アディー症候群
WordNet
- a pattern of symptoms indicative of some disease
- a complex of concurrent things; "every word has a syndrome of meanings"
PrepTutorEJDIC
- (疾患の徴候となる一群の)症徴候,症候群 / (事件・社会的状態などのパターンを示す)徴候形態
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/05 06:49:20」(JST)
[Wiki en表示]
| Adie's syndrome |
|
Bilateral mydriasis given the observational diagnosis Adie's pupils by an ophthalmologist
|
| Classification and external resources |
| Specialty |
ophthalmology |
| ICD-10 |
H57.0 |
| ICD-9-CM |
379.46 |
| DiseasesDB |
29742 |
| MeSH |
D015845 |
|
[edit on Wikidata]
|
Adie syndrome (), sometimes known as Holmes–Adie syndrome or Adie's tonic pupil, is a neurological disorder characterized by a tonically dilated pupil that reacts slowly to light but shows a more definite response to accommodation (i.e., light-near dissociation).[1] It is frequently seen in females with absent knee or ankle jerks and impaired sweating. It is named after the British neurologist William John Adie. It is caused by damage to the postganglionic fibers of the parasympathetic innervation of the eye, usually by a viral or bacterial infection which causes inflammation, and affects the pupil of the eye and the autonomic nervous system.[1]
Contents
- 1 Signs and symptoms
- 2 Pathophysiology
- 3 Diagnosis
- 4 Treatment
- 5 Prognosis
- 6 Epidemiology
- 7 See also
- 8 References
- 9 External links
Signs and symptoms
Adie syndrome presents with three hallmark symptoms, namely at least one abnormally dilated pupil (mydriasis) which does not constrict in response to light, loss of deep tendon reflexes, and abnormalities of sweating.[1] Other signs may include hyperopia due to accommodative paresis, photophobia and difficulty reading.[2]
Pathophysiology
Pupillary symptoms of Holmes–Adie syndrome are thought to be the result of a viral or bacterial infection that causes inflammation and damage to neurons in the ciliary ganglion, located in the posterior orbit, that provides parasympathetic control of eye constriction. Additionally, patients with Holmes-Adie Syndrome can also experience problems with autonomic control of the body. This second set of symptoms is caused by damage to the dorsal root ganglia of the spinal cord.[1]
Diagnosis
Clinical exam may reveal sectoral paresis of the iris sphincter or vermiform iris movements. The tonic pupil may become smaller (miotic) over time which is referred to as "little old Adie's".[3] Testing with low dose (1/8%) pilocarpine may constrict the tonic pupil due to cholinergic denervation supersensitivity.[1] A normal pupil will not constrict with the dilute dose of pilocarpine.[3] CT scans and MRI scans may be useful in the diagnostic testing of focal hypoactive reflexes.[4]
Treatment
The usual treatment of a standardised Adie syndrome is to prescribe reading glasses to correct for impairment of the eye(s).[1] Pilocarpine drops may be administered as a treatment as well as a diagnostic measure.[1] Thoracic sympathectomy is the definitive treatment of diaphoresis, if the condition is not treatable by drug therapy.[1]
Prognosis
Adie's syndrome is not life-threatening or disabling.[1] As such, there is no mortality rate relating to the condition; however, loss of deep tendon reflexes is permanent and may progress over time.[1]
Epidemiology
It most commonly affects younger women (2.6:1 female preponderance) and is unilateral in 80% of cases.[3] Average age of onset is 32 years.
See also
- Ross’ syndrome
- Ciliary ganglion
References
- ^ a b c d e f g h i j National Institute of Neurological Disorders and Stroke. "Holmes-Adie syndrome Information Page". Retrieved 2008-01-21.
- ^ Stedman's Medical Dictionary, 27th Edition. 2000. ISBN 0-683-40007-X.
- ^ a b c Haines, Duane E. (2002). Fundamental Neuroscience, 2nd edition. ISBN 0-443-06603-5.
- ^ "Diagnosis of Adie syndrome". WrongDiagnosis.com. Retrieved 2008-01-21.
External links
- Animation at mrcophth.com
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- A Rare Case in the Emergency Department: Holmes-Adie Syndrome.
- Colak S1, Erdogan MO1, Senel A1, Kibici O1, Karaboga T1, Afacan MA1, Akdemir HU1.
- Turkish journal of emergency medicine.Turk J Emerg Med.2016 Mar 2;15(1):40-2. doi: 10.5505/1304.7361.2015.59144. eCollection 2015.
- Holmes-Adie syndrome (HAS) is a rare syndrome characterized by tonic pupil and the absence of deep tendon reflexes. HAS was first described in 1931 and is usually idiopathic, with incidences reported to be 4-7 per 100,000. Although tonic pupil is usually unilateral, it can also be bilateral. Enlarge
- PMID 27437522
- Ross Syndrome: A Case Report and Review of Cases from India.
- Agarwala MK1, George L1, Parmar H2, Mathew V3.
- Indian journal of dermatology.Indian J Dermatol.2016 May-Jun;61(3):348. doi: 10.4103/0019-5154.182472.
- Ross syndrome is a rare dysautonomia characterized by a clinical complex of segmental anhidrosis or hypohidrosis, areflexia, and tonic pupils. A very few cases (≃50) have been reported in literature since its original description in 1958. Here, we report the case of a middle-aged homemaker from Od
- PMID 27293279
- Harlequin syndrome: a mask of rare dysautonomic syndromes.
- Kaur S1, Aggarwal P, Jindal N, Dayal S, Jairath V, Jain VK, Virdi S.
- Dermatology online journal.Dermatol Online J.2015 Apr 16;21(4). pii: 13030/qt3q39d7mz.
- Harlequin syndrome (HS) is a rare disorder of the sympathetic nervous system which presents with unilateral decreased sweating and flushing of the face, neck, and chest in response to heat, exercise, or emotional factors. The contralateral side displays a compensatory overreaction to provide normal
- PMID 25933078
Japanese Journal
- Harlequin 症候群と Adie 症候群を呈した Ross syndrome plus
Related Pictures
★リンクテーブル★
[★]
- 英
- Adie's syndrome, Adie syndrome
- 同
- Adie症候群、ホームズ・アディー症候群 Holmes-Adie syndrome、アディー徴候
- 関
- アディー瞳孔
[★]
アディー症候群。ホームズ・アディー症候群
[★]
- 関
- adenoviral、adenovirus
[★]