- 関
- high-density lipoprotein receptor
WordNet
- the 8th letter of the Roman alphabet (同)h
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- hydrogenの化学記号
- 鉛筆の硬度 / 《俗》heroin
- =sense organ / 受信装置
UpToDate Contents
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English Journal
- Developmental abnormalities in mouse embryos lacking the HDL receptor SR-BI.
- Santander NG, Contreras-Duarte S, Awad MF, Lizama C, Passalacqua I, Rigotti A, Busso D.AbstractThe srbi gene encodes a lipoprotein receptor with high affinity for high density lipoprotein that is mainly expressed in the liver and in steroidogenic tissues. Disruption of this gene in mice and mutations in humans lead to alterations in lipoprotein metabolism and/or fertility. During murine development, scavenger receptor class B member I (SR-BI) is present in the yolk sac and the placenta and is only expressed in the embryo itself late in gestation. In humans, it has been detected in trophoblast cells and placenta. Although the proportion of mice carrying a null mutation in SR-BI obtained from heterozygous intercrosses is lower than the expected by the Mendelian ratio, suggesting the involvement of this receptor in intrauterine development, the cause of this demise has remained unknown. In this work, we show that embryos lacking SR-BI exhibit a high prevalence of exencephaly with a sex bias toward females. Immunolocalization studies confirmed that SR-BI is not expressed in the embryo at early stages of development and allowed a more detailed description of its localization in the cells that mediate maternal-fetal transport of nutrients. SR-BI-null embryos contain less cholesterol than their wild-type littermates, suggesting the involvement of SR-BI in materno-fetal cholesterol transport. Newborn SR-BI-deficient pups exhibit intrauterine growth restriction, suggesting that this receptor is also important for fetal growth. Altogether, the results of our work suggest that the presence of SR-BI in extraembryonic tissues is involved in the maternal-fetal transport of cholesterol and/or other lipids with a role during neural tube closure and fetal growth.
- Human molecular genetics.Hum Mol Genet.2013 Mar 15;22(6):1086-96. doi: 10.1093/hmg/dds510. Epub 2012 Dec 5.
- The srbi gene encodes a lipoprotein receptor with high affinity for high density lipoprotein that is mainly expressed in the liver and in steroidogenic tissues. Disruption of this gene in mice and mutations in humans lead to alterations in lipoprotein metabolism and/or fertility. During murine deve
- PMID 23221804
- Biomimetic, synthetic HDL nanostructures for lymphoma.
- Yang S, Damiano MG, Zhang H, Tripathy S, Luthi AJ, Rink JS, Ugolkov AV, T K Singh A, Dave SS, Gordon LI, Thaxton CS.SourceDepartment of Medicine, Division of Hematology/Oncology, Northwestern University Feinberg School of Medicine, Chicago, IL 60611.
- Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2013 Feb 12;110(7):2511-6. doi: 10.1073/pnas.1213657110. Epub 2013 Jan 23.
- New therapies that challenge existing paradigms are needed for the treatment of cancer. We report a nanoparticle-enabled therapeutic approach to B-cell lymphoma using synthetic high density lipoprotein nanoparticles (HDL-NPs). HDL-NPs are synthesized using a gold nanoparticle template to control con
- PMID 23345442
Japanese Journal
- 終末糖化産物受容体(soluble receptor for advanced glycation endproducts: sRAGE)のメタボリック症候群におけるバイオマーカーとしての意義-アディポネクチンとの比較
- 守屋 里織,山崎 昌子,村上 博彦,丸山 健二,赫 洋美,内山 真一郎
- 東京女子医科大学雑誌 84(E1), E135-E140, 2014-01-31
- … AGE)の受容体であるReceptor for AGE(RAGE)は様々な細胞表面に存在しており、AGEと結合することにより動脈硬化を促進することが知られている。 … ,HMWRはBMI、ウエスト周囲径、収縮期血圧、拡張期血圧、尿酸、中性脂肪、白血球数、高感度CRPと負の相関が見られ、HDLコレステロールとは正の相関がみられた。 …
- NAID 110009752567
- Vitamin A-enriched Diet Modulates Reverse Cholesterol Transport in Hypercholesterolemic Obese Rats of the WNIN/Ob Strain
- Prashanth Anamthathmakula,Jeyakumar Shanmugam M,Giridharan Nappan V,Vajreswari Ayyalasomayajula
- Journal of Atherosclerosis and Thrombosis, 2014
- … Previously, we reported that chronic vitamin A feeding (129 mg/kg) for two months normalized the abnormally high plasma HDL-cholesterol (HDL-C) levels in hypercholesterolemic obese rats by upregulating the hepatic scavenger receptor class B type 1 (SR-BI) expression. …
- NAID 130004677971
- Circulating TNF Receptor 2 is Closely Associated with the Kidney Function in Non-Diabetic Japanese Subjects
- Kurashina Tomoyuki,Nagasaka Shoichiro,Watanabe Naoya,Yabe Daisuke,Sugi Noriko,Nin Kazuko,Hosokawa Masaya,Nomura Yoshio,Fukushima Mitsuo,Nakai Yoshikatsu,Nishimura Fusanori,Taniguchi Ataru
- Journal of Atherosclerosis and Thrombosis 21(7), 730-738, 2014
- … It is unclear whether an increased TNF system activity is present before the development of apparent CKD.Methods: Four hundred and twenty non-diabetic Japanese subjects with an estimated GFR (eGFR) greater than 60 ml/min/1.73 m2 were recruited for measurement of the HbA1c, insulin, TNF system activity (TNF-α, soluble TNF receptor 1 (sTNF-R1) and sTNF-R2) levels and various parameters, including the lipid, high-sensitivity C-reactive protein (hsCRP), high-molecular-weight (HMW) adiponectin and leptin levels. …
- NAID 130004677960
Related Links
- HDL transports cholesterol mostly to the liver or steroidogenic organs such as adrenals, ovary, and testes by direct and indirect pathways. HDL is removed by HDL receptors such as scavenger receptor BI (SR-BI), which mediate the selective ...
- SR-B1（scavenger receptor class B type 1）は、スカベンジャー受容体のひとつで、 遺伝子が同定されている。 SR-B1（SRB-1）は、HDL受容体として機能して、肝臓や 副腎で、HDLなどのリポ蛋白から、コレステロールエステルを細胞内に運ぶ働きをして いると、 ...
★リンクテーブル★
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- 英
- high-density lipoprotein receptor、HDL receptor
- 関
- 高密度リポ蛋白受容体、高密度リポ蛋白レセプター、高密度リポタンパク質レセプター、HDLレセプター、HDL受容体
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- 英
- high-density lipoprotein receptor、HDL receptor
- 関
- 高密度リポタンパク質受容体、高密度リポ蛋白受容体、高密度リポ蛋白レセプター、HDLレセプター、HDL受容体
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- 関
- HDL receptor
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- 英
- HDL receptor
- 関
- 高密度リ・タンパク質受容体、高密度リ・タンパク質レセプター、HDLレセプター
[★]
- 英
- HDL receptor
- 関
- 高密度リ・タンパク質受容体、高密度リ・タンパク質レセプター、HDL受容体
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高比重リポ蛋白 high-density lipoprotein high density lipoprotein
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