WordNet

the 9th letter of the Roman alphabet (同)i
(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
informal term for information; "give me the gen on your new line of computers"

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1. 原発不明の低分化癌 poorly differentiated cancer from an unknown primary site
2. 急性リンパ芽球性白血病における微小残存病変の検出 detection of minimal residual disease in acute lymphoblastic leukemia
3. 血液悪性腫瘍およびリンパ悪性腫瘍の遺伝的異常 genetic abnormalities in hematologic and lymphoid malignancies
4. 急性骨髄性白血病の分子遺伝学 molecular genetics of acute myeloid leukemia
5. BおよびTリンパ球の正常な発生 normal b and t lymphocyte development

Analysis of cellular phenotype during in vitro immunization of murine splenocytes for generating antigen-specific immunoglobulin.

Inagaki T, Yoshimi T, Kobayashi S, Kawahara M, Nagamune T.SourceInnovative Antibody Engineering Laboratory, Advance Co. Ltd., 5-7 Kobunacho, Chuo-ku, Tokyo 103-8354, Japan; Department of Bioengineering, Graduate School of Engineering, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
Journal of bioscience and bioengineering.J Biosci Bioeng.2013 Mar;115(3):339-45. doi: 10.1016/j.jbiosc.2012.10.008. Epub 2012 Nov 22.
Although various in vitro immunization methods to generate antigen-specific antibodies have been described, a highly effective method that can generate high-affinity immunoglobulins has not yet been reported. Herein, we analyzed a cellular phenotype during in vitro immunization of murine splenocytes
PMID 23177212

Expression of Bcl2L12 in chronic lymphocytic leukemia patients: association with clinical and molecular prognostic markers.

Karan-Djurasevic T, Palibrk V, Zukic B, Spasovski V, Glumac I, Colovic M, Colovic N, Jurisic V, Scorilas A, Pavlovic S, Tosic N.SourceInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Vojvode Stepe 444a, 11010, Belgrade, Serbia.
Medical oncology (Northwood, London, England).Med Oncol.2013 Mar;30(1):405. doi: 10.1007/s12032-012-0405-7. Epub 2013 Jan 5.
Dysregulation of apoptosis is a distinctive feature of chronic lymphocytic leukemia (CLL), although a unique mechanism underlying apoptosis resistance of CLL B lymphocytes has not been identified yet. Aberrant expression as well as genetic and epigenetic alterations of numerous genes involved in dif
PMID 23292833

Analysis of Ig gene hypermutation in Ung(-/-)Polh(-/-) mice suggests that UNG and A:T mutagenesis pathway target different U:G lesions.

Li S, Zhao Y, Wang JY.SourceState Key Laboratory of AgroBiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100094, China.
Molecular immunology.Mol Immunol.2013 Mar;53(3):214-7. doi: 10.1016/j.molimm.2012.08.009. Epub 2012 Sep 4.
The activation-induced cytidine deaminase (AID) initiates Ig gene hypermutation by converting cytosine to uracil (U) and generating a U:G lesion. Genetic and biochemical studies suggest that the AID-triggered U:G lesions are processed by three mutagenic pathways to induce mutations at both C:G and A
PMID 22960197