- 関
- IL6 receptor、interleukin-6 receptor
WordNet
- the 9th letter of the Roman alphabet (同)i
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- 『私は』私が
- iodineの化学記号
- =sense organ / 受信装置
- Illinois
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/12/02 02:20:46」(JST)
[Wiki en表示]
Interleukin 6 receptor |
PDB rendering based on 1n26. |
Available structures |
PDB |
Ortholog search: PDBe, RCSB |
List of PDB id codes |
1N26, 1P9M, 2ARW
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Identifiers |
Symbols |
IL6R; CD126; IL-6R-1; IL-6RA; IL6Q; IL6RA; IL6RQ; gp80 |
External IDs |
OMIM: 147880 MGI: 105304 HomoloGene: 474 GeneCards: IL6R Gene |
Gene Ontology |
Molecular function |
• ciliary neurotrophic factor receptor activity
• interleukin-6 receptor activity
• interleukin-6 receptor binding
• protein binding
• enzyme binding
• interleukin-6 binding
• protein homodimerization activity
• ciliary neurotrophic factor binding
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Cellular component |
• extracellular region
• extracellular space
• plasma membrane
• interleukin-6 receptor complex
• cell surface
• basolateral plasma membrane
• apical plasma membrane
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Biological process |
• hepatic immune response
• neutrophil mediated immunity
• monocyte chemotaxis
• positive regulation of leukocyte chemotaxis
• acute-phase response
• positive regulation of cell proliferation
• positive regulation of activation of Janus kinase activity
• cytokine-mediated signaling pathway
• endocrine pancreas development
• negative regulation of interleukin-8 production
• positive regulation of chemokine production
• positive regulation of interleukin-6 production
• negative regulation of collagen biosynthetic process
• response to cytokine stimulus
• positive regulation of tyrosine phosphorylation of Stat3 protein
• regulation of apoptotic process
• negative regulation of apoptotic process
• positive regulation of MAPK cascade
• positive regulation of osteoblast differentiation
• positive regulation of smooth muscle cell proliferation
• positive regulation of peptidyl-tyrosine phosphorylation
• defense response to Gram-negative bacterium
• defense response to Gram-positive bacterium
• positive regulation of NF-kappaB transcription factor activity
• interleukin-6-mediated signaling pathway
• ciliary neurotrophic factor-mediated signaling pathway
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Sources: Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
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Entrez |
3570 |
16194 |
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Ensembl |
ENSG00000160712 |
ENSMUSG00000027947 |
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UniProt |
P08887 |
P22272 |
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RefSeq (mRNA) |
NM_000565 |
NM_010559 |
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RefSeq (protein) |
NP_000556 |
NP_034689 |
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Location (UCSC) |
Chr 1:
154.38 – 154.44 Mb |
Chr 3:
89.87 – 89.91 Mb |
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PubMed search |
[1] |
[2] |
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Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor.
Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.
In melanocytic cells IL6R gene expression may be regulated by MITF.[1]
Contents
- 1 Structure
- 2 Interactions
- 3 See also
- 4 References
- 5 Further reading
- 6 External links
Structure[edit]
The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[2] IL6R subunit is also shared by many other cytokines.
Interactions[edit]
Interleukin-6 receptor has been shown to interact with Interleukin 6[3] [4] [5] and Ciliary neurotrophic factor.[4][6]
See also[edit]
- Cluster of differentiation
- Tocilizumab, a monoclonal antibody against IL6R
References[edit]
- ^ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
- ^ "Entrez Gene: IL6R interleukin 6 receptor".
- ^ Schwantner, Andreas; Dingley Andrew J, Ozbek Suat, Rose-John Stefan, Grötzinger Joachim (Jan. 2004). "Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy". J. Biol. Chem. (United States) 279 (1): 571–6. doi:10.1074/jbc.M311019200. ISSN 0021-9258. PMID 14557255.
- ^ a b Schuster, Björn; Kovaleva Marina, Sun Yi, Regenhard Petra, Matthews Vance, Grötzinger Joachim, Rose-John Stefan, Kallen Karl-Josef (Mar. 2003). "Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF". J. Biol. Chem. (United States) 278 (11): 9528–35. doi:10.1074/jbc.M210044200. ISSN 0021-9258. PMID 12643274.
- ^ Taga, T; Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T, Hirano T, Kishimoto T (Aug. 1989). "Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130". Cell (UNITED STATES) 58 (3): 573–81. doi:10.1016/0092-8674(89)90438-8. ISSN 0092-8674. PMID 2788034.
- ^ Schooltink, H; Stoyan T, Roeb E, Heinrich P C, Rose-John S (Dec. 1992). "Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes". FEBS Lett. (NETHERLANDS) 314 (3): 280–4. doi:10.1016/0014-5793(92)81489-9. ISSN 0014-5793. PMID 1281789.
Further reading[edit]
- Krause E, Wegenka U, Möller C, et al. (1992). "Gene expression of the high molecular weight proteinase inhibitor alpha 2-macroglobulin.". Biol. Chem. Hoppe-Seyler 373 (7): 509–15. doi:10.1515/bchm3.1992.373.2.509. PMID 1381187.
- Schooltink H, Stoyan T, Roeb E, et al. (1993). "Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes". FEBS Lett. 314 (3): 280–4. doi:10.1016/0014-5793(92)81489-9. PMID 1281789.
- Schooltink H, Stoyan T, Lenz D, et al. (1991). "Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells". Biochem. J. 277 ( Pt 3) (Pt 3): 659–64. PMC 1151293. PMID 1872801.
- Szpirer J, Szpirer C, Rivière M, et al. (1991). "The Interleukin-6-dependent DNA-binding protein gene (transcription factor 5: TCF5) maps to human chromosome 20 and rat chromosome 3, the IL6 receptor locus (IL6R) to human chromosome 1 and rat chromosome 2, and the rat IL6 gene to rat chromosome 4". Genomics 10 (3): 539–46. doi:10.1016/0888-7543(91)90433-F. PMID 1889804.
- Sugita T, Totsuka T, Saito M, et al. (1990). "Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis". J. Exp. Med. 171 (6): 2001–9. doi:10.1084/jem.171.6.2001. PMC 2187962. PMID 2112585.
- Snyers L, De Wit L, Content J (1990). "Glucocorticoid up-regulation of high-affinity interleukin 6 receptors on human epithelial cells". Proc. Natl. Acad. Sci. U.S.A. 87 (7): 2838–42. doi:10.1073/pnas.87.7.2838. PMC 53786. PMID 2157217.
- Hibi M, Murakami M, Saito M, et al. (1991). "Molecular cloning and expression of an IL-6 signal transducer, gp130". Cell 63 (6): 1149–57. doi:10.1016/0092-8674(90)90411-7. PMID 2261637.
- Novick D, Engelmann H, Wallach D, Rubinstein M (1989). "Soluble cytokine receptors are present in normal human urine". J. Exp. Med. 170 (4): 1409–14. doi:10.1084/jem.170.4.1409. PMC 2189483. PMID 2529343.
- Taga T, Hibi M, Hirata Y, et al. (1989). "Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130". Cell 58 (3): 573–81. doi:10.1016/0092-8674(89)90438-8. PMID 2788034.
- Yamasaki K, Taga T, Hirata Y, et al. (1988). "Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor". Science 241 (4867): 825–8. doi:10.1126/science.3136546. PMID 3136546.
- Horiuchi S, Koyanagi Y, Zhou Y, et al. (1994). "Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism". Eur. J. Immunol. 24 (8): 1945–8. doi:10.1002/eji.1830240837. PMID 8056053.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- Tamura T, Udagawa N, Takahashi N, et al. (1994). "Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6". Proc. Natl. Acad. Sci. U.S.A. 90 (24): 11924–8. doi:10.1073/pnas.90.24.11924. PMC 48097. PMID 8265649.
- Kluck PM, Wiegant J, Jansen RP, et al. (1993). "The human interleukin-6 receptor alpha chain gene is localized on chromosome 1 band q21". Hum. Genet. 90 (5): 542–4. doi:10.1007/BF00217455. PMID 8428753.
- Chirmule N, Kalyanaraman VS, Lederman S, et al. (1993). "HIV-gp 160-induced T cell-dependent B cell differentiation. Role of T cell-B cell activation molecule and IL-6". J. Immunol. 150 (6): 2478–86. PMID 8450224.
- Yawata H, Yasukawa K, Natsuka S, et al. (1993). "Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130". EMBO J. 12 (4): 1705–12. PMC 413384. PMID 8467812.
- Pirozzi G, McConnell SJ, Uveges AJ, et al. (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J. Biol. Chem. 272 (23): 14611–6. doi:10.1074/jbc.272.23.14611. PMID 9169421.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Matsuzaki K, Katayama K, Takahashi Y, et al. (1999). "Human osteoclast-like cells are formed from peripheral blood mononuclear cells in a coculture with SaOS-2 cells transfected with the parathyroid hormone (PTH)/PTH-related protein receptor gene". Endocrinology 140 (2): 925–32. doi:10.1210/en.140.2.925. PMID 9927325.
PDB gallery
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1n26: Crystal Structure of the extra-cellular domains of Human Interleukin-6 Receptor alpha chain
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1p9m: Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex
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2arw: The solution structure of the membrane proximal cytokine receptor domain of the human interleukin-6 receptor
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External links[edit]
- IL6R protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Cytokine receptors
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Chemokine receptor
(GPCRs) |
CC |
- CCR1 / CCRL1
- CCR2
- CCRL2
- CCR3
- CCR4
- CCR5
- CCR6
- CCR7
- CCR8
- CCR9
- CCR10
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CXC |
- IL-8
- CXCR3
- CXCR4
- CXCR5
- CXCR6
- CXCR7
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Other |
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TNF receptor |
1-10 |
- TNFRSF1 (CD120)
- TNFRSF1A (CD120a)
- TNFRSF1B (CD120b)
- TNFRSF3 (Lymphotoxin beta receptor)
- TNFRSF4 (CD134)
- TNFRSF5 (CD40)
- TNFRSF6 (FAS)
- TNFRSF6B
- TNFRSF7 (CD27)
- TNFRSF8 (CD30)
- TNFRSF9 (CD137)
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11-20 |
- TNFRSF10A (CD261)
- TNFRSF10B (CD262)
- TNFRSF10C (CD263)
- TNFRSF10D (CD264)
- TNFRSF11A (CD265/RANK)
- TNFRSF11B (Osteoprotegerin)
- TNFRSF12A (CD266)
- TNFRSF13B (CD267)
- TNFRSF13C
- TNFRSF14 (CD268)
- TNFRSF16 (Nerve growth factor receptor)
- TNFRSF17 (CD269)
- TNFRSF18
- TNFRSF19
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21-25 |
- TNFRSF21
- TNFRSF25
- TNFRSF27
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JAK-STAT |
Type I |
γ-chain |
- Interleukin receptors
- IL2R / IL2RA/IL2RB / IL15R
- IL4R / IL13R / IL13RA1 / IL13RA2
- IL7R / IL7RA
- IL9R
- IL21R
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β-chain |
- Interleukin receptors
- IL3R / IL3RA
- IL5R / IL5RA
- GM-CSF
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gp130 |
- Interleukin receptors
- IL6RA
- 11/IL11RA
- 27/IL27RA
- OSMR
- LIFR
- CNTFR
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IL12RB1 |
- Interleukin receptors
- IL12R/IL12RB1/IL12RB2
- IL23R23
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Other |
- hormone receptor: GH
- prolactin
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Type II |
- Interleukin receptors
- IL10R / IL10RA / IL10RB / IL22R / IL22RA1 / IL22RA2
- IL20R / IL20RA / IL20RB
- IL28R
- Interferon receptors
- -α/β / IFNAR1/IFNAR2
- -γ/IFNGR1 / IFNGR2
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Ig superfamily |
- CSF1
- KIT
- IL1
- IL18R / IL18R1
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IL 17 family |
- IL-17
- IL17RA
- IL17RB
- IL17RC
- IL17RD
- IL17RE
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S/T |
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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UpToDate Contents
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English Journal
- Consensus statement on blocking the effects of interleukin-6 and in particular by interleukin-6 receptor inhibition in rheumatoid arthritis and other inflammatory conditions.
- Smolen JS, Schoels MM, Nishimoto N, Breedveld FC, Burmester GR, Dougados M, Emery P, Ferraccioli G, Gabay C, Gibofsky A, Gomez-Reino JJ, Jones G, Kvien TK, Murakami M, Betteridge N, Bingham CO 3rd, Bykerk V, Choy EH, Combe B, Cutolo M, Graninger W, Lanas A, Martin-Mola E, Montecucco C, Ostergaard M, Pavelka K, Rubbert-Roth A, Sattar N, Scholte-Voshaar M, Tanaka Y, Trauner M, Valentini G, Winthrop KL, de Wit M, van der Heijde D.SourceCorrespondence to Professor Josef S Smolen, Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Waehringer Guertel 18-20, Vienna A-1090, Austria; josef.smolen@wienkav.at; josef.smolen@meduniwien.ac.at.
- Annals of the rheumatic diseases.Ann Rheum Dis.2013 Apr;72(4):482-92. doi: 10.1136/annrheumdis-2012-202469. Epub 2012 Nov 21.
- BACKGROUND: Since approval of tocilizumab (TCZ) for treatment of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA), interleukin 6 (IL-6) pathway inhibition was evaluated in trials of TCZ and other agents targeting the IL-6 receptor and ligand in various RA populations and other infla
- PMID 23172750
- p42/p44-MAPK and PI3K are sufficient for IL-6 family cytokines/gp130 to signal to hypertrophy and survival in cardiomyocytes in the absence of JAK/STAT activation.
- Fahmi A, Smart N, Punn A, Jabr R, Marber M, Heads R.SourceKing's College London, British Heart Foundation Centre of Research Excellence, Cardiovascular Division, School of Medicine, UK.
- Cellular signalling.Cell Signal.2013 Apr;25(4):898-909. doi: 10.1016/j.cellsig.2012.12.008. Epub 2012 Dec 23.
- The effect of differential signalling by IL-6 and leukaemia inhibitory factor (LIF) which signal by gp130 homodimerisation or LIFRβ/gp130 heterodimerisation on survival and hypertrophy was studied in neonatal rat cardiomyocytes. Both LIF and IL-6 [in the absence of soluble IL-6 receptor (sIL-6Rα)]
- PMID 23268184
Japanese Journal
- 慢性炎症に伴う貧血のhepcidin抑制による治療
- A single nucleotide polymorphism in 3′-untranslated region contributes to the regulation of toll-like receptor 4 translation
- Sato Kayo,Yoshimura Atsutoshi,Kaneko Takashi,Ukai Takashi,Ozaki Yukio,Nakamura Hirotaka,Li Xinyue,Matsumura Hiroyoshi,Hara Yoshitaka,Ogata Yorimasa
- Journal of Biological Chemistry 287(30), 25163-25172, 2012-07-20
- … In this study the effects of this single nucleotide polymorphism on Toll-like receptor (TLR) 4 expression were investigated. … Peripheral blood mononuclear cells (PBMCs) from the C/C and G/C subjects secreted higher levels of IL-8 in response to lipopolysaccharide (LPS), a TLR4 ligand, than the cells from the G/G subjects. …
- NAID 120004965155
Related Links
- Jak/Stat signaling pathway shown through the IL-6 (or gp130) family of receptors accompanied by a pathway description and selected PubMed references. ... Pathway Description: Jaks and Stats are critical components of many ...
- 米国CST社の日本法人CSTジャパン株式会社【公式サイト】Jak/Stat シグナル経路: IL-6 受容体ファミリー (Jak/Stat Signaling: IL-6 Receptor Family)ページ。高品質の研究用試薬、米国本社の開発研究者による技術的サポートをご提供して ...
- hon p.2 [100%] 668 Fig. 1. A humanized anti IL-6 receptor antibody (MRA) completely inhibits the IL-6 functions by binding the IL-6 receptor both membrane and soluble forms. Fig. 2. IL-6 produced in aŠected lymph nodes induces the
Related Pictures
![Figure 1.](https://1mg.info/0/0/g/0300.jpg)
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![The neuropoietic cytokine family in](https://1mg.info/0/0/g/0303.jpg)
![Figure 3.](https://1mg.info/0/0/g/0304.jpg)
★リンクテーブル★
[★]
- 英
- interleukin-6 receptor、IL-6 receptor
- 関
- インターロイキン6レセプター、IL-6受容体、IL-6レセプター
[★]
- 英
- interleukin-6 receptor、IL-6 receptor
- 関
- インターロイキン6受容体、IL-6受容体、IL-6レセプター
[★]
- 英
- IL-6 receptor
- 関
- インターロイキン6受容体、インターロイキン6レセプター、IL-6レセプター
[★]
- 英
- IL-6 receptor
- 関
- インターロイキン6受容体、インターロイキン6レセプター、IL-6受容体
[★]
- 関
- IL-6 receptor、IL6 receptor
[★]
[★]