of PGE(2)-cAMP signaling.
- Lee J, Jung E, Hyun JW, Park D.Author information Department of Dermatological Health Management, Eul-Ji University, Seongnam City, 461-713 Gyunggi Do, Republic of Korea.AbstractUltraviolet A (UVA) irradiation is responsible for a variety of changes in cell biology. The purpose of this study was to investigate the effects of UVA irradiation on the stemness properties of human adipose tissue-derived mesenchymal stem cells (hAMSCs). Furthermore, we examined the UVA-antagonizing effects of L-cysteine ethylester hydrochloride (ethylcysteine) and elucidated its action mechanisms. The results of this study showed that UVA reduced the proliferative potential and stemness of hAMSCs, as evidenced by reduced proliferative activity in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and downregulation of OCT4, NANOG, and SOX2, stemness-related genes. The mRNA level of hypoxia-inducible factor (HIF)-1α, but not HIF-2α was reduced by UVA. Moreover, the knockdown of HIF-1α using small interfering RNA (siRNA) for HIF-1α was found to downregulate stemness genes, suggesting that UVA reduces the stemness through downregulation of HIF-1α. In addition, we examined the mechanisms underlying the UVA-mediated effects and found that UVA induced production of prostaglandin (PG) E2 and 3'-5'-cyclic adenosine monophosphate (cAMP), and that this effect was mediated through activation of activating protein-1 (AP-1) and nuclear factor-κB (NF-κB). The UVA effects were antagonized by ethylcysteine, and the effects were found to be mediated by reduced production of PGE2 through the inhibition of JNK and p42/44 MAPK. Taken together, these findings show for the first time that UVA regulates the stemness of hAMSCs and its effects are mediated by downregulation of HIF-1α via the activation of PGE(2)-cAMP signaling. In addition, ethylcysteine may be used as an antagonizing agent to mitigate the effects of UVA.
- Journal of cellular biochemistry.J Cell Biochem.2012 Dec;113(12):3681-91. doi: 10.1002/jcb.24241.
- Ultraviolet A (UVA) irradiation is responsible for a variety of changes in cell biology. The purpose of this study was to investigate the effects of UVA irradiation on the stemness properties of human adipose tissue-derived mesenchymal stem cells (hAMSCs). Furthermore, we examined the UVA-antagonizi
- PMID 22753248
- Biological properties of kinin-releasing enzyme from Trimeresurus okinavensis (himehabu) venom.
- Nikai T, Komori Y, Kato S, Sugihara H.Author information Faculty of Pharmacy, Meijo University, Nagoya, Japan. nikai@meijo-u.ac.jpAbstractA kinin-releasing enzyme was isolated and characterized from the venom of Trimeresurus okinavensis (himehabu) using Sephadex G-100, DEAE-Cellulose, and CM-Cellulose column chromatographies. The kinin-releasing enzyme was homogeneous as demonstrated by a single band on polyacrylamide gel electrophoresis, and isoelectric focusing. The enzyme possesses a molecular weight of 31,000 Da and isoelectric point of 8.2 and consists of 312 total amino acid residues. Specific esterolytic activities of the kinin-releasing enzyme on N-tosyl-L-arginine methyl ester (TAME) and N-benzoyl-L-arginine ethylester (BAEE) were determined to be 235.3 and 111.3 mumol/min/mg, respectively. The enzyme was inhibited by p-APMSF (p-amidinophenylmethanesulfonyl fluoride hydrochloride) and benzamidine. Additionally, the enzyme was found stable to heat treatment. The enzyme cleaved a kininogen analog with the release of bradykinin, resulting in an immediate drop in blood pressure, and contractions of the rat uterus were also observed.
- Journal of natural toxins.J Nat Toxins.1998 Feb;7(1):23-35.
- A kinin-releasing enzyme was isolated and characterized from the venom of Trimeresurus okinavensis (himehabu) using Sephadex G-100, DEAE-Cellulose, and CM-Cellulose column chromatographies. The kinin-releasing enzyme was homogeneous as demonstrated by a single band on polyacrylamide gel electrophore
- PMID 9689600
- Effect of cysteine ethylester hydrochloride (Cystanin) on host defense mechanisms (V): Potentiation of nitroblue tetrazolium reduction and chemiluminescence in macrophages or leukocytes of mice or rats.
- Hisadome M, Fukuda T, Terasawa M.Author information Research Laboratories, Yoshitomi Pharmaceutical Industries, Ltd., Fukuoka, Japan.AbstractL-Cysteine ethylester hydrochloride (Cystanin, ethylcysteine) at doses of 3-30 mg/kg, p.o., potentiated the reduction of nitroblue tetrazolium (NBT) by mouse peritoneal macrophages ex vivo. In in vitro experiments, this drug (30 microM) augmented NBT reduction of mouse peritoneal macrophages induced by opsonized zymosan (OZ). At the same concentration, this drug accelerated the enhancement of the OZ-induced NBT reduction by the addition of concanavalin A, N-formyl-L-methionyl-L-leucyl-L-phenylalanine or phorbol myristate acetate. This enhancing effect of ethylcysteine was completely diminished by the addition of SOD, sodium azide and catalase. In ex vivo experiments, the OZ-induced chemiluminescence of rat peritoneal macrophages and white blood cells was enhanced by the administration of ethylcysteine at doses of 3-10 mg/kg (i.p.) and 3-30 mg/kg (p.o.). In addition, this drug significantly enhanced the lumisphere-induced chemiluminescence of rat peritoneal leukocytes at 30 mg/kg (i.p.), but not the OZ-induced chemiluminescence. In in vitro experiments, this drug (30 microM) did not enhance the OZ-induced chemiluminescence response of rat peritoneal macrophages. These results suggest that ethylcysteine may enhance the intracellular generation of antimicrobial oxidants in macrophages and leukocytes.
- Japanese journal of pharmacology.Jpn J Pharmacol.1990 May;53(1):57-66.
- L-Cysteine ethylester hydrochloride (Cystanin, ethylcysteine) at doses of 3-30 mg/kg, p.o., potentiated the reduction of nitroblue tetrazolium (NBT) by mouse peritoneal macrophages ex vivo. In in vitro experiments, this drug (30 microM) augmented NBT reduction of mouse peritoneal macrophages induced
- PMID 2352378
Japanese Journal
- Effect of cysteine ethylester hydrochloride (Cystanin) on host defense mechanisms (V): Potentiation of nitroblue tetrazolium reduction and chemiluminescence in macrophages or leukocytes of mice or rats.
- HISADOME Masao,FUKUDA Tetsuko,TERASAWA Michio
- The Japanese Journal of Pharmacology 53(1), 57-66, 1990
- … L-Cysteine ethylester hydrochloride (Cystanin®, ethylcysteine) at doses of 3-30 mg/kg, p.o., potentiated the reduction of nitroblue tetrazolium (NBT) by mouse peritoneal macrophages ex vivo. …
- NAID 130000832800
- Drug therapy on Sjoegren's disease and xerostomia. A study by L-cysteine ethylester hydrochloride.:A study by L-cysteine ethylester hydrochloride
- 藤林 孝司,後藤 聡,榎本 昭二
- 日本口腔外科学会雑誌 35(9), 2420-2438, 1989
- … Twenty oral xerosis patients who visited us were treated by L-cysteine ethylester hydrochloride. …
- NAID 130001781011
- Effect of cysteine ethylester hydrochloride (CystaninR) on host defense mechanisms. (IV). Potentiating effects on the function of peritoneal or spleen macrophages.
- HISADOME Masao,KIMURA Yuka,IKEGAMI Kiyoteru,TERASAWA Michio
- The Japanese Journal of Pharmacology 47(4), 379-385, 1988
- … L-Cysteine ethylester hydrochloride (ethylcysteine; …
- NAID 130000832234
Related Links
- chemBlink provides information about L-Cysteine ethyl ester hydrochloride, Ethyl cysteine hydrochloride, CAS #: 868-59-7.
Related Pictures
★リンクテーブル★
| リンク元 | 「エチルシステイン」「cysteine ethylester」「ethyl L-cysteine hydrochloride」「cysteine ethylester hydrochloride」「L-塩酸システインエチルエステル」 |
| 関連記事 | 「cysteine ethylester」「L」「hydrochloride」 |
「エチルシステイン」
- 英
- cysteine ethylester
- 化
- 塩酸L-エチルシステイン、塩酸エチルシステイン、L-塩酸システインエチルエステル、cysteine ethylester hydrochloride、ethyl L-cysteine hydrochloride、L-cysteine ethylester hydrochloride
- 商
- チスタニン
「cysteine ethylester」
- 関
- cysteine ethylester hydrochloride、ethyl L-cysteine hydrochloride、L-cysteine ethylester hydrochloride
「ethyl L-cysteine hydrochloride」
「cysteine ethylester hydrochloride」
「L-塩酸システインエチルエステル」
「cysteine ethylester」
- 関
- cysteine ethylester hydrochloride、ethyl L-cysteine hydrochloride、L-cysteine ethylester hydrochloride
「L」