インターロイキン13受容体、IL-13受容体、IL-13レセプター

関: interleukin-13 receptor

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the 9th letter of the Roman alphabet (同)i
a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response

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iodineの化学記号
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/12/18 20:34:25」(JST)

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The interleukin-13 receptor is a type I cytokine receptor, binding Interleukin-13. It consists of two subunits, encoded by IL13RA1 and IL4R, respectively.^[1]^[2] These two genes encode the proteins IL-13Rα1 and IL-4Rα. These form a dimer with IL-13 binding to the IL-13Rα1 chain and IL-4Rα stabilises this interaction. This IL-13 receptor can also instigate IL-4 signalling. In both cases this occurs via activation of the Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway, resulting in phosphorylation of STAT6. Phosphorylated STAT6 dimerises and acts as a transcription factor activating many genes, such as eotaxin.^{[citation needed]}

There is also another receptor that can bind IL-13: IL-13Rα2 encoded by the IL13RA2 gene. This binds IL-13 with very high affinity (and can therefore sequester it) but does not allow IL-4 binding. It acts as a negative regulator of both IL-13 and IL-4, however the mechanism of this is still undetermined.^[3]

References

^ Murata T, Obiri NI, Puri RK (1998). "Structure of and signal transduction through interleukin-4 and interleukin-13 receptors (review)". Int. J. Mol. Med. 1 (3): 551–7. doi:10.3892/ijmm.1.3.551. PMID 9852261.
^ Chomarat P, Banchereau J (1998). "Interleukin-4 and interleukin-13: their similarities and discrepancies". Int. Rev. Immunol. 17 (1–4): 1–52. doi:10.3109/08830189809084486. PMID 9914942.
^ Seyfizadeh, N., Seyfizadeh, N., Babaloo, Z. (2014). "Interleukin-13 as an Important Mediator: A Review on its Roles in Some Human Diseases", Iranian Journal of Allergy, Asthma and Immunology, In Press.

External links

Receptors, Interleukin-13 at the US National Library of Medicine Medical Subject Headings (MeSH)

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English Journal

Targeting IgE production in mice and humans.

Wu LC1, Scheerens H2.
Current opinion in immunology.Curr Opin Immunol.2014 Aug 22;31C:8-15. doi: 10.1016/j.coi.2014.08.001. [Epub ahead of print]
Immunoglobulin E (IgE) is pathogenic in allergic diseases such as asthma, allergic rhinitis, atopic dermatitis, and food allergy. Recent studies using genetically modified IgE reporter mice indicate that the majority of serum IgE in mice is produced by short-lived IgE plasma cells, with minor contri
PMID 25156315

T cells redirected to interleukin-13Rα2 with interleukin-13 mutein--chimeric antigen receptors have anti-glioma activity but also recognize interleukin-13Rα1.

Krebs S1, Chow KK2, Yi Z1, Rodriguez-Cruz T1, Hegde M3, Gerken C1, Ahmed N4, Gottschalk S5.
Cytotherapy.Cytotherapy.2014 Aug;16(8):1121-31. doi: 10.1016/j.jcyt.2014.02.012. Epub 2014 May 16.
BACKGROUND AIMS: Outcomes for patients with glioblastoma remain poor despite aggressive multimodal therapy. Immunotherapy with genetically modified T cells expressing chimeric antigen receptors (CARs) targeting interleukin (IL) 13Rα2, human epidermal growth factor receptor 2, epidermal growth facto
PMID 24841514

Association between genes encoding components of the IL-4/IL-4 receptor pathway and dermatitis in children.

Hussein YM1, Shalaby SM2, Nassar A3, Alzahrani SS4, Alharbi AS4, Nouh M5.
Gene.Gene.2014 Jul 25;545(2):276-81. doi: 10.1016/j.gene.2014.04.024. Epub 2014 Apr 15.
OBJECTIVE: To determine whether IL-4, IL-4Rα and STAT6 polymorphisms are associated with susceptibility to dermatitis in Egyptian children.METHODS: We genotyped three groups of children, consisting of 106 atopic dermatitis (AD) children, 95 non-AD children, and 100 of healthy controls, for IL-4 (-5
PMID 24742632

Japanese Journal

IL-13及びβ2アドレナリン受容体遺伝子多型が気管支喘息患者の肺機能へ及ぼす影響

齊藤美帆,山内広平
岩手医学雑誌 66(5), 179-184, 2014-12-01
NAID 110009872190

Cysteinyl leukotriene receptor antagonist regulates allergic airway inflammation in an organ- and cytokine-specific manner

Kawano Tetsuya,Matsuse Hiroto,Tsuchida Tomoko,Fukahori Susumu,Fukushima Chizu,Nishino Tomoya,Kohno Shigeru
Medical Science Monitor 20, 297-302, 2014-02-22
… Cys-LT receptor antagonists (LTRAs) decrease allergic airway inflammation. … In contrast, Dex significantly decreased Th1 and Th2 cytokines in MLNs and also decreased them (except IL-13 and IL-2) in spleen. …
NAID 120005438870

Periostin in Allergic Inflammation

, , , , ,
Allergology International 63(2), 143-151, 2014
… After we found that periostin is a downstream molecule of interleukin (IL)-4 and IL-13, signature cytokines of type 2 immune responses, we showed that periostin is a component of subepithelial fibrosis in bronchial asthma, the first formal proof that periostin is involved in allergic inflammation. …
NAID 130004477217

「インターロイキン13受容体」

interleukin 4 receptor
Identifiers
Symbol	IL4R
Alt. symbols	IL4RA; CD124
Entrez	3566
HUGO	6015
OMIM	147781
RefSeq	NM_000418
UniProt	Q9H186
Other data
Locus	Chr. 16 p12.1-11.2

interleukin 13 receptor, alpha 2
Identifiers
Symbol	IL13RA2
Alt. symbols	IL-13R, IL13BP, CD213a2
Entrez	3598
HUGO	5975
OMIM	300130
RefSeq	NM_000640
UniProt	Q14627
Other data
Locus	Chr. X q13.1-q28

interleukin 13 receptor, alpha 1
Identifiers
Symbol	IL13RA1
Alt. symbols	IL-13Ra, NR4, CD213a1
Entrez	3597
HUGO	5974
OMIM	300119
RefSeq	NM_001560
UniProt	P78552
Other data
Locus	Chr. X q24

　　[★]

英: interleukin-13 receptor、IL-13 receptor
関: IL-13受容体、IL-13レセプター

「IL-13受容体」

　　[★]

英: IL-13 receptor
関: インターロイキン13受容体、IL-13レセプター

「IL-13レセプター」

　　[★]

英: IL-13 receptor
関: インターロイキン13受容体、IL-13受容体

「interleukin-13 receptor」

　　[★]

インターロイキン13受容体

関: IL-13 receptor

「I」

　　[★]

「IL」

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[pmid9852261-1] Murata T, Obiri NI, Puri RK (1998). "Structure of and signal transduction through interleukin-4 and interleukin-13 receptors (review)". Int. J. Mol. Med. 1 (3): 551–7. doi:10.3892/ijmm.1.3.551. PMID 9852261.

[pmid9914942-2] Chomarat P, Banchereau J (1998). "Interleukin-4 and interleukin-13: their similarities and discrepancies". Int. Rev. Immunol. 17 (1–4): 1–52. doi:10.3109/08830189809084486. PMID 9914942.

[3] Seyfizadeh, N., Seyfizadeh, N., Babaloo, Z. (2014). "Interleukin-13 as an Important Mediator: A Review on its Roles in Some Human Diseases", Iranian Journal of Allergy, Asthma and Immunology, In Press.

リンク元	「インターロイキン13受容体」「IL-13受容体」「IL-13レセプター」「interleukin-13 receptor」
関連記事	「I」「IL」

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IL-13 receptor