WordNet

the 1st letter of the Roman alphabet (同)a
the blood group whose red cells carry the A antigen (同)type_A, group A
the blood group whose red cells carry both the A and B antigens (同)type_AB, group AB
the 6th letter of the Roman alphabet (同)f

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/09 16:05:17」(JST)

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The fluorescent treponemal antibody absorption (FTA-ABS) test is a diagnostic test for syphilis. Using antibodies specific for the Treponema pallidum species, such tests would be assumed to be more specific than non-treponemal testing such as VDRL, but have been shown repeatedly to be sensitive but not specific for the diagnosis of neurosyphilis in CSF. In addition, FTA-ABS turns positive earlier and remains positive longer than VDRL. Other treponemes, such as T. pertenue, may also produce a positive FTA-ABS. The ABS suffix refers particularly to a processing step used to remove nonspecific antispirochetal antibodies present in normal serum.

In general, the test has two roles:

As a confirmatory test for a positive result from a serum screening test (RPR for example).
Since the test has high negative predictive value it is very useful in both serum or CSF to exclude/rule out neurosyphilis if the FTA test result is negative. " A negative FTA in serum excludes neurosyphilis".

Procedure

The antigen for the FTA-ABS test is whole bacteria. The bacteria cannot be cultured on laboratory media, so the organisms used are a lyophilized suspension of T. pallidum extracted from rabbit testicular tissue. This is spread over and fixed to a slide. Patient serum is mixed with an absorbent (the "ABS" part of the test) containing an extract of a non-pathogenic treponeme, Treponema phagedenis biotype Rieter. The purpose of the absorbent is to remove anti-treponemal antibodies that are not specific for the syphilis bacteria. The pre-adsorbed patient serum is then added to the slide; if the patient has been infected by syphilis, their antibodies will bind to the bacteria. FITC (a fluorophore)-labeled anti-treponeme antibody and TRITC (another fluorophore)-labeled anti-human antibodies are added as secondary antibodies. The spirochete location is identified using the FITC staining and the TRITC staining identifies whether the patient has anti-T. pallidum antibodies (binding to the same spirochete).

Utility

This test is not useful for following therapy, because it does not wane with successful treatment of the disease, and will continue to be positive for many years after primary exposure.^[1]

References

^ Singh, Ameeta E.; Barbara Romanowski (1 April 1999). "Syphilis: Review with Emphasis on Clinical, Epidemiologic, and Some Biologic Features". Clinical Microbiology Reviews 12 (2): 187–209. PMC 88914. PMID 10194456.

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UpToDate Contents

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1. 梅毒の診断的検査 diagnostic testing for syphilis
2. 神経梅毒 neurosyphilis
3. 妊娠中の梅毒 syphilis in pregnancy
4. 性器潰瘍患者へのアプローチ approach to the patient with genital ulcers
5. 先天梅毒：評価、マネージメント、および予防 congenital syphilis evaluation management and prevention

English Journal

[Isolated iliac aneurisma and positive FTA-Abs test].

Sáinz F, Alonso MN1, Barberán J, Fernández-Domínguez M, Pérez-Piqueras A.
Revista española de quimioterapia : publicación oficial de la Sociedad Española de Quimioterapia.Rev Esp Quimioter.2015 Jun;28(3):160-1.
PMID 26033002

Syphilitic hepatitis: rare or just unrecognized?

Vukšić Polić M1, Plužarić V, Kuric I.
Acta dermatovenerologica Croatica : ADC.Acta Dermatovenerol Croat.2015 Apr;23(1):70-1.
Syphilis is a chronic, infectious, sexually transmitted disease caused by Treponema pallidum and can affect all tissues and all organs (1). Untreated syphilis progresses through four stages: primary, secondary, latent and tertiary (1). Among the less common manifestations of the secondary stage is s
PMID 25969918

Syphilis related to atypical oral lesions affecting an elderly man. a case report.

Araujo JP1, Jaguar GC, Alves FA.
Gerodontology.Gerodontology.2015 Mar;32(1):73-5. doi: 10.1111/ger.12047. Epub 2013 Jul 22.
OBJECTIVE: To present a case of oral syphilis in an old patient.BACKGROUND: Syphilis seems to be resurging mainly in the young. However, in the last twenty years, the elderly have become more susceptive to infectious diseases due to a more frequent use of sildenafil.CLINICAL REPORT: An 83-year-old m
PMID 23869511

Japanese Journal

硬口蓋に発生した口腔症状単独の第2期梅毒の1例

金子裕之,小野沢基太郎,矢野尚,阿部廣幸
日本口腔診断学会雑誌 27(1), 18-21, 2014
… Serological test levels for syphilis including RPR, TPHA and FTA-ABS gradually decreased.We report the details of this rare type of secondary syphilis and discuss recent syphilitic features. …
NAID 130003398153

非ウイルス性感染症梅毒血清反応(STS,FTA-ABS法,IgM-FTA-ABS法,TPHA法) (広範囲血液・尿化学検査免疫学的検査(第7版・3)その数値をどう読むか) -- (免疫学的検査感染症関連検査(抗原および抗体を含む))

本田まりこ
日本臨床 68(-) (980), 142-146, 2010-06
NAID 40017181729

上半規管裂隙症候群によるめまい例

正木義男
耳鼻咽喉科臨床 101(11), 835-839, 2008-11-01
… The findings on Treponema pallidum hemagglutination assay (TPHA and FTA-ABS) was negative. …
NAID 10024429968

Related Pictures

Treponema pallidum. - ppt video online carregar 1623_c673e3a6abea3a895dd4c3b0 Biocientífica » FTA ABS (SIFILIS) POR IMUNOFLUORESCENCIA - 140 TESTES | Interlab Test, syphilis (FTA-ABS). Causes, symptoms, treatment Test, syphilis (FTA-ABS) FTA-ABS Test: Principle, Procedure, Results and Interpretation - Syphilis: Clinical Aspects, Epidemiology, and Control - ppt video online download Mast Group Ltd. Providing high quality diagnostic products to customers worldwide RPR-VDRL (Serologic Tests for Syphilis) | Lab Tests | GLOWM

★リンクテーブル★

リンク元	「fluorescent treponemal antibody absorption test」
拡張検索	「FTA-ABS test」「FTA-ABS法」「FTA-ABS試験」
関連記事	「A」「ABS」「AB」「F」