interleukin-13 receptor

インターロイキン13受容体

関

IL-13 receptor

WordNet

1. a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
2. any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system

PrepTutorEJDIC

1. =sense organ / 受信装置

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/22 21:33:57」(JST)

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interleukin 13 receptor, alpha 1
Identifiers
Symbol	IL13RA1
Alt. symbols	IL-13Ra, NR4, CD213a1
Entrez	3597
HUGO	5974
OMIM	300119
RefSeq	NM_001560
UniProt	P78552
Other data
Locus	Chr. X q24

interleukin 13 receptor, alpha 2
Identifiers
Symbol	IL13RA2
Alt. symbols	IL-13R, IL13BP, CD213a2
Entrez	3598
HUGO	5975
OMIM	300130
RefSeq	NM_000640
UniProt	Q14627
Other data
Locus	Chr. X q13.1-q28

interleukin 4 receptor
Identifiers
Symbol	IL4R
Alt. symbols	IL4RA; CD124
Entrez	3566
HUGO	6015
OMIM	147781
RefSeq	NM_000418
UniProt	Q9H186
Other data
Locus	Chr. 16 p12.1-11.2

The interleukin-13 receptor is a type I cytokine receptor, binding Interleukin-13. It consists of two subunits, encoded by IL13RA1 and IL4R, respectively. These two genes encode the proteins IL-13Rα1 and IL-4Rα. These form a dimer with IL-13 binding to the IL-13Rα1 chain and IL-4Rα stabilises this interaction. This IL-13 receptor can also instigate IL-4 signalling. In both cases this occurs via activation of the Janus kinase (JAK)/Signal Transducer and Activator of Transcription (STAT) pathway, resulting in phosphorylation of STAT6. Phosphorylated STAT6 dimerises and acts as a transcription factor activating many genes, such as eotaxin.

There is also another receptor that can bind IL-13: IL-13Rα2 encoded by the IL13RA2 gene. This binds IL-13 with very high affinity (and can therefore sequester it) but does not allow IL-4 binding. It acts as a negative regulator of both IL-13 and IL-4, however the mechanism of this is still undetermined.

References

External links

• Receptors, Interleukin-13 at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

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• 1. 悪性神経膠腫に対する実験的治療アプローチ experimental treatment approaches for malignant gliomas

English Journal

• The association of the cytoplasmic domains of interleukin 4 receptor alpha and interleukin 13 receptor alpha 2 regulates interleukin 4 signaling.

• Andrews AL, Nordgren IK, Campbell-Harding G, Holloway JW, Holgate ST, Davies DE, Tavassoli A.SourceFaculty of Medicine, University of Southampton, Southampton, SO16 6YD, UK.
• Molecular bioSystems.Mol Biosyst.2013 Dec 29;9(12):3009-14. doi: 10.1039/c3mb70298g. Epub 2013 Sep 20.
• Interleukin-4 (IL-4) and Interleukin-13 (IL-13), key cytokines in the pathogenesis of allergic inflammatory disease, mediate their effects via a receptor composed of IL-13Rα1 and IL-4Rα. A third (decoy) receptor called IL-13Rα2 regulates interleukin signaling through this receptor complex. We emp
• PMID 24056919

• T helper cytokines in dry eye disease.

• Pflugfelder SC, Corrales RM, de Paiva CS.SourceOcular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, 6565 Fannin NC205, Houston, TX 77030, USA. Electronic address: stevenp@bcm.edu.
• Experimental eye research.Exp Eye Res.2013 Dec;117:118-25. doi: 10.1016/j.exer.2013.08.013. Epub 2013 Sep 4.
• Dry eye is an inflammatory disease that results from activation of innate inflammatory pathways in resident ocular surface cells, as well as cytokines produced by recruited T helper (Th) cells. Cytokines produced by the infiltrating Th cells alter the normal cytokine balance on the ocular surface an
• PMID 24012834

• New agents for targeting of IL-13RA2 expressed in primary human and canine brain tumors.

• Debinski W, Dickinson P, Rossmeisl JH, Robertson J, Gibo DM.SourceThe Brain Tumor Center of Excellence, Thomas K. Hearn Brain Tumor Research Center, Departments of Neurosurgery, Radiation Oncology, Wake Forest School of Medicine, Winston-Salem, North Carolina, United States of America.
• PloS one.PLoS One.2013 Oct 16;8(10):e77719. doi: 10.1371/journal.pone.0077719.
• Interleukin 13 receptor alpha 2 (IL-13RA2) is over-expressed in a vast majority of human patients with high-grade astrocytomas like glioblastoma. Spontaneous astrocytomas in dogs resemble human disease and have been proposed as translational model system for investigation of novel therapeutic strate
• PMID 24147065

Japanese Journal

• Role of IL13RA2 in Sunitinib Resistance in Clear Cell Renal Cell Carcinoma.

• PLOS ONE 10(6), 2015-06-26
• NAID 120005674662

• 薬剤運搬に適した腫瘍標的化抗体のスクリーニング法と創薬シーズ開発

• YAKUGAKU ZASSHI 133(9), 931-938, 2013
• NAID 130003361992

• Interleukin-13 enhanced Ca[2+] oscillations in airway smooth muscle cells.

• Cytokine 57(1), 19-24, 2012-01
• NAID 120003726117

Related Links

• IL13RA1 interleukin 13 receptor, alpha 1 [ (human)]

The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding ...

• IL13RA2 interleukin 13 receptor, alpha 2 [Homo sapiens (human)]

The protein encoded by this gene is closely related to Il13RA1, a subuint of the interleukin 13 receptor complex. This protein binds IL13 with high affinity, but lacks cytoplasmic domain, and does not appear to function as a signal ...

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★リンクテーブル★

リンク元	「IL-13 receptor」「インターロイキン13受容体」
拡張検索	「interleukin-13 receptor alpha1 subunit」「interleukin-13 receptor alpha2 subunit」
関連記事	「interleukin」「interleukins」

「IL-13 receptor」

　　[★]

• インターロイキン13受容体、IL-13受容体、IL-13レセプター

関

interleukin-13 receptor

「インターロイキン13受容体」

　　[★]

英

interleukin-13 receptor、IL-13 receptor

関

IL-13受容体、IL-13レセプター

「interleukin-13 receptor alpha1 subunit」

　　[★]

• インターロイキン13受容体α1サブユニット

「interleukin-13 receptor alpha2 subunit」

　　[★]

• インターロイキン13受容体α2サブユニット

「interleukin」

　　[★] インターロイキン IL 　

「interleukins」

　　[★] インターロイキン IL