WordNet

PrepTutorEJDIC

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. HIV抗レトロウイルス療法に関する臨床試験：インテグラーゼ阻害剤 clinical trials of hiv antiretroviral therapy integrase inhibitors
2. HIV-2感染の治療 treatment of hiv 2 infection
3. HIV薬剤耐性検査アッセイの概要 overview of hiv drug resistance testing assays
4. HIV感染患者における日和見感染症の一次予防の概要 overview of primary prevention of opportunistic infections in hiv infected patients
5. 急性期および早期のHIV感染：治療 acute and early hiv infection treatment

Guo DL, Zhang XJ, Wang RR, Zhou Y, Li Z, Xu JY, Chen KX, Zheng YT, Liu H.SourceState Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, PR China; Department of Medicinal Chemistry, China Pharmaceutical University, 24 TongjiaXiang, Nanjing, PR China.
Bioorganic & medicinal chemistry letters.Bioorg Med Chem Lett.2012 Dec 1;22(23):7114-8. doi: 10.1016/j.bmcl.2012.09.070. Epub 2012 Oct 2.
A series of 5,6-dihydroxypyrimidine analogs were synthesized and evaluated for their anti-HIV activity in vitro. Among all of the analogs, several compounds exhibited significant anti-HIV activity, especially 1b and 1e, which showed the most potent anti-HIV activity with EC(50) values of 0.14 and 0.
PMID 23099098

Geretti AM, Armenia D, Ceccherini-Silberstein F.SourceaInstitute of Infection and Global Health, University of Liverpool, Liverpool, UK bDepartment of Experimental Medicine and Surgery, University of Rome Tor Vergata, Italy.
Current opinion in infectious diseases.Curr Opin Infect Dis.2012 Dec;25(6):677-86. doi: 10.1097/QCO.0b013e32835a1de7.
PURPOSE OF REVIEW: This review highlights recent data on the pathways of resistance that impact the clinical activity of first-generation and second-generation integrase inhibitors.RECENT FINDINGS: Raltegravir (RAL) and elvitegravir (EVG) are highly efficacious in first-line antiretroviral therapy,
PMID 23086187

Use of a Hexasubstituted Benzene Scaffold in the Development of Multivalent HIV-1 Integrase Inhibitors

Use of a Hexasubstituted Benzene Scaffold in the Development of Multivalent HIV-1 Integrase Inhibitors

, , , ,
Chemical and Pharmaceutical Bulletin 62(8), 754-763, 2014
… The highly directional hexasubstituted benzene moiety was used as the central scaffold to create new human immunodeficiency virus (HIV)-1 integrase inhibitors through the attachment of multiple active groups. …
NAID 130004677382

Dialysis Purification of Integrase-DNA Complexes Provides High-Resolution Atomic Force Microscopy Images: Dimeric Recombinant HIV-1 Integrase Binding and Specific Looping on DNA.

Tsuruyama Tatsuaki,Nakai Tonau,Ohmori Rei,Ozeki Munetaka,Tamaki Keiji,Yoshikawa Kenichi
PloS one 8(1), 2013-01-14
… It remains difficult to obtain high-resolution atomic force microscopy images of HIV-1 integrase bound to DNA in a dimeric or tetrameric fashion. … We therefore constructed specific target DNAs to assess HIV-1 integrase binding and purified the complex by dialysis prior to analysis. …
NAID 120005241337