移植片対宿主反応 GVH反応 graft-versus-host reaction

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1. 急性移植片対宿主病の臨床症状、診断、および重症度分類 clinical manifestations diagnosis and grading of acute graft versus host disease
2. 急性移植片対宿主病の治療 treatment of acute graft versus host disease
3. 慢性移植片対宿主病の臨床症状、診断、および重症度分類 clinical manifestations diagnosis and grading of chronic graft versus host disease
4. 移植片対宿主病の予防および治療に使用される免疫抑制剤の概要 overview of immunosuppressive agents used for prevention and treatment of graft versus host disease
5. 移植片対宿主病（GVHD）の皮膚症状 cutaneous manifestations of graft versus host disease gvhd

English Journal

Fetal microchimeric cells in autoimmune thyroid diseases: harmful, beneficial or innocent for the thyroid gland?

Lepez T, Vandewoestyne M, Deforce D.AbstractAutoimmune thyroid diseases (AITD) show a female predominance, with an increased incidence in the years following parturition. Fetal microchimerism has been suggested to play a role in the pathogenesis of AITD. However, only the presence of fetal microchimeric cells in blood and in the thyroid gland of these patients has been proven, but not an actual active role in AITD. Is fetal microchimerism harmful for the thyroid gland by initiating a Graft versus Host reaction (GvHR) or being the target of a Host versus Graft reaction (HvGR)? Is fetal microchimerism beneficial for the thyroid gland by being a part of tissue repair or are fetal cells just innocent bystanders in the process of autoimmunity? This review explores every hypothesis concerning the role of fetal microchimerism in AITD.
Chimerism.Chimerism.2013 Oct 1;4(4):111-118. Epub 2013 May 20.
Autoimmune thyroid diseases (AITD) show a female predominance, with an increased incidence in the years following parturition. Fetal microchimerism has been suggested to play a role in the pathogenesis of AITD. However, only the presence of fetal microchimeric cells in blood and in the thyroid gland
PMID 23723083

Toxic Epidermal Necrolysis and Graft-versus-Host Reaction: Revisiting a Puzzling Similarity.

Piérard GE1, Hermanns-Lê T, Paquet P, Rousseau AF, Delvenne P, Piérard-Franchimont C.Author information 1Laboratory of Skin Bioengineering and Imaging (LABIC), Department of Clinical Sciences, University of Liège, 4000 Liège, Belgium ; University of Franche-Comté, 25030 Besançon, France.AbstractDrug-induced toxic epidermal necrolysis (TEN) and acute cutaneous graft-versus-host reaction (GVHR) under immunopreventive therapy share some histopathological resemblance. So far, there are no serum biomarkers and no immunohistochemical criteria distinguishing with confidence and specificity the skin lesions of TEN and GVHR. Both diseases present as an inflammatory cell-poor necrotic reaction of the epidermis. This report compares three sets of 15 immunostaining patterns found in TEN, GVHR, and partial thickness thermal burns (PTTB), respectively. Three series of 17 skin biopsies were scrutinized. Irrespective of the distinct causal pathobiology of TEN and GVHR, similar secondary effector cells were recruited in lesional skin. Burns were less enriched in cells of the monocyte-macrophage disease. These cells likely exert deleterious effects in TEN and GVHR and cannot be simply regarded as passive bystanders. These life-threatening conditions are probably nursed, at least in part, by macrophages.
ISRN dermatology.ISRN Dermatol.2013 Jun 3;2013:651590. doi: 10.1155/2013/651590. Print 2013.
Drug-induced toxic epidermal necrolysis (TEN) and acute cutaneous graft-versus-host reaction (GVHR) under immunopreventive therapy share some histopathological resemblance. So far, there are no serum biomarkers and no immunohistochemical criteria distinguishing with confidence and specificity the sk
PMID 23862070

[Efficacy of donor lymphocyte infusion in patients after different types of allogeneic hematopoietic stem cell transplantation].

Slesarchuk OA, Babenko EV, Semenova EV, Bondarenko SN, Éstrina MA, Morozova EV, Paina OV, Vavilov VN, Smirnov BI, Zubarovskaia LS, Afanas'ev BV.AbstractAIM: To evaluate the efficacy of donor lymphocyte infusion (DLI) to prevent and treat recurrences in patients after different types of allogeneic hematopoietic stem cell transplantation (allo-HSCT).
Terapevticheskiĭ arkhiv.Ter Arkh.2013;85(7):26-33.
AIM: To evaluate the efficacy of donor lymphocyte infusion (DLI) to prevent and treat recurrences in patients after different types of allogeneic hematopoietic stem cell transplantation (allo-HSCT).SUBJECTS AND METHODS: Data from 118 patients with malignant blood diseases were analyzed. Allo-HSCTs f
PMID 24137944

Japanese Journal

DP-064-5 胸腺移植を併用した骨髄内骨髄移植 : GVHR予防とGVT増強効果(第107回日本外科学会定期学術集会)

三宅岳,保坂直樹,岡崎智,上山泰男,池原進
日本外科学会雑誌 108(臨時増刊号_2), 455, 2007-03-10
NAID 110006331826

NK細胞によるGVLRの増強とGVHRの抑制

田中淳司
臨床免疫 44(5), 521-529, 2005-11
NAID 40007043907

Unexpected role of TNF-α in graft versus host reaction (GVHR) : donor-derived TNF-α suppresses GVHR via inhibition of IFN-γ-dependent donor type-1 immunity

YAMAMOTO Satoshi,TSUJI Takemasa,MATSUZAKI Junko,ZHANGE Yue,CHAMOTO Kenji,KOSAKA Akemi,TOGASHI Yuji,SEKIKAWA Kenji,SAWADA Ken-ichi,TAKESHIMA Tsuguhide,KOIKE Takao,NISHIMURA Takashi
International immunology 16(6), 811-817, 2004-06-01
NAID 10013085923

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