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1. 赤血球水分量の制御control of red blood cell hydration [show details]
…generated by the Na-K pump to transport ions across the red cell membrane. Because of the dependence upon the Na-K pump, this process is also called secondary active transport. Na-K-Cl cotransport was …
2. プロトンポンプ阻害薬：胃酸分泌が関与する疾患への使用と副作用の概要proton pump inhibitors overview of use and adverse effects in the treatment of acid related disorders [show details]
… salvage therapy regimens for H. pylori infection. Mechanism of action – Proton pump inhibitors (PPIs) inhibit H-K-ATPase, the final step of gastric acid secretion by parietal cells. PPIs are benzimidazole …
3. 腎尿細管性アシドーシスの概要と病態生理、およびカリウムバランスへの影響overview and pathophysiology of renal tubular acidosis and the effect on potassium balance [show details]
…have two different proton-secreting pumps in the luminal membrane: an H-ATPase pump that electrogenically secretes hydrogen ions and an electrically neutral H-K-ATPase pump that secretes hydrogen ions and …
4. 成人における胃食道逆流症の内科的マネージメントmedical management of gastroesophageal reflux disease in adults [show details]
…and inhibiting the hydrogen-potassium (H-K) ATPase pump. PPIs are most effective when taken 30 minutes before the first meal of the day because the amount of H-K-ATPase present in the parietal cell is greatest …
5. 小児における高カリウム血症のマネージメントmanagement of hyperkalemia in children [show details]
…administration drives extracellular potassium into the cells by enhancing the activity of the Na-K ATPase pump in skeletal muscles. Glucose is given concomitantly to prevent hypoglycemia. The effect of insulin…

Japanese Journal

Na, K-ATPase の反応機構とNa, K-ATPase をターゲットとする薬物

鈴木邦明
北海道歯学雑誌 38(1), 16-27, 2017-09
… Na, K-ATPaseはNa-ポンプあるいはNa,K-ポンプと呼ばれる生理機能を担う酵素である．ほぼすべての動物細胞の形質膜に存在し，ATPの加水分解エネルギーを用いてNa+とK+の能動輸送をおこなう．その結果，細胞内外のNa+とK+の濃度勾配および電位差の維持を担い，細胞レベルでは細胞の容積や浸透圧の維持に関与する．特殊化 …
NAID 120006352237