IL-6 receptor

• インターロイキン6受容体、インターロイキン6レセプター、IL-6受容体、IL-6レセプター

関

IL6 receptor、interleukin-6 receptor

WordNet

1. the 9th letter of the Roman alphabet (同)i
2. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

PrepTutorEJDIC

1. 『私は』私が
2. iodineの化学記号
3. =sense organ / 受信装置
4. Illinois

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/02 02:20:46」(JST)

wiki en

[Wiki en表示]

Interleukin 6 receptor
PDB rendering based on 1n26.
Available structures PDB Ortholog search: PDBe, RCSB List of PDB id codes 1N26, 1P9M, 2ARW
Identifiers
Symbols	IL6R; CD126; IL-6R-1; IL-6RA; IL6Q; IL6RA; IL6RQ; gp80
External IDs	OMIM: 147880 MGI: 105304 HomoloGene: 474 GeneCards: IL6R Gene
Gene Ontology Molecular function • ciliary neurotrophic factor receptor activity • interleukin-6 receptor activity • interleukin-6 receptor binding • protein binding • enzyme binding • interleukin-6 binding • protein homodimerization activity • ciliary neurotrophic factor binding Cellular component • extracellular region • extracellular space • plasma membrane • interleukin-6 receptor complex • cell surface • basolateral plasma membrane • apical plasma membrane Biological process • hepatic immune response • neutrophil mediated immunity • monocyte chemotaxis • positive regulation of leukocyte chemotaxis • acute-phase response • positive regulation of cell proliferation • positive regulation of activation of Janus kinase activity • cytokine-mediated signaling pathway • endocrine pancreas development • negative regulation of interleukin-8 production • positive regulation of chemokine production • positive regulation of interleukin-6 production • negative regulation of collagen biosynthetic process • response to cytokine stimulus • positive regulation of tyrosine phosphorylation of Stat3 protein • regulation of apoptotic process • negative regulation of apoptotic process • positive regulation of MAPK cascade • positive regulation of osteoblast differentiation • positive regulation of smooth muscle cell proliferation • positive regulation of peptidyl-tyrosine phosphorylation • defense response to Gram-negative bacterium • defense response to Gram-positive bacterium • positive regulation of NF-kappaB transcription factor activity • interleukin-6-mediated signaling pathway • ciliary neurotrophic factor-mediated signaling pathway Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	3570	16194
Ensembl	ENSG00000160712	ENSMUSG00000027947
UniProt	P08887	P22272
RefSeq (mRNA)	NM_000565	NM_010559
RefSeq (protein)	NP_000556	NP_034689
Location (UCSC)	Chr 1: 154.38 – 154.44 Mb	Chr 3: 89.87 – 89.91 Mb
PubMed search	[1]	[2]

Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor.

Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.

In melanocytic cells IL6R gene expression may be regulated by MITF.

Structure

The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported. IL6R subunit is also shared by many other cytokines.

Interactions

Interleukin-6 receptor has been shown to interact with Interleukin 6 and Ciliary neurotrophic factor.

See also

• Cluster of differentiation
• Tocilizumab, a monoclonal antibody against IL6R

References

Further reading

• Krause E, Wegenka U, Möller C, et al. (1992). "Gene expression of the high molecular weight proteinase inhibitor alpha 2-macroglobulin.". Biol. Chem. Hoppe-Seyler 373 (7): 509–15. doi:10.1515/bchm3.1992.373.2.509. PMID 1381187. 
• Schooltink H, Stoyan T, Roeb E, et al. (1993). "Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes". FEBS Lett. 314 (3): 280–4. doi:10.1016/0014-5793(92)81489-9. PMID 1281789. 
• Schooltink H, Stoyan T, Lenz D, et al. (1991). "Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells". Biochem. J. 277 ( Pt 3) (Pt 3): 659–64. PMC 1151293. PMID 1872801. 
• Szpirer J, Szpirer C, Rivière M, et al. (1991). "The Interleukin-6-dependent DNA-binding protein gene (transcription factor 5: TCF5) maps to human chromosome 20 and rat chromosome 3, the IL6 receptor locus (IL6R) to human chromosome 1 and rat chromosome 2, and the rat IL6 gene to rat chromosome 4". Genomics 10 (3): 539–46. doi:10.1016/0888-7543(91)90433-F. PMID 1889804. 
• Sugita T, Totsuka T, Saito M, et al. (1990). "Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis". J. Exp. Med. 171 (6): 2001–9. doi:10.1084/jem.171.6.2001. PMC 2187962. PMID 2112585. 
• Snyers L, De Wit L, Content J (1990). "Glucocorticoid up-regulation of high-affinity interleukin 6 receptors on human epithelial cells". Proc. Natl. Acad. Sci. U.S.A. 87 (7): 2838–42. doi:10.1073/pnas.87.7.2838. PMC 53786. PMID 2157217. 
• Hibi M, Murakami M, Saito M, et al. (1991). "Molecular cloning and expression of an IL-6 signal transducer, gp130". Cell 63 (6): 1149–57. doi:10.1016/0092-8674(90)90411-7. PMID 2261637. 
• Novick D, Engelmann H, Wallach D, Rubinstein M (1989). "Soluble cytokine receptors are present in normal human urine". J. Exp. Med. 170 (4): 1409–14. doi:10.1084/jem.170.4.1409. PMC 2189483. PMID 2529343. 
• Taga T, Hibi M, Hirata Y, et al. (1989). "Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130". Cell 58 (3): 573–81. doi:10.1016/0092-8674(89)90438-8. PMID 2788034. 
• Yamasaki K, Taga T, Hirata Y, et al. (1988). "Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor". Science 241 (4867): 825–8. doi:10.1126/science.3136546. PMID 3136546. 
• Horiuchi S, Koyanagi Y, Zhou Y, et al. (1994). "Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism". Eur. J. Immunol. 24 (8): 1945–8. doi:10.1002/eji.1830240837. PMID 8056053. 
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• Tamura T, Udagawa N, Takahashi N, et al. (1994). "Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6". Proc. Natl. Acad. Sci. U.S.A. 90 (24): 11924–8. doi:10.1073/pnas.90.24.11924. PMC 48097. PMID 8265649. 
• Kluck PM, Wiegant J, Jansen RP, et al. (1993). "The human interleukin-6 receptor alpha chain gene is localized on chromosome 1 band q21". Hum. Genet. 90 (5): 542–4. doi:10.1007/BF00217455. PMID 8428753. 
• Chirmule N, Kalyanaraman VS, Lederman S, et al. (1993). "HIV-gp 160-induced T cell-dependent B cell differentiation. Role of T cell-B cell activation molecule and IL-6". J. Immunol. 150 (6): 2478–86. PMID 8450224. 
• Yawata H, Yasukawa K, Natsuka S, et al. (1993). "Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130". EMBO J. 12 (4): 1705–12. PMC 413384. PMID 8467812. 
• Pirozzi G, McConnell SJ, Uveges AJ, et al. (1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". J. Biol. Chem. 272 (23): 14611–6. doi:10.1074/jbc.272.23.14611. PMID 9169421. 
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• Matsuzaki K, Katayama K, Takahashi Y, et al. (1999). "Human osteoclast-like cells are formed from peripheral blood mononuclear cells in a coculture with SaOS-2 cells transfected with the parathyroid hormone (PTH)/PTH-related protein receptor gene". Endocrinology 140 (2): 925–32. doi:10.1210/en.140.2.925. PMID 9927325. 

External links

• IL6R protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. IL - 1、IL - 6、およびRANKLを抑制する生物学的製剤の関節リウマチ
  におけるランダム化臨床試験 randomized clinical trials in rheumatoid arthritis of biologic agents that inhibit il 1 il 6 and rankl
• 2. リウマチ性疾患における生物学的製剤の概要 overview of biologic agents in the rheumatic diseases
• 3. 心血管疾患と同等のリスクと確立した危険因子の概要 overview of the risk equivalents and established risk factors for cardiovascular disease
• 4. リウマチ性疾患におけるサイトカインネットワーク：治療の意味 cytokine networks in rheumatic diseases implications for therapy
• 5. 多発性骨髄腫の病理生物学 pathobiology of multiple myeloma

English Journal

• Consensus statement on blocking the effects of interleukin-6 and in particular by interleukin-6 receptor inhibition in rheumatoid arthritis and other inflammatory conditions.

• Smolen JS, Schoels MM, Nishimoto N, Breedveld FC, Burmester GR, Dougados M, Emery P, Ferraccioli G, Gabay C, Gibofsky A, Gomez-Reino JJ, Jones G, Kvien TK, Murakami M, Betteridge N, Bingham CO 3rd, Bykerk V, Choy EH, Combe B, Cutolo M, Graninger W, Lanas A, Martin-Mola E, Montecucco C, Ostergaard M, Pavelka K, Rubbert-Roth A, Sattar N, Scholte-Voshaar M, Tanaka Y, Trauner M, Valentini G, Winthrop KL, de Wit M, van der Heijde D.SourceCorrespondence to Professor Josef S Smolen, Division of Rheumatology, Department of Medicine 3, Medical University of Vienna, Waehringer Guertel 18-20, Vienna A-1090, Austria; josef.smolen@wienkav.at; josef.smolen@meduniwien.ac.at.
• Annals of the rheumatic diseases.Ann Rheum Dis.2013 Apr;72(4):482-92. doi: 10.1136/annrheumdis-2012-202469. Epub 2012 Nov 21.
• BACKGROUND: Since approval of tocilizumab (TCZ) for treatment of rheumatoid arthritis (RA) and juvenile idiopathic arthritis (JIA), interleukin 6 (IL-6) pathway inhibition was evaluated in trials of TCZ and other agents targeting the IL-6 receptor and ligand in various RA populations and other infla
• PMID 23172750

• p42/p44-MAPK and PI3K are sufficient for IL-6 family cytokines/gp130 to signal to hypertrophy and survival in cardiomyocytes in the absence of JAK/STAT activation.

• Fahmi A, Smart N, Punn A, Jabr R, Marber M, Heads R.SourceKing's College London, British Heart Foundation Centre of Research Excellence, Cardiovascular Division, School of Medicine, UK.
• Cellular signalling.Cell Signal.2013 Apr;25(4):898-909. doi: 10.1016/j.cellsig.2012.12.008. Epub 2012 Dec 23.
• The effect of differential signalling by IL-6 and leukaemia inhibitory factor (LIF) which signal by gp130 homodimerisation or LIFRβ/gp130 heterodimerisation on survival and hypertrophy was studied in neonatal rat cardiomyocytes. Both LIF and IL-6 [in the absence of soluble IL-6 receptor (sIL-6Rα)]
• PMID 23268184

Japanese Journal

• 慢性炎症に伴う貧血のhepcidin抑制による治療

• 寺田 芳樹,日野 雅之
• 血液内科 65(4), 591-598, 2012-10
• NAID 40019489694

• A single nucleotide polymorphism in 3′-untranslated region contributes to the regulation of toll-like receptor 4 translation

• Sato Kayo,Yoshimura Atsutoshi,Kaneko Takashi,Ukai Takashi,Ozaki Yukio,Nakamura Hirotaka,Li Xinyue,Matsumura Hiroyoshi,Hara Yoshitaka,Ogata Yorimasa
• Journal of Biological Chemistry 287(30), 25163-25172, 2012-07-20
• … In this study the effects of this single nucleotide polymorphism on Toll-like receptor (TLR) 4 expression were investigated. … Peripheral blood mononuclear cells (PBMCs) from the C/C and G/C subjects secreted higher levels of IL-8 in response to lipopolysaccharide (LPS), a TLR4 ligand, than the cells from the G/G subjects. …
• NAID 120004965155

Related Links

• Signaling Pathways: Jak/Stat Signaling: IL-6 Receptor Family

Jak/Stat signaling pathway shown through the IL-6 (or gp130) family of receptors accompanied by a pathway description and selected PubMed references. ... Pathway Description: Jaks and Stats are critical components of many ...

• CSTジャパン - Jak/Stat シグナル経路: IL-6 受容体ファミリー ...

米国CST社の日本法人CSTジャパン株式会社【公式サイト】Jak/Stat シグナル経路: IL-6 受容体ファミリー (Jak/Stat Signaling: IL-6 Receptor Family)ページ。高品質の研究用試薬、米国本社の開発研究者による技術的サポートをご提供して ...

• 抗体製薬を用いた Interleukin 6 阻害療法から学んだ ...

hon p.2 [100%] 668 Fig. 1. A humanized anti IL-6 receptor antibody (MRA) completely inhibits the IL-6 functions by binding the IL-6 receptor both membrane and soluble forms. Fig. 2. IL-6 produced in aŠected lymph nodes induces the

Related Pictures

---

★リンクテーブル★

リンク元	「インターロイキン6受容体」「インターロイキン6レセプター」「IL-6受容体」「IL-6レセプター」「interleukin-6 receptor」
関連記事	「I」「IL」

「インターロイキン6受容体」

　　[★]

英

interleukin-6 receptor、IL-6 receptor

関

インターロイキン6レセプター、IL-6受容体、IL-6レセプター

「インターロイキン6レセプター」

　　[★]

英

interleukin-6 receptor、IL-6 receptor

関

インターロイキン6受容体、IL-6受容体、IL-6レセプター

「IL-6受容体」

　　[★]

英

IL-6 receptor

関

インターロイキン6受容体、インターロイキン6レセプター、IL-6レセプター

「IL-6レセプター」

　　[★]

英

IL-6 receptor

関

インターロイキン6受容体、インターロイキン6レセプター、IL-6受容体

「interleukin-6 receptor」

　　[★]

• インターロイキン6受容体、インターロイキン6レセプター

関

IL-6 receptor、IL6 receptor

「I」

　　[★]

• イソロイシン isoleucine
• イノシン inosine
• 阻害剤 inhibitor
• iodine
• ヨード iodide
• I因子 factor I

　 　 　

「IL」

　　[★]

• インターロイキン interleukin
• indeterminate leprosy