WordNet
- the 9th letter of the Roman alphabet (同)i
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- 『私は』私が
- iodineの化学記号
- =sense organ / 受信装置
- Illinois
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- 1. 抗酸菌易感染性を示すメンデル型遺伝性疾患：特異的な遺伝子異常 mendelian susceptibility to mycobacterial diseases specific defects
- 2. リウマチ性疾患におけるサイトカインネットワーク：治療の意味 cytokine networks in rheumatic diseases implications for therapy
- 3. リウマチ性疾患における生物学的製剤の概要 overview of biologic agents in the rheumatic diseases
- 4. 原発性免疫不全症の診断のためのフローサイトメトリー flow cytometry for the diagnosis of primary immunodeficiencies
- 5. 免疫系の臨床検査評価 laboratory evaluation of the immune system
English Journal
- Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance.
- Vielnascher RM1, Hainzl E, Leitner NR, Rammerstorfer M, Popp D, Witalisz A, Rom R, Karaghiosoff M, Kolbe T, Müller S, Rülicke T, Lassnig C, Strobl B, Müller M.Author information 1Institute of Animal Breeding and Genetics, University of Veterinary Medicine, Veterinärplatz 1, 1210, Vienna, Austria.AbstractTyrosine kinase 2 (TYK2) has a pivotal role in immunity to infection and tumor surveillance. It is associated with several cytokine receptor chains including type I interferon (IFN) receptor 1 (IFNAR1), interleukin- (IL-) 12 receptor beta 1 (IL-12Rb1) and IL-10R2. We have generated a mouse with a conditional Tyk2 null allele and proved integrity of the conditional Tyk2 locus. TYK2 was successfully removed by the use of ubiquitous and tissue-specific Cre-expressing mouse strains. Myeloid TYK2 was found to critically contribute to the defense against murine cytomegalovirus. Ubiquitous TYK2 ablation severely impaired tumor immunosurveillance, while deletion in myeloid, dendritic or T cells alone showed no effect. The conditional Tyk2 mouse strain will be instrumental to further dissect TYK2 functions in infection, inflammation and cancer.
- Transgenic research.Transgenic Res.2014 Apr 3. [Epub ahead of print]
- Tyrosine kinase 2 (TYK2) has a pivotal role in immunity to infection and tumor surveillance. It is associated with several cytokine receptor chains including type I interferon (IFN) receptor 1 (IFNAR1), interleukin- (IL-) 12 receptor beta 1 (IL-12Rb1) and IL-10R2. We have generated a mouse with a co
- PMID 24696087
- Interleukin-12 (IL-12), but not IL-23, induces the expression of IL-7 in microglia and macrophages: implications for multiple sclerosis.
- Jana M1, Mondal S, Jana A, Pahan K.Author information 1Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA.AbstractInterleukin-12 (IL-12) p70 and IL-23 are bioactive cytokines and their biological functions are becoming clear. Increased expression of IL-7 in the central nervous system as well as in peripheral immune cells is associated with multiple sclerosis and experimental allergic encephalomyelitis. Here, we describe the induction of IL-7 in primary mouse and human microglia, BV-2 microglial cells, mouse peritoneal macrophages and astrocytes by IL-12p70. Interestingly, IL-12 strongly induced the expression of IL-7 whereas IL-23 and other p40 family members remained weak inducers of IL-7 in these cell types. Consistently, IL-12, but not IL-23 and other p40 family members, induced IL-7 promoter-driven luciferase activity in microglial cells. Among various stimuli tested, IL-12 emerged as the most potent stimulus followed by bacterial lipopolysaccharide and HIV-1 gp120 in inducing the activation of IL-7 promoter in microglial cells. Furthermore, increase in IL-7 mRNA expression by over-expression of IL-12p35 subunit, but not p40 and IL-23 p19 subunit, confirm that p35, but not p40 and p19, is responsible for the induction of IL-7. Finally, by using primary microglia from IL-12 receptor β1-deficient (IL-12Rβ1(-/-) ) and IL-12Rβ2(-/-) mice, we demonstrate that IL-12 induces the expression of IL-7 in microglia and macrophages via both IL-12Rβ2 and IL-12Rβ1. These studies delineate a novel biological function of IL-12 that is absent in IL-23 and other p40 family members.
- Immunology.Immunology.2014 Apr;141(4):549-63. doi: 10.1111/imm.12214.
- Interleukin-12 (IL-12) p70 and IL-23 are bioactive cytokines and their biological functions are becoming clear. Increased expression of IL-7 in the central nervous system as well as in peripheral immune cells is associated with multiple sclerosis and experimental allergic encephalomyelitis. Here, we
- PMID 24224652
- Chemokine (C-X-C motif) ligand (CXCL)10 in autoimmune diseases.
- Antonelli A1, Ferrari SM2, Giuggioli D3, Ferrannini E4, Ferri C5, Fallahi P6.Author information 1Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, 56126 Pisa, Italy. Electronic address: alessandro.antonelli@med.unipi.it.2Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, 56126 Pisa, Italy. Electronic address: sm.ferrari@int.med.unipi.it.3Department of Medical, Surgical, Maternal, Pediatric and Adult Sciences, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41100 Modena, Italy. Electronic address: giuggioli.dilia@policlinico.mo.it.4Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, 56126 Pisa, Italy. Electronic address: ferranni@ifc.cnr.it.5Department of Medical, Surgical, Maternal, Pediatric and Adult Sciences, University of Modena and Reggio Emilia, Via del Pozzo, 71, 41100 Modena, Italy. Electronic address: clferri@unimore.it.6Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, 56126 Pisa, Italy. Electronic address: poupak@int.med.unipi.it.Abstract(C-X-C motif) ligand (CXCL)10 (CXCL10) belongs to the ELR(-) CXC subfamily chemokine. CXCL10 exerts its function through binding to chemokine (C-X-C motif) receptor 3 (CXCR3), a seven trans-membrane receptor coupled to G proteins. CXCL10 and its receptor, CXCR3, appear to contribute to the pathogenesis of many autoimmune diseases, organ specific (such as type 1 diabetes, autoimmune thyroiditis, Graves' disease and ophthalmopathy), or systemic (such as rheumatoid arthritis, psoriatic arthritis, systemic lupus erythematosus, mixed cryoglobulinemia, Sjögren syndrome, or systemic sclerosis). The secretion of CXCL10 by cluster of differentiation (CD)4+, CD8+, natural killer (NK) and NK-T cells is dependent on interferon (IFN)-γ, which is itself mediated by the interleukin-12 cytokine family. Under the influence of IFN-γ, CXCL10 is secreted by several cell types including endothelial cells, fibroblasts, keratinocytes, thyrocytes, preadipocytes, etc. Determination of high level of CXCL10 in peripheral fluids is therefore a marker of host immune response, especially T helper (Th)1 orientated T-cells. In tissues, recruited Th1 lymphocytes may be responsible for enhanced IFN-γ and tumor necrosis factor-α production, which in turn stimulates CXCL10 secretion from a variety of cells, therefore creating an amplification feedback loop, and perpetuating the autoimmune process. Further studies are needed to investigate interactions between chemokines and cytokines in the pathogenesis of autoimmune diseases and to evaluate whether CXCL10 is a novel therapeutic target in various autoimmune diseases.
- Autoimmunity reviews.Autoimmun Rev.2014 Mar;13(3):272-80. doi: 10.1016/j.autrev.2013.10.010. Epub 2013 Nov 2.
- (C-X-C motif) ligand (CXCL)10 (CXCL10) belongs to the ELR(-) CXC subfamily chemokine. CXCL10 exerts its function through binding to chemokine (C-X-C motif) receptor 3 (CXCR3), a seven trans-membrane receptor coupled to G proteins. CXCL10 and its receptor, CXCR3, appear to contribute to the pathogene
- PMID 24189283
Japanese Journal
- Liposomal Lipopolysaccharide Initiates TRIF-Dependent Signaling Pathway Independent of CD14.
- Watanabe Sachiko,Kumazawa Yoshio,Inoue Joe
- PloS one 8(4), 2013-04-02
- … Lipopolysaccharide (LPS) is recognized by CD14 with Toll-like receptor 4 (TLR4), and initiates 2 major pathways of TLR4 signaling, the MyD88-dependent and TRIF-dependent signaling pathways. … The MyD88-dependent pathway induces inflammatory responses such as the production of TNF-α, IL-6, and IL-12 via the activation of NFκB and MAPK. …
- NAID 120005244422
- Effects of Oral Administration of Probiotics from Mongolian Dairy Products on the Th1 Immune Response in Mice
- TAKEDA Shiro,KAWAHARA Satoshi,HIDAKA Muneaki,YOSHIDA Hiroki,WATANABE Wataru,TAKESHITA Masahiko,KIKUCHI Yukiharu,BUMBEIN Dashnyam,MUGURUMA Michio,KUROKAWA Masahiko
- Bioscience, Biotechnology, and Biochemistry 77(7), 1372-1378, 2013
- … Among these strains, the Lactobacillus plantarum 06CC2 strain was effective in elevating the level of interleukin (IL)-12p40 in co-culture with J774.1 cells and the levels of IL-12 and interferon (IFN)-γ in co-culture with mouse spleen cells in vitro. …
- NAID 130003361125
- Suppressive Effects of Oral Administration of Heat-Killed Lactobacillus acidophilus on T Helper-17 Immune Responses in a Bovine β-Lactoglobulin-Sensitized Mice Model
- Li Ai-li,Meng Xiang-chen,Duan Cui-cui,Huo Gui-cheng,Zheng Quan-ling,Li Dan
- Biological and Pharmaceutical Bulletin 36(2), 202-207, 2013
- … the levels of cytokine (interleukin (IL)-12, IL-4, tumor growth factor (TGF)-β, IL-10, IL-6 and IL-17A), total immunoglobulin E (IgE) and β-lg-specific IgE contents in the serum were measured with enzyme-linked immunosorbent assay (ELISA); …
- NAID 130002480760
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- Detailed information about IL-12 family, IL-12 functions, and antitumor roles. Sino biological offers a range of high-quality proteins and antibodies for research on IL-12 family ligands, IL-12 family receptors and IL-12 family signaling.
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★リンクテーブル★
| リンク元 | 「インターロイキン12受容体」「IL-12受容体」「IL-12レセプター」「interleukin-12 receptor」 |
| 関連記事 | 「I」「IL」 |
「インターロイキン12受容体」
「IL-12受容体」
「IL-12レセプター」
「interleukin-12 receptor」
「I」
「IL」