アディー症候群。ホームズ・アディー症候群
WordNet
- English geologist and supporter of the theory of continental drift (1890-1965) (同)Arthur Holmes
- United States writer of humorous essays (1809-1894) (同)Oliver Wendell Holmes
- United States jurist noted for his liberal opinions (1841-1935) (同)Oliver Wendell Holmes Jr.
- a pattern of symptoms indicative of some disease
- a complex of concurrent things; "every word has a syndrome of meanings"
PrepTutorEJDIC
- ホームズ(Oliver Wendell~;1809‐94;米国の詩人・小説家) / (Sherlock~; 1 シャーロックホームズ 《Conan Doyle 作の推理小説中の主人公で名探偵》
- (疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/27 12:06:55」(JST)
[Wiki en表示]
| Adie's syndrome |
| Classification and external resources |
Two-sided dilated pupils given the observational diagnosis Adie's pupils by an ophthalmologist |
| ICD-10 |
H57.0 |
| ICD-9 |
379.46 |
| DiseasesDB |
29742 |
| MeSH |
D015845 |
Adie syndrome, sometimes known as Holmes-Adie Syndrome or Adie's Tonic Pupil, is a neurological disorder characterized by a tonically dilated pupil.[1] It is named after the British neurologist William John Adie. It is caused by damage to the postganglionic fibers of the parasympathetic innervation of the eye, usually by a viral or bacterial infection which causes inflammation, and affects the pupil of the eye and the autonomic nervous system. [1]
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Contents
- 1 Signs and symptoms
- 2 Causes
- 3 Diagnosis
- 4 Treatment
- 5 Prognosis
- 6 Epidemiology
- 7 See also
- 8 References
- 9 External links
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Signs and symptoms
Adie syndrome presents with three hallmark symptoms, namely at least one abnormally dilated pupil (mydriasis) which does not constrict in response to light, loss of deep tendon reflexes and diaphoresis (excessive sweating).[1] Other signs may include hyperopia due to accommodative paresis, photophobia and difficulty reading.[2]
Causes
Pupillary symptoms of Holmes-Adie Syndrome are thought to be the result of a viral or bacterial infection that causes inflammation and damage to neurons in the ciliary ganglion, an area of the brain that provides parasympathetic control of eye constriction. Additionally, patients with Holmes-Adie Syndrome can also experience problems with autonomic control of the body. This second set of symptoms is caused by damage to the dorsal root ganglia of the spinal cord.[1]
Diagnosis
Clinical exam may reveal sectoral paresis of the iris sphincter or vermiform iris movements. The tonic pupil may become smaller (miotic) over time which is referred to as "little old Adie's".[3] Testing with low dose (1/8%) pilocarpine may constrict the tonic pupil due to cholinergic denervation supersensitivity.[1] A normal pupil will not constrict with the dilute dose of pilocarpine.[3] CT scans and MRI scans may be useful in the diagnostic testing of focal hypoactive reflexes.[4]
Treatment
The usual treatment of a standardised Adie syndrome is to prescribe reading glasses to correct for impairment of the eye(s).[1] Pilocarpine drops may be administered as a treatment as well as a diagnostic measure.[1] Thoracic sympathectomy is the definitive treatment of diaphoresis, if the condition is not treatable by drug therapy.[1]
Prognosis
Adie's syndrome is not life threatening or disabling.[1] As such, there is no mortality rate relating to the condition; however, loss of deep tendon reflexes is permanent and may progress over time.[1]
Epidemiology
It most commonly affects younger women (2.6:1 female preponderance) and is unilateral in 80% of cases.[3] Average age of onset is 32 years.
See also
- Ross’ syndrome
- Ciliary ganglion
References
- ^ a b c d e f g h i j National Institute of Neurological Disorders and Stroke. "Holmes-Adie syndrome Information Page". http://www.ninds.nih.gov/disorders/holmes_adie/holmes_adie.htm. Retrieved 2008-01-21.
- ^ Stedman's Medical Dictionary, 27th Edition. 2000. ISBN 0-683-40007-X.
- ^ a b c Haines, Duane E. (2002). Fundamental Neuroscience, 2nd edition. ISBN 0-443-06603-5.
- ^ "Diagnosis of Adie syndrome". WrongDiagnosis.com. http://www.wrongdiagnosis.com/a/adie_syndrome/diagnosis.htm. Retrieved 2008-01-21.
External links
- Personal experience
- Animation at mrcophth.com
UpToDate Contents
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English Journal
- Teaching video neuroimages: acute Adie syndrome.
- Wakerley BR, Tan MH, Turner MR.SourceDepartment of Neurology, John Radcliffe Hospital, Oxford, UK.
- Neurology.Neurology.2012 Sep 11;79(11):e97. doi: 10.1212/WNL.0b013e3182698cc5.
- PMID 22965679
- Durán-Ferreras E, Idígoras-Hurtado A, Caballero-Granado J.SourceUnidad de Neurología, Hospital Infanta Elena, Huelva, España. eduardoduranferreras@gmail.com
- Medicina clínica.Med Clin (Barc).2012 May 26;138(15):e29. doi: 10.1016/j.medcli.2011.09.010. Epub 2011 Oct 28.
- PMID 22036461
Japanese Journal
- Idiopathic Unilateral Hyperhidrosis with Holmes-Adie Syndrome : Case Report
- COSKUN Basak Kandi,SARAL Yunus,BELIRGEN Sait,OZTURK Perihan
- Journal of dermatology 31(6), 473-476, 2004-06-01
- NAID 50000516136
- Orthostatic hypotension and Holmes-Adie syndrome. Usefulness of the Valsalva ratio in the evalution of baroreceptor dysfunction
Related Links
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- Holmes-Adie's syndrome, sometimes known as Adie's syndrome or Adie's Tonic Pupil, is a neurological disorder which affects the pupil of the eye and the autonomic nervous system. It is named after the British neurologist William ...
★リンクテーブル★
[★]
- 英
- Adie's syndrome, Adie syndrome
- 同
- Adie症候群、ホームズ・アディー症候群 Holmes-Adie syndrome、アディー徴候
- 関
- アディー瞳孔
[★]
- 関
- adenoviral、adenovirus
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