- 関
- IL11 receptor、interleukin-11 receptor
WordNet
- the 9th letter of the Roman alphabet (同)i
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- 『私は』私が
- iodineの化学記号
- =sense organ / 受信装置
- Illinois
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/03/22 09:06:02」(JST)
[Wiki en表示]
| interleukin 11 receptor, alpha |
| Identifiers |
| Symbol |
IL11RA |
| Entrez |
3590 |
| HUGO |
5967 |
| OMIM |
600939 |
| RefSeq |
NM_004512 |
| UniProt |
Q14626 |
| Other data |
| Locus |
Chr. 9 p13 |
| interleukin 11 receptor, beta |
| Identifiers |
| Symbol |
IL11RB |
| HUGO |
5968 |
The interleukin 11 receptor is a type I cytokine receptor, binding interleukin 11. It is a heterodimer composed of an interleukin 11 receptor alpha subunit and an incompletely characterized beta subunit.[1]
References
- ^ Chérel M, Sorel M, Lebeau B, Dubois S, Moreau JF, Bataille R, Minvielle S, Jacques Y (1995). "Molecular cloning of two isoforms of a receptor for the human hematopoietic cytokine interleukin-11". Blood. 86 (7): 2534–40. PMID 7670098.
External links
- Receptors, Interleukin-11 at the US National Library of Medicine Medical Subject Headings (MeSH)
|
Cytokine receptors
|
|
Chemokine receptor
(GPCRs) |
| CC |
- CCR1 / CCRL1
- CCR2
- CCRL2
- CCR3
- CCR4
- CCR5
- CCR6
- CCR7
- CCR8
- CCR9
- CCR10
|
|
| CXC |
- IL-8
- CXCR3
- CXCR4
- CXCR5
- CXCR6
- CXCR7
|
|
| Other |
|
|
|
| TNF receptor |
| 1-10 |
- TNFR1 (TNFRSF1A)
- TNFR2 (TNFRSF1B)
- LTBR (TNFRSF3)
- CD134 (TNFRSF4)
- CD40 (TNFRSF5)
- Fas receptor (TNFRSF6)
- DcR3 (TNFRSF6B)
- CD27 (TNFRSF7)
- CD30 (TNFRSF8)
- CD137 (TNFRSF9)
|
|
| 11-20 |
- DR4 (TNFRSF10A)
- DR5 (TNFRSF10B)
- DcR1 (TNFRSF10C)
- DcR2 (TNFRSF10D)
- RANK (TNFRSF11A)
- Osteoprotegerin (TNFRSF11B)
- TweakR (TNFRSF12A)
- TACI (TNFRSF13B)
- BAFFR (TNFRSF13C)
- HVEM (TNFRSF14)
- NGFR (TNFRSF16)
- BCMA (TNFRSF17)
- GITR (TNFRSF18)
- TAJ/TROY (TNFRSF19)
|
|
| 21-27 |
- DR6 (TNFRSF21)
- DR3 (TNFRSF25)
- EDA2R (TNFRSF27)
|
|
|
| JAK-STAT |
| Type I |
| γ-chain |
- Interleukin receptors
- IL2R / IL2RA/IL2RB / IL15R
- IL4R / IL13R / IL13RA1 / IL13RA2
- IL7R / IL7RA
- IL9R
- IL21R
|
|
| β-chain |
- Interleukin receptors
- IL3R / IL3RA
- IL5R / IL5RA
- GM-CSF
|
|
| gp130 |
- Interleukin receptors
- IL6RA
- 11/IL11RA
- 27/IL27RA
- OSMR
- LIFR
- CNTFR
|
|
| IL12RB1 |
- Interleukin receptors
- IL12R/IL12RB1/IL12RB2
- IL23R23
|
|
| Other |
- hormone receptor: GH
- prolactin
|
|
|
| Type II |
- Interleukin receptors
- IL10R / IL10RA / IL10RB / IL22R / IL22RA1 / IL22RA2
- IL20R / IL20RA / IL20RB
- IL28R
- Interferon receptors
- -α/β / IFNAR1/IFNAR2
- -γ/IFNGR1 / IFNGR2
|
|
|
| Ig superfamily |
- CSF1
- KIT
- IL1
- IL18R / IL18R1
|
|
| IL 17 family |
- IL17
- IL17RA
- IL17RB
- IL17RC
- IL17RD
- IL17RE
|
|
| S/T |
|
|
Interleukin receptor modulators
|
|
| IL-1 |
- Agonists: Interleukin 1 (α, β)
- Mobenakin
- Pifonakin
- Antagonists: AF-12198
- Anakinra
- IL-1RA
- Isunakinra
- Antibodies: Canakinumab
- Gevokizumab
- Lutikizumab
- Decoy receptors: Rilonacept (IL-1 Trap)
|
|
| IL-2 |
- Agonists: Adargileukin alfa
- Aldesleukin
- Celmoleukin
- Denileukin diftitox
- Interleukin 2
- Pegaldesleukin
- Teceleukin
- Tucotuzumab celmoleukin
- Antibodies: Basiliximab
- Daclizumab (dacliximab)
- Inolimomab
|
|
| IL-3 |
- Agonists: Daniplestim
- Interleukin 3
- Leridistim
- Milodistim
- Muplestim
- Promegapoietin
|
|
| IL-4 |
- Agonists: Binetrakin
- Interleukin 4
- Interleukin 13
- Antibodies: Dupilumab
- Pascolizumab
|
|
| IL-5 |
- Antibodies: Benralizumab
- Mepolizumab
- Reslizumab
- Antisense oligonucleotides: TPI ASM8
|
|
| IL-6 |
- Agonists: Atexakin alfa
- Interleukin 6
- Antibodies: ARGX-109
- Clazakizumab
- Elsilimomab
- mAb 1339
- Olokizumab
- Sarilumab
- Siltuximab
- Sirukumab
- Tocilizumab
|
|
| IL-7 |
|
|
| IL-8 |
- See CXCR1 (IL-8Rα) and CXCR2 (IL-8Rβ) here instead.
|
|
| IL-9 |
|
|
| IL-10 |
- Agonists: Ilodecakin
- Interleukin 10 (CSIF)
|
|
| IL-11 |
- Agonists: Interleukin 11 (AGIF)
- Oprelvekin
|
|
| IL-12 |
- Agonists: Edodekin alfa
- Interleukin 12
- Antibodies: Briakinumab
- Ustekinumab
|
|
| IL-13 |
- Agonists: Binetrakin
- Cintredekin besudotox
- Interleukin 4
- Interleukin 13
- Antibodies: Anrukinzumab
- Lebrikizumab
- Tralokinumab
|
|
| IL-15 |
- Agonists: ALT-803
- Interleukin 15
|
|
| IL-17 |
- Agonists: Interleukin 17 (A, B, C, D, E (interleukin 25), F)
- Antibodies: Brodalumab
- Ixekizumab
- Perakizumab
- Remtolumab
- Secukinumab
- Vunakizumab
|
|
| IL-18 |
- Agonists: Iboctadekin
- Interleukin 18
- Interleukin 37
- Tadekinig
|
|
| IL-20 |
- Agonists: Interleukin 19
- Interleukin 20
- Interleukin 24
- Antibodies: Fletikumab (against IL-20)
|
|
| IL-21 |
- Agonists: Denenicokin
- Interleukin 21
- Antibodies: NNC0114-0005
- NNC0114-0006
|
|
| IL-22 |
- Antibodies: Fezakinumab (against IL-22)
|
|
| IL-23 |
- Agonists: Interleukin 23 (SGRF)
- Antibodies: Brazikumab
- Briakinumab
- Guselkumab
- Tildrakizumab
- Ustekinumab
|
|
| IL-27 |
- Agonists: Interleukin 27 (interleukin 30)
|
|
| IL-28 |
- Agonists: Interferon λ4 (IFN-λ4)
- Interleukin 28 (A (IFN-λ2), B (IFN-λ3))
- Interleukin-29 (IFN-λ1)
|
|
| IL-31 |
|
|
| IL1RL1 |
|
|
| IL1RL2 |
- Agonists: Interleukin 36 (α, β, γ)
- Interleukin 38
|
|
| Others |
|
JAK
|
|
|
|
Others
|
- Interleukin 14 (taxilin alpha, HMW-BCGF)
- Interleukin 16 (signals through CD4)
- Interleukin 24 (signals through IL-22Rα1/IL-20Rβ heterodimer)
- Interleukin 26 (signals through IL-20Rα/IL-10Rβ heterodimer)
- Interleukin 32
- Interleukin 34 (signals through M-CSFR/CSF1R)
- Interleukin 35
|
|
|
- See also: Cytokine receptor modulators
- Peptide receptor modulators
|
UpToDate Contents
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English Journal
- Interleukin-11-driven gastric tumourigenesis is independent of trans-signalling.
- Balic JJ1, Garbers C2, Rose-John S2, Yu L1, Jenkins BJ3.
- Cytokine.Cytokine.2017 Feb 1;92:118-123. doi: 10.1016/j.cyto.2017.01.015. [Epub ahead of print]
- Deregulated gp130-dependent STAT3 signalling by the pleiotropic cytokine interleukin (IL)-11 has been implicated in the pathogenesis of gastric cancer (GC), the third most common cancer worldwide. While the IL-11-gp130-STAT3 signalling axis has traditionally been thought to exclusively use the membr
- PMID 28160627
- Interleukin-11 binds specific EF-hand proteins via their conserved structural motifs.
- Kazakov AS1, Sokolov AS1, Vologzhannikova AA1, Permyakova ME1, Khorn PA1, Ismailov RG1, Denessiouk KA2, Denesyuk AI1,2, Rastrygina VA1, Baksheeva VE3, Zernii EY3, Zinchenko DV4, Glazatov VV5, Uversky VN1,6, Mirzabekov TA7,8, Permyakov EA1, Permyakov SE1.
- Journal of biomolecular structure & dynamics.J Biomol Struct Dyn.2017 Jan;35(1):78-91. doi: 10.1080/07391102.2015.1132392. Epub 2016 Mar 8.
- Interleukin-11 (IL-11) is a hematopoietic cytokine engaged in numerous biological processes and validated as a target for treatment of various cancers. IL-11 contains intrinsically disordered regions that might recognize multiple targets. Recently we found that aside from IL-11RA and gp130 receptors
- PMID 26726132
- Expression, Purification, and Characterization of Interleukin-11 Orthologues.
- Sokolov AS1, Kazakov AS2, Solovyev VV3, Ismailov RG4, Uversky VN5,6, Lapteva YS7, Mikhailov RV8, Pavlova EV9, Terletskaya IO10, Ermolina LV11, Permyakov SE12, Permyakov EA13.
- Molecules (Basel, Switzerland).Molecules.2016 Nov 29;21(12). pii: E1632.
- Interleukin-11 (IL-11) is a multifunctional cytokine implicated in several normal and pathological processes. The decoding of IL-11 function and development of IL-11-targeted drugs dictate the use of laboratory animals and need of the better understanding of species specificity of IL-11 signaling. H
- PMID 27916836
Japanese Journal
- Regulation of osteoblast differentiation by interleukin-11 via AP-1 and Smad signaling
- Compressive Force Induces the Expression of Bone Remodeling-Related Proteins via Interleukin-11 Production in MC3T3-E1 Cells
- IL-1<i>β</i>およびTNF-<i>α</i>刺激ヒト顎関節滑膜細胞におけるIL-6 cytokine familyの発現
★リンクテーブル★
[★]
- 英
- interleukin-11 receptor、IL-11 receptor
- 関
- インターロイキン11レセプター、IL-11受容体、IL-11レセプター
[★]
- 関
- IL-11 receptor、IL11 receptor
[★]
- 英
- IL-11 receptor
- 関
- インターロイキン11受容体、IL-11レセプター
[★]
- 英
- IL-11 receptor
- 関
- インターロイキン11受容体、IL-11受容体
[★]
[★]