WordNet

a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system

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=sense organ / 受信装置

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/05/20 23:21:48」(JST)

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Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor.

Function

Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.

In melanocytic cells IL6R gene expression may be regulated by MITF.^[1]

Structure

The IL6 receptor is a protein complex consisting of an IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported.^[2] IL6R subunit is also shared by many other cytokines.

Interactions

Interleukin-6 receptor has been shown to interact with Interleukin 6^[3] ^[4] ^[5] and Ciliary neurotrophic factor.^[4]^[6]

References

^ Hoek KS, Schlegel NC, Eichhoff OM, Widmer DS, Praetorius C, Einarsson SO et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.
^ "Entrez Gene: IL6R interleukin 6 receptor".
^ Schwantner A, Dingley AJ, Ozbek S, Rose-John S, Grötzinger J (Jan 2004). "Direct determination of the interleukin-6 binding epitope of the interleukin-6 receptor by NMR spectroscopy". J. Biol. Chem. 279 (1): 571–6. doi:10.1074/jbc.M311019200. PMID 14557255.
^ ^a ^b Schuster B, Kovaleva M, Sun Y, Regenhard P, Matthews V, Grötzinger J et al. (Mar 2003). "Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF". J. Biol. Chem. 278 (11): 9528–35. doi:10.1074/jbc.M210044200. PMID 12643274.
^ Taga T, Hibi M, Hirata Y, Yamasaki K, Yasukawa K, Matsuda T et al. (Aug 1989). "Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130". Cell 58 (3): 573–81. doi:10.1016/0092-8674(89)90438-8. PMID 2788034.
^ Schooltink H, Stoyan T, Roeb E, Heinrich PC, Rose-John S (Dec 1992). "Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes". FEBS Lett. 314 (3): 280–4. doi:10.1016/0014-5793(92)81489-9. PMID 1281789.

External links

IL6R protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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5. 高カルシウム血症の原因 etiology of hypercalcemia

English Journal

Stable over-expression of PPARβ/δ and PPARγ to examine receptor signaling in human HaCaT keratinocytes.

Borland MG, Khozoie C, Albrecht PP, Zhu B, Lee C, Lahoti TS, Gonzalez FJ, Peters JM.SourceDepartment of Veterinary and Biomedical Sciences, The Center of Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, PA 16802, USA; Graduate Program in Biochemistry, Microbiology, and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Cellular signalling.Cell Signal.2011 Dec;23(12):2039-50. Epub 2011 Aug 4.
Peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) function and receptor cross-talk with other nuclear receptors, including PPARγ and retinoic acid receptors (RARs), was examined using stable human HaCaT keratinocyte cell lines over-expressing PPARβ/δ or PPARγ. Enhanced ligand-induced
PMID 21843636

Receptor-Interacting Protein 2 Controls Pulmonary Host Defense to Escherichia coli Infection via the Regulation of Interleukin-17A.

Balamayooran T, Batra S, Balamayooran G, Cai S, Kobayashi KS, Flavell RA, Jeyaseelan S.SourcePathobiological Sciences and Medicine, Louisiana State University, Baton Rouge, LA 70803. jey@lsu.edu.
Infection and immunity.Infect Immun.2011 Nov;79(11):4588-99. Epub 2011 Aug 15.
Recognition of microbial patterns by host receptors is the first step in a multistep sequence leading to neutrophil-dependent host resistance. Although the role of membrane-bound sensors in bacterial recognition has been examined in detail, the importance of cytosolic sensors in the lungs is largely
PMID 21844230

Japanese Journal

Laboratory investigation: Regulation of soluble interleukin-6 (IL-6) receptor release from corneal epithelial cells and its role in the ocular surface

Sugaya Satoshi,Sakimoto Tohru,Shoji Jun [他]
Japanese journal of ophthalmology 55(3), 277-282, 2011-05
NAID 40018854698

Effects of Chondroitin Sulfate and Its Oligosaccharides on Toll-Like Receptor-Mediated IL-6 Secretion by Macrophage-Like J774.1 Cells

JIN Miao,IWAMOTO Taku,YAMADA Kiyoshi,SATSU Hideo,TOTSUKA Mamoru,SHIMIZU Makoto
Bioscience, Biotechnology, and Biochemistry 75(7), 1283-1289, 2011
… The effects of two types of chondroitin sulphate (CS), CS-A and CS-C, their oligosaccharides (oligo-CSs), and disaccharides (Di-CSs) on toll-like receptor (TLR)-mediated secretion of interleukin (IL)-6 were compared using macrophage-like cell line J774.1. … IL-6 secretion in the J774.1 cells was markedly increased by Pam3CS4, LPS, and CpG, the ligands to TLR1/2, 4, and 9 respectively. …
NAID 130000940512

Related Pictures

★リンクテーブル★

リンク元	「IL-6 receptor」「インターロイキン6受容体」「インターロイキン6レセプター」
拡張検索	「interleukin-6 receptor alpha subunit」
関連記事	「interleukin」「interleukins」

「IL-6 receptor」

Interleukin 6 receptor
	; PDB rendering based on 1n26.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1N26, 1N2Q, 1P9M, 2ARW
Identifiers
Symbols	IL6R ; CD126; IL-6R-1; IL-6RA; IL6Q; IL6RA; IL6RQ; gp80
External IDs	OMIM: 147880 MGI: 105304 HomoloGene: 474 IUPHAR: 1708 GeneCards: IL6R Gene
Gene ontology
Molecular function	• ciliary neurotrophic factor receptor activity; • interleukin-6 receptor activity; • interleukin-6 receptor binding; • protein binding; • enzyme binding; • interleukin-6 binding; • protein homodimerization activity; • ciliary neurotrophic factor binding;
Cellular component	• extracellular region; • extracellular space; • plasma membrane; • interleukin-6 receptor complex; • cell surface; • basolateral plasma membrane; • apical plasma membrane;
Biological process	• hepatic immune response; • neutrophil mediated immunity; • monocyte chemotaxis; • positive regulation of leukocyte chemotaxis; • acute-phase response; • positive regulation of cell proliferation; • positive regulation of activation of Janus kinase activity; • cytokine-mediated signaling pathway; • endocrine pancreas development; • negative regulation of interleukin-8 production; • positive regulation of chemokine production; • positive regulation of interleukin-6 production; • negative regulation of collagen biosynthetic process; • response to cytokine; • positive regulation of tyrosine phosphorylation of Stat3 protein; • positive regulation of MAPK cascade; • positive regulation of osteoblast differentiation; • positive regulation of smooth muscle cell proliferation; • positive regulation of peptidyl-tyrosine phosphorylation; • defense response to Gram-negative bacterium; • defense response to Gram-positive bacterium; • positive regulation of NF-kappaB transcription factor activity; • interleukin-6-mediated signaling pathway; • ciliary neurotrophic factor-mediated signaling pathway; • extrinsic apoptotic signaling pathway;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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