フソバクテリウム・ヌクレアタム、フゾバクテリウム・ヌクレアタム
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- F. nucleatum
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/07/21 01:32:38」(JST)
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Fusobacterium nucleatum |
Scientific classification |
Domain: |
Bacteria |
Phylum: |
Fusobacteria |
Order: |
Fusobacteriales |
Family: |
Fusobacteriaceae |
Genus: |
Fusobacterium |
Species: |
F. nucleatum |
Fusobacterium nucleatum is an oral bacterium, indigenous to the human oral cavity, that plays a role in periodontal disease. This organism is commonly recovered from different monomicrobial and mixed infections in humans and animals. It is a key component of periodontal plaque due to its abundance and its ability to coaggregate with other species in the oral cavity.[1][2]
See also: Chronic periodontitis
Contents
- 1 Preterm Births
- 2 Colonic Adenomas
- 3 See also
- 4 References
Preterm Births
Research implicates periodontal disease caused by F. nucleatum with preterm births in humans. In many studies, F. nucleatum cells have been isolated from the amniotic fluid, placenta, and chorioamnionic membranes of women delivering prematurely. Moreover, laboratory mice inoculated with F. nucleatum have been found to deliver prematurely, and the pathology of the infection seems to mirror observations in humans.[3] Together, this research provides strong evidence for a causal connection between F. nucleatum-caused periodontal disease and at least some cases of preterm delivery.
Colonic Adenomas
F. nucleatum has a demonstrated association with colon cancer; in addition, a mechanism has been described by which F. nucleatum induces tumor growth without the more general mechanism of inducing inflammation or otherwise irritating the colon tissue. This suggests direct and specific carcinogenesis.[4]
See also
- List of bacterial vaginosis microbiota
References
- ^ Kapatral V et al. (2002). "Genome sequence and analysis of the oral bacterium 'Fusobacterium nucleatum' strain ATCC 25586.". J Bacteriol 184 (7): 2005–2018. doi:10.1128/JB.184.7.2005-2018.2002. PMC 134920. PMID 11889109.
- ^ Signat B et al. (2011). "Fusobacterium nucleatum in Periodontal Health and Disease". Curr Iss Mol Biol 13 (2): 25–36.
- ^ http://iai.asm.org/cgi/content/short/72/4/2272
- ^ Kostic, AD; Chun, E; Robertson, L; Glickman, JN; Gallini, CA; Michaud, M; Clancy, TE; Chung, DC; Lochhead, P; Hold, GL; El-Omar, EM; Brenner, D; Fuchs, CS; Meyerson, M; Garrett, WS (Aug 14, 2013). "Fusobacterium nucleatum Potentiates Intestinal Tumorigenesis and Modulates the Tumor-Immune Microenvironment.". Cell host & microbe 14 (2): 207–15. doi:10.1016/j.chom.2013.07.007. PMID 23954159.
- Infectious diseases
- Bacterial diseases: BV4 non-proteobacterial G- (primarily A00–A79, 001–041, 080–109)
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Spirochaete |
Spirochaetaceae |
Treponema |
- Treponema pallidum
- Treponema carateum (Pinta)
- Treponema denticola
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Borrelia |
- Borrelia burgdorferi/Borrelia afzelii
- Lyme disease
- Erythema chronicum migrans
- Neuroborreliosis
- Borrelia recurrentis (Louse borne relapsing fever)
- Borrelia hermsii/Borrelia duttoni/Borrelia parkeri (Tick borne relapsing fever)
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Leptospiraceae |
Leptospira |
- Leptospira interrogans (Leptospirosis)
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Spirillaceae |
Spirillum |
- Spirillum minus (Rat-bite fever/Sodoku)
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|
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Chlamydiaceae |
Chlamydophila |
- Chlamydophila psittaci (Psittacosis)
- Chlamydophila pneumoniae
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Chlamydia |
- Chlamydia trachomatis
- Chlamydia
- Lymphogranuloma venereum
- Trachoma
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Bacteroidetes |
- Bacteroides fragilis
- Tannerella forsythia
- Capnocytophaga canimorsus
- Porphyromonas gingivalis
- Prevotella intermedia
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Fusobacteria |
- Fusobacterium necrophorum (Lemierre's syndrome)
- Fusobacterium nucleatum
- Fusobacterium polymorphum
- Streptobacillus moniliformis (Rat-bite fever/Haverhill fever)
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Index of bacterial disease
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Description |
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Disease |
- Gram-positive firmicutes
- Gram-positive actinobacteria
- Gram-negative proteobacteria
- Gram-negative non-proteobacteria
- Cholera
- Tuberculosis
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|
Treatment |
- Antibiotics
- cell wall
- nucleic acid
- mycobacteria
- protein synthesis
- other
- Antibodies
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UpToDate Contents
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English Journal
- Subgingival microbiota in adult Down syndrome periodontitis.
- Khocht A, Yaskell T, Janal M, Turner BF, Rams TE, Haffajee AD, Socransky SS.SourceTemple University School of Dentistry, Philadelphia, PA, USA The Forsyth Institute, Cambridge, MA, USA New York University College of Dentistry, New York, NY, USA East Central Regional Hospital, Gracewood, GA, USA.
- Journal of periodontal research.J Periodontal Res.2012 Aug;47(4):500-7. doi: 10.1111/j.1600-0765.2011.01459.x. Epub 2012 Jan 3.
- Khocht A, Yaskell T, Janal M, Turner BF, Rams TE, Haffajee AD, Socransky SS. Subgingival microbiota in adult Down syndrome periodontitis. J Periodont Res 2012; 47: 500-507. © 2012 John Wiley & Sons A/S Background and Objective: The subgingival microbiota in Down syndrome and non-Down syndrom
- PMID 22221039
- Investigation and quantification of key periodontal pathogens in patients with type 2 diabetes.
- Field CA, Gidley MD, Preshaw PM, Jakubovics N.SourceSchool of Dental Sciences, Newcastle University, Newcastle, UK School of Clinical Dentistry, University of Sheffield, Sheffield, UK Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, UK.
- Journal of periodontal research.J Periodontal Res.2012 Aug;47(4):470-8. doi: 10.1111/j.1600-0765.2011.01455.x. Epub 2012 Jan 3.
- Field CA, Gidley MD, Preshaw PM, Jakubovics N. Investigation and quantification of key periodontal pathogens in patients with type 2 diabetes. J Periodont Res 2012; 47: 470-478. © 2012 John Wiley & Sons A/S Background and Objective: Diabetes is a recognized risk factor for periodontitis. The
- PMID 22220967
Japanese Journal
- Fusobacterium nucleatum ATCC 25586におけるトリプトファンからのインドール産生能とそれらのバイオフィルム形成への影響(岩手医科大学学位審査報告)
- Fusobacterium nucleatumがPorphyromonas gingivalisの宿主細胞への侵入に及ぼす影響 (平成21年度東京歯科大学口腔科学研究センターワークショップ) -- (プロジェクト7 口腔アンチエイジングによる生体制御--各グループによる研究進捗状況報告)
- 遠山 歳三,澤田 智史,高橋 祐介,李 昌一,浜田 信城,塗々木 和男
- 歯科薬物療法 30(2), 51-56, 2011
- … To examine an antimicrobial effect of the Jixueteng against oral bacteria, we mixed bacterial suspension of Actinomyces viscosus, Streptococcus mutans, Aggregatibacter actinomycetemcomitans, Fusobacterium nucleatum, Porphyromonas gingivalis, Veillonella parvula or Candida albicans with a water extract of the Jixueteng to calculate a survival rate by a cultural method. … nucleatum, P. …
- NAID 130001402894
Related Links
- Gram-negative stained culture of F. nucleatum. Image Courtesy of J. Michael Miller, Ph.D.,(D)ABMM of National Center for Zoonotic, Vector-borne, and Enteric ... Fusobacterium nucleatum is a bacterium that is commonly found in ...
- Fusobacterium nucleatum is an oral bacterium, indigenous to the human oral cavity, that plays a role in periodontal disease. This organism is commonly recovered from different monomicrobial and mixed infections in humans and ...
- Fusobacterium nucleatum フソバクテリウム・ヌクレアタム 系統 抗菌薬 感受性 標準菌株 標準菌のMIC 臨床分離菌のMIC80 臨床分離菌のMIC60 備考 ペニシリン系 Piperacillin <0.10 ペニシリン系 Tazobactam / Piperacillin ≦0.05 ...
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