インターロイキン18受容体、IL-18受容体、IL-18レセプター

関: interleukin-18 receptor

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the 9th letter of the Roman alphabet (同)i
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/07 16:21:59」(JST)

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The interleukin-18 receptor (IL-18R) is an interleukin receptor of the immunoglobulin superfamily.^[1]^[2] IL-18R is a heteromeric complex of alpha- and beta-chains encoded by the genes IL18R1 and IL18RAP respectively.

Endometrial IL-18 receptor mRNA and the ratio of IL-18 binding protein to interleukin 18 are significantly increased in adenomyosis patients in comparison to normal people, indicating a role in its pathogenesis.^[3]

References

^ Sergi B, Penttila I (2004). "Interleukin 18 receptor". J. Biol. Regul. Homeost. Agents 18 (1): 55–61. PMID 15323361.
^ Wu C, Sakorafas P, Miller R, McCarthy D, Scesney S, Dixon R, Ghayur T (2003). "IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction". J. Immunol. 170 (11): 5571–7. doi:10.4049/jimmunol.170.11.5571. PMID 12759435.
^ Huang, H.; Yu, H.; Chan, S.; Lee, C.; Wang, H.; Soong, Y. (2010). "Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients". Fertility and Sterility 94 (1): 33–39. doi:10.1016/j.fertnstert.2009.01.132. PMID 19394601.

External links

Receptors, Interleukin-18 at the US National Library of Medicine Medical Subject Headings (MeSH)

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

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1. クリオピリン関連周期性発熱症候群および関連疾患 cryopyrin associated periodic syndromes and related disorders
2. リウマチ性疾患におけるサイトカインネットワーク：治療の意味 cytokine networks in rheumatic diseases implications for therapy
3. サルコイドーシスの病因 pathogenesis of sarcoidosis
4. 薬物アレルギー：病因 drug allergy pathogenesis
5. 心血管疾患と同等のリスクと確立した危険因子の概要 overview of the risk equivalents and established risk factors for cardiovascular disease

English Journal

Interleukin-18 Activates Skeletal Muscle AMPK and Reduces Weight Gain and Insulin Resistance in Mice.

Lindegaard B, Matthews VB, Brandt C, Hojman P, Allen TL, Estevez E, Watt MJ, Bruce CR, Mortensen OH, Syberg S, Rudnicka C, Abildgaard J, Pilegaard H, Hidalgo J, Ditlevsen S, Alsted TJ, Madsen AN, Pedersen BK, Febbraio MA.SourceThe Centre of Inflammation and Metabolism, Rigshospitalet, Copenhagen, Denmark.
Diabetes.Diabetes.2013 Sep;62(9):3064-74. doi: 10.2337/db12-1095. Epub 2013 May 13.
Circulating interleukin (IL)-18 is elevated in obesity, but paradoxically causes hypophagia. We hypothesized that IL-18 may attenuate high-fat diet (HFD)-induced insulin resistance by activating AMP-activated protein kinase (AMPK). We studied mice with a global deletion of the α-isoform of the IL-1
PMID 23670974

Increased Serum Levels of Soluble IL-18 Receptor Complex in Patients with Allergic Asthma.

Imaoka H, Takenaka SI, Kawayama T, Oda H, Kaku Y, Matsuoka M, Sakazaki Y, O'Byrne PM, Hoshino T.SourceDivision of Respirology, Neurology, and Rheumatology, The First Department of Medicine, Kurume University School of Medicine, Fukuoka, Japan.
Allergology international : official journal of the Japanese Society of Allergology.Allergol Int.2013 Aug 25. [Epub ahead of print]
PMID 23963474

Pathophysiological mechanisms involving aggressive islet cell destruction in fulminant type 1 diabetes [Review].

Tanaka S, Aida K, Nishida Y, Kobayashi T.SourceThird Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo 409-3898, Japan.
Endocrine journal.Endocr J.2013 Jul 30;60(7):837-45. Epub 2013 Jun 18.
Fulminant type 1 diabetes is characterized by a rapid onset of severe hyperglycemia and ketoacidosis, with subsequent poor prognosis of diabetic complications. This review summarizes new findings related to the pathophysiology of accelerated β-cell failure in fulminant type 1 diabetes. Immunohistol
PMID 23774118

Japanese Journal

The structural basis for receptor recognition of human interleukin-18.

Tsutsumi Naotaka,Kimura Takeshi,Arita Kyohei,Ariyoshi Mariko,Ohnishi Hidenori,Yamamoto Takahiro,Zuo Xiaobing,Maenaka Katsumi,Park Enoch Y,Kondo Naomi,Shirakawa Masahiro,Tochio Hidehito,Kato Zenichiro
Nature communications 5, 2014-12-15
… 免疫・神経難治疾患の治療薬開発を促進するインターロイキン18複合体立体構造を解明. … 2014-12-16.Interleukin (IL)-18 is a proinflammatory cytokine that belongs to the IL-1 family and plays an important role in inflammation. …
NAID 120005540871

Increased Interleukin-18 in the Gingival Tissues Evokes Chronic Periodontitis after Bacterial Infection

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The Tohoku Journal of Experimental Medicine 232(3), 215-222, 2014
… Recently, several studies have shown a close relationship between increased interleukin-18 (IL-18) levels and the pathogenesis of chronic periodontitis, a major cause of tooth loss. … However, it has yet to be shown whether chronic periodontitis results from or causes an increase in IL-18 after bacterial infection. …
NAID 130004822404

Identification of a novel type 2 innate immunocyte with the ability to enhance IgE production.

Fukuoka Ayumi,Futatsugi-Yumikura Shizue,Takahashi Suzuka,Kazama Hirotaka,Iyoda Tomonori,Yoshimoto Tomohiro,Inaba Kayo,Nakanishi Kenji,Yonehara Shin
International immunology 25(6), 373-382, 2013-06
… Fas (CD95), a member of the tumor necrosis factor receptor superfamily, mediates apoptosis-inducing signals in its expressing cells, especially in self-reactive cells. … Here, we found a novel type of immunocyte in the spleen of BALB/c Fas(-/-) mice, which enhanced the production of IgE by B cells in the presence of IL-4 and CD40 signaling in vitro. … However, they did not express c-Kit, IL-7R and IL-33R (T1/ST2), important markers of type 2 innate lymphoid cells. …
NAID 120005474479

「インターロイキン18受容体」

interleukin 18 receptor accessory protein
Identifiers
Symbol	IL18RAP
Alt. symbols	AcPL, CD218b
Entrez	8807
HUGO	5989
OMIM	604509
RefSeq	NM_003853
UniProt	O95256
Other data
Locus	Chr. 2 p24.3-24.1

interleukin 18 receptor 1
Identifiers
Symbol	IL18R1
Alt. symbols	IL1RRP, IL-1Rrp, CD218a
Entrez	8809
HUGO	5988
OMIM	604494
RefSeq	NM_003855
UniProt	Q13478
Other data
Locus	Chr. 2 q12

　　[★]

英: interleukin-18 receptor、IL-18 receptor
関: インターロイキン18レセプター、IL-18受容体、IL-18レセプター

「interleukin-18 receptor」

　　[★]

インターロイキン18受容体、インターロイキン18レセプター

関: IL-18 receptor

「IL-18受容体」

　　[★]

英: IL-18 receptor
関: インターロイキン18受容体、IL-18レセプター

「IL-18レセプター」

　　[★]

英: IL-18 receptor
関: インターロイキン18受容体、IL-18受容体

「I」

　　[★]

「IL」

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[pmid15323361-1] Sergi B, Penttila I (2004). "Interleukin 18 receptor". J. Biol. Regul. Homeost. Agents 18 (1): 55–61. PMID 15323361.

[pmid12759435-2] Wu C, Sakorafas P, Miller R, McCarthy D, Scesney S, Dixon R, Ghayur T (2003). "IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction". J. Immunol. 170 (11): 5571–7. doi:10.4049/jimmunol.170.11.5571. PMID 12759435.

[3] Huang, H.; Yu, H.; Chan, S.; Lee, C.; Wang, H.; Soong, Y. (2010). "Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients". Fertility and Sterility 94 (1): 33–39. doi:10.1016/j.fertnstert.2009.01.132. PMID 19394601.

リンク元	「インターロイキン18受容体」「interleukin-18 receptor」「IL-18受容体」「IL-18レセプター」
関連記事	「I」「IL」

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案内

IL-18 receptor