- 関
- IL-18 receptor
WordNet
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system
PrepTutorEJDIC
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/03 02:31:17」(JST)
[Wiki en表示]
| interleukin 18 receptor 1 |
| Identifiers |
| Symbol |
IL18R1 |
| Alt. symbols |
IL1RRP, IL-1Rrp, CD218a |
| Entrez |
8809 |
| HUGO |
5988 |
| OMIM |
604494 |
| RefSeq |
NM_003855 |
| UniProt |
Q13478 |
| Other data |
| Locus |
Chr. 2 q12 |
| interleukin 18 receptor accessory protein |
| Identifiers |
| Symbol |
IL18RAP |
| Alt. symbols |
AcPL, CD218b |
| Entrez |
8807 |
| HUGO |
5989 |
| OMIM |
604509 |
| RefSeq |
NM_003853 |
| UniProt |
O95256 |
| Other data |
| Locus |
Chr. 2 p24.3-24.1 |
The interleukin-18 receptor (IL-18R) is an interleukin receptor of the immunoglobulin superfamily.[1][2] IL-18R is a heteromeric complex of alpha- and beta-chains encoded by the genes IL18R1 and IL18RAP respectively.
Endometrial IL-18 receptor mRNA and the ratio of IL-18 binding protein to interleukin 18 are significantly increased in adenomyosis patients in comparison to normal people, indicating a role in its pathogenesis.[3]
References
- ^ Sergi B, Penttila I (2004). "Interleukin 18 receptor". J. Biol. Regul. Homeost. Agents 18 (1): 55–61. PMID 15323361.
- ^ Wu C, Sakorafas P, Miller R, McCarthy D, Scesney S, Dixon R, Ghayur T (2003). "IL-18 receptor beta-induced changes in the presentation of IL-18 binding sites affect ligand binding and signal transduction". J. Immunol. 170 (11): 5571–7. doi:10.4049/jimmunol.170.11.5571. PMID 12759435.
- ^ Huang, H.; Yu, H.; Chan, S.; Lee, C.; Wang, H.; Soong, Y. (2010). "Eutopic endometrial interleukin-18 system mRNA and protein expression at the level of endometrial-myometrial interface in adenomyosis patients". Fertility and Sterility 94 (1): 33–39. doi:10.1016/j.fertnstert.2009.01.132. PMID 19394601. edit
External links
- Receptors, Interleukin-18 at the US National Library of Medicine Medical Subject Headings (MeSH)
UpToDate Contents
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English Journal
- NLRC4 inflammasomes in dendritic cells regulate noncognate effector function by memory CD8⁺ T cells.
- Kupz A, Guarda G, Gebhardt T, Sander LE, Short KR, Diavatopoulos DA, Wijburg OL, Cao H, Waithman JC, Chen W, Fernandez-Ruiz D, Whitney PG, Heath WR, Curtiss R 3rd, Tschopp J, Strugnell RA, Bedoui S.SourceDepartment of Microbiology and Immunology, The University of Melbourne, Parkville, Victoria, Australia.
- Nature immunology.Nat Immunol.2012 Jan 8;13(2):162-9. doi: 10.1038/ni.2195.
- Memory T cells exert antigen-independent effector functions, but how these responses are regulated is unclear. We discovered an in vivo link between flagellin-induced NLRC4 inflammasome activation in splenic dendritic cells (DCs) and host protective interferon-γ (IFN-γ) secretion by noncognate mem
- PMID 22231517
- Genetic and genomic approaches to asthma: new insights for the origins.
- Zhang Y, Moffatt MF, Cookson WO.SourceMolecular Genetics Group, Division of Respiratory Sciences, Imperial College London, Dovehouse Street, London, UK. y.zhang@imperial.ac.uk
- Current opinion in pulmonary medicine.Curr Opin Pulm Med.2012 Jan;18(1):6-13.
- PURPOSE OF REVIEW: The aim is to update current understanding of the genes identified by the recent genome-wide association studies (GWASs) of asthma and its associated traits. The review also discusses how to dissect the functional roles of novel genes in future research.RECENT FINDINGS: More than
- PMID 22112999
Japanese Journal
- 〈Originals〉Interleukin-18 receptor α has differing roles in the systemic response and renal inflammation in lipopolysaccharide-induced acute kidney injury
- ACTA MEDICA KINKI UNIVERSITY = The Kinki University Medical Association 40(1), 15-22, 2015-06-01
- NAID 120005736860
- Effects of combined aerobic and resistance training on the glycolipid metabolism and inflammation levels in type 2 diabetes mellitus
- The structural basis for receptor recognition of human interleukin-18.
Related Links
- IL-18 RECEPTOR (IL-18R) AND SIGNALING Like that of IL-1, the IL-18R complex is a heterodimer containing an α (IL-1Rrp) chain responsible for extracellular binding of IL-18 and a nonbinding, signal-transducing β ...
- 1. J Biol Regul Homeost Agents. 2004 Jan-Mar;18(1):55-61. Interleukin 18 receptor. Sergi B, Penttila I. Child Health Research Institute, North Adelaide, Australia. PMID: 15323361 [PubMed - indexed for MEDLINE] Publication Types:
★リンクテーブル★
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- 英
- interleukin-18 receptor、IL-18 receptor
- 関
- インターロイキン18レセプター、IL-18受容体、IL-18レセプター
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- 関
- interleukin-18 receptor
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- 英
- interleukin-18 receptor
- 関
- インターロイキン18受容体
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インターロイキン IL
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インターロイキン IL