WordNet
- exempt by means of an official pass or letter, as from customs or other checks
- a smooth-textured sausage of minced beef or pork usually smoked; often served on a bread roll (同)frankfurter, hotdog, hot dog, dog, wiener, wienerwurst, weenie
- clearly manifest; evident; "frank enjoyment"
- the trace of a point whose direction of motion changes (同)curved shape
- a pitch of a baseball that is thrown with spin so that its path curves as it approaches the batter (同)curve ball, breaking ball, bender
- a line on a graph representing data
- a member of the ancient Germanic peoples who spread from the Rhine into the Roman Empire in the 4th century
- an inferior dog or one of mixed breed (同)mongrel, mutt
- a cowardly and despicable person
- gregarious birds native to the Old World
PrepTutorEJDIC
- 『率直な』,隠しだてをしない
- 無料郵送の印・無料郵送の特典・無料郵送の郵便物・〈郵便物〉‘に'料金別納郵便の印を押す・〈公的郵便物〉無料で郵送する
- =frankfurter
- 『曲線』 / 『曲がり』,曲がったもの,湾曲部 / (野球で投球の)『カーブ』 / (…の方へ)『曲がる』,湾曲する《+『to』+『名』》 / …'を'曲げる;'を'湾曲させる
- フランク人(6世紀にゴール人を征服し広大な王国を建設してFranceという名称の起源となったゲルマン人)
- のら犬 / くだらない人間
- ホシムクドリ(人家の近くに群生する鳴鳥)
UpToDate Contents
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- 1. 心不全の病態生理：左心室の圧-容積とその他の血行動態の関係 pathophysiology of heart failure left ventricular pressure volume and other hemodynamic relationships
- 2. 心不全患者における利尿剤の使用 use of diuretics in patients with heart failure
- 3. 心腎症候群：定義、有病割合、診断および病態生理 cardiorenal syndrome definition prevalence diagnosis and pathophysiology
- 4. ループ利尿剤およびサイアザイド系利尿剤によって誘発された電解質の合併症の経過 time course of loop and thiazide diuretic induced electrolyte complications
- 5. 心腎症候群：予後および治療 cardiorenal syndrome prognosis and treatment
English Journal
- Does intravenous landiolol, a β1-adrenergic blocker, affect stroke volume variation?
- Wajima Z1, Shiga T, Imanaga K, Inoue T.Author information 1Department of Anesthesiology, Shioya Hospital, International University of Health and Welfare, 77 Tomita, Yaita, Tochigi, 329-2145, Japan, HFB01245@nifty.com.AbstractPURPOSE: There are no reports about the effect of bradycardia on stroke volume variation (SVV), and we hypothesized that induced bradycardia alters the value of SVV. Landiolol, an ultra-short-acting adrenergic β1-receptor blocking agent, was reported to induce bradycardia without decreasing blood pressure. The initial aim of this prospective study was to investigate changes in SVV values by induced bradycardia in patients with good cardiac function.
- Journal of anesthesia.J Anesth.2013 Dec;27(6):890-4. doi: 10.1007/s00540-013-1622-8. Epub 2013 May 8.
- PURPOSE: There are no reports about the effect of bradycardia on stroke volume variation (SVV), and we hypothesized that induced bradycardia alters the value of SVV. Landiolol, an ultra-short-acting adrenergic β1-receptor blocking agent, was reported to induce bradycardia without decreasing blood p
- PMID 23653103
- Depressed Frank-Starling mechanism in the left ventricular muscle of the knock-in mouse model of dilated cardiomyopathy with troponin T deletion mutation ΔK210.
- Inoue T1, Kobirumaki-Shimozawa F, Kagemoto T, Fujii T, Terui T, Kusakari Y, Hongo K, Morimoto S, Ohtsuki I, Hashimoto K, Fukuda N.Author information 1Department of Cell Physiology, The Jikei University School of Medicine, Tokyo, Japan; Department of Cardiac Surgery, The Jikei University School of Medicine, Tokyo, Japan.AbstractIt has been reported that the Frank-Starling mechanism is coordinately regulated in cardiac muscle via thin filament "on-off" equilibrium and titin-based lattice spacing changes. In the present study, we tested the hypothesis that the deletion mutation ΔK210 in the cardiac troponin T gene shifts the equilibrium toward the "off" state and accordingly attenuate the sarcomere length (SL) dependence of active force production, via reduced cross-bridge formation. Confocal imaging in isolated hearts revealed that the cardiomyocytes were enlarged, especially in the longitudinal direction, in ΔK210 hearts, with striation patterns similar to those in wild type (WT) hearts, suggesting that the number of sarcomeres is increased in cardiomyocytes but the sarcomere length remains unaltered. For analysis of the SL dependence of active force, skinned muscle preparations were obtained from the left ventricle of WT and knock-in (ΔK210) mice. An increase in SL from 1.90 to 2.20μm shifted the mid-point (pCa50) of the force-pCa curve leftward by ~0.21pCa units in WT preparations. In ΔK210 muscles, Ca(2+) sensitivity was lower by ~0.37pCa units, and the SL-dependent shift of pCa50, i.e., ΔpCa50, was less pronounced (~0.11pCa units), with and without protein kinase A treatment. The rate of active force redevelopment was lower in ΔK210 preparations than in WT preparations, showing blunted thin filament cooperative activation. An increase in thin filament cooperative activation upon an increase in the fraction of strongly bound cross-bridges by MgADP increased ΔpCa50 to ~0.21pCa units. The depressed Frank-Starling mechanism in ΔK210 hearts is the result of a reduction in thin filament cooperative activation.
- Journal of molecular and cellular cardiology.J Mol Cell Cardiol.2013 Oct;63:69-78. doi: 10.1016/j.yjmcc.2013.07.001. Epub 2013 Jul 14.
- It has been reported that the Frank-Starling mechanism is coordinately regulated in cardiac muscle via thin filament "on-off" equilibrium and titin-based lattice spacing changes. In the present study, we tested the hypothesis that the deletion mutation ΔK210 in the cardiac troponin T gene shifts th
- PMID 23863340
- Goal-directed intraoperative fluid therapy guided by stroke volume and its variation in high-risk surgical patients: a prospective randomized multicentre study.
- Scheeren TW1, Wiesenack C, Gerlach H, Marx G.Author information 1Department of Anaesthesiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands. t.w.l.scheeren@umcg.nlAbstractPerioperative hemodynamic optimisation improves postoperative outcome for patients undergoing high-risk surgery (HRS). In this prospective randomized multicentre study we studied the effects of an individualized, goal-directed fluid management based on continuous stroke volume variation (SVV) and stroke volume (SV) monitoring on postoperative outcomes. 64 patients undergoing HRS were randomized either to a control group (CON, n = 32) or a goal-directed group (GDT, n = 32). In GDT, SVV and SV were continuously monitored (FloTrac/Vigileo) and patients were brought to and maintained on the plateau of the Frank-Starling curve (SVV <10 % and SV increase <10 % in response to fluid loading). Organ dysfunction was assessed using the SOFA score and resource utilization using the TISS score. Patients were followed up to 28 days for postoperative complications. Main outcome measures were the number of complications (infectious, cardiac, respiratory, renal, hematologic and abdominal post-operative complications), maximum SOFA score and cumulative TISS score during ICU stay, duration of mechanical ventilation, length of ICU stay, and time until fit for discharge. 12 patients had to be excluded from final analysis (6 in each group). During surgery, GDT received more colloids than CON (1,589 vs. 927 ml, P < 0.05) and SVV decreased in GDT (from 9.0 to 8.0 %, P < 0.05) but not in CON. The number of postoperative wound infections was lower in GDT (0 vs. 7, P < 0.01). Although not statistically significant, the proportion of patients with at least one complication (46 vs. 62 %), the number of postoperative complications per patient (0.65 vs. 1.40), the maximum sofa score (5.9 vs. 7.2), and the cumulative TISS score (69 vs. 83) tended to be lower. This multicentre study shows that fluid management based on a SVV and SV optimisation protocol is feasible and decreases postoperative wound infections. Our findings also suggest that a goal-directed strategy might decrease postoperative organ dysfunction.
- Journal of clinical monitoring and computing.J Clin Monit Comput.2013 Jun;27(3):225-33. doi: 10.1007/s10877-013-9461-6. Epub 2013 Apr 5.
- Perioperative hemodynamic optimisation improves postoperative outcome for patients undergoing high-risk surgery (HRS). In this prospective randomized multicentre study we studied the effects of an individualized, goal-directed fluid management based on continuous stroke volume variation (SVV) and st
- PMID 23558909
Japanese Journal
- Physiological and Pathophysiological Modulation of Calcium Signaling in Myocardial Cells : 54th Annual Scientific Session of the Japanese Circulation Society
- ENDOH MASAO
- Japanese circulation journal 55(11), 1108-1117, 1991-11-20
- … The length-dependent regulation of contractility (length-tension relationship in vitro or Frank-Starling's law, or ventricular function curve in situ) is achieved essentially by mechanism (2). …
- NAID 110002595589
- The concept of preload and its evaluation in the intact left ventricle.
- RAZZOLINI Renato,BOFFA Giovanni Maria,RAMONDO Angelo,DALIENTO Luciano,STRITONI Paolo,CHIOIN Raffaello,DALLA-VOLTA Sergio
- Ｊａｐａｎｅｓｅ Ｈｅａｒｔ Ｊｏｕｒｎａｌ 31(1), 1-13, 1990
- … Preload affects left ventricular pump function through the FrankStarling curve by changing sarcomere length. …
- NAID 130000765472
- Experimental evaluation of the linearized frank - Staling relationship (LFSR) in unloaded left ventrocle under assisted circulation in dogs.
- 松若 良介,松田 暉,中埜 粛,大谷 正勝,笹子 佳門,高見 宏,松木 修,加藤 雅明,正井 崇史,川島 康生
- 人工臓器 18(2), 448-451, 1989
- … The correlation(r) between stroke work determined as P-V curve area and end diastolic volume was high as ranging from 0.967 to 0.991. …
- NAID 130001734122
Related Links
- There is no single Frank-Starling curve on which the ventricle operates. Instead, there is a family of curves, each of which is defined by the afterload and inotropic state of the heart. In the figure showing multiple curves, the red ...
- Digoxin has a positive inotropic effect, shifts the Frank-Starling curve upward and leftward, and results in greater stroke volume generation for a given myocardial contraction, [2] achieved through altered balance in the ...
Related Pictures
★リンクテーブル★
| リンク元 | 「心機能曲線」「フランク・スターリングの曲線」 |
| 関連記事 | 「frank」「curve」「Starling curve」「Starling」 |
「心機能曲線」
SP.
- 左室拡張終期圧-一回仕事量の関係をプロットした曲線
- 心拍数に依存しない曲線 (2007年度後期生理学授業プリント)
「フランク・スターリングの曲線」
「frank」
- adj.
- 率直な、包み隠しのない、紛れもない
- (医)明らかな、はっきりとした
- residual schizophrenia:subsequent residual symptoms but no current frank psychotic symtoms.
「curve」
- n.
- v.
「Starling curve」
「Starling」
スターリング、(鳥類)クドリ