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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/11/25 03:54:33」(JST)
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N-Formylmethionine leucyl-phenylalanine |
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IUPAC name
(2S)-2-[[(2S)-2-[[(2S)-2-Formamido-4-methylsulfanylbutanoyl]amino]-4-methylpentanoyl]amino]-3-phenylpropanoic acid
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Other names
F-Met-Leu-Phe
L-Phenylalanine, N-(N-(N-formyl-L-methionyl)-L-leucyl)-[1]
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Identifiers |
CAS number |
59880-97-6 Y |
PubChem |
443295 |
ChemSpider |
16125628 Y |
MeSH |
N-Formylmethionine+Leucyl-Phenylalanine |
Jmol-3D images |
Image 1 |
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OC(=O)C(NC=O)CCSC.CC(C)CC(N)C(=O)NC(Cc1ccccc1)C(O)=O
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InChI=1S/C15H22N2O3.C6H11NO3S/c1-10(2)8-12(16)14(18)17-13(15(19)20)9-11-6-4-3-5-7-11;1-11-3-2-5(6(9)10)7-4-8/h3-7,10,12-13H,8-9,16H2,1-2H3,(H,17,18)(H,19,20);4-5H,2-3H2,1H3,(H,7,8)(H,9,10) Y
Key: HFSVAEOILMOWDY-UHFFFAOYSA-N Y
InChI=1/C15H22N2O3.C6H11NO3S/c1-10(2)8-12(16)14(18)17-13(15(19)20)9-11-6-4-3-5-7-11;1-11-3-2-5(6(9)10)7-4-8/h3-7,10,12-13H,8-9,16H2,1-2H3,(H,17,18)(H,19,20);4-5H,2-3H2,1H3,(H,7,8)(H,9,10)
Key: HFSVAEOILMOWDY-UHFFFAOYAS
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Properties |
Molecular formula |
C21H31N3O5S |
Molar mass |
437.55 g/mol |
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa) |
Y (verify) (what is: Y/N?) |
Infobox references |
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N-Formylmethionyl-leucyl-phenylalanine is a formylated tripeptide originally isolated from bacterial filtrates that is positively chemotactic to polymorphonuclear leucocytes, and causes them to release lysosomal enzymes and become metabolically activated.[clarification needed][2]
References
- ^ n-formylmethionine leucyl-phenylalanine, Cancerweb
- ^ N-Formylmethionyl-leucyl-phenylalanine, Medical Dictionary Online
UpToDate Contents
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English Journal
- Glycogen storage disease type Ib neutrophils exhibit impaired cell adhesion and migration.
- Kim GY1, Lee YM1, Kwon JH1, Jun HS2, Chou J3.
- Biochemical and biophysical research communications.Biochem Biophys Res Commun.2017 Jan 22;482(4):569-574. doi: 10.1016/j.bbrc.2016.11.075. Epub 2016 Nov 15.
- Glycogen storage disease type Ib (GSD-Ib), characterized by impaired glucose homeostasis, neutropenia, and neutrophil dysfunction, is an inherited autosomal recessive disorder caused by a deficiency in the glucose-6-phosphate transporter (G6PT). Neutrophils play an essential role in the defense agai
- PMID 27864142
- MFG-E8-derived peptide attenuates adhesion and migration of immune cells to endothelial cells.
- Hirano Y1,2, Yang WL1,3, Aziz M1, Zhang F1, Sherry B1, Wang P4,3.
- Journal of leukocyte biology.J Leukoc Biol.2017 Jan 17. pii: jlb.3A0416-184RR. doi: 10.1189/jlb.3A0416-184RR. [Epub ahead of print]
- Milk fat globule-epidermal growth factor-factor 8 (MFG-E8) plays an immunomodulatory role in inflammatory diseases. MFG-E8-derived short peptide (MSP68) greatly reduces neutrophil infiltration and injury in the lung during sepsis. In this study, we examined the effect of MSP68 on chemotaxis of vario
- PMID 28096298
- Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B4 production.
- Okuno T1, Koutsogiannaki S2,3, Ohba M1, Chamberlain M2, Bu W4, Lin FY5, Eckenhoff RG4, Yokomizo T1, Yuki K6,3.
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology.FASEB J.2017 Jan 9. pii: fj.201601095R. doi: 10.1096/fj.201601095R. [Epub ahead of print]
- Propofol is an intravenous anesthetic that produces its anesthetic effect, largely via the GABAA receptor in the CNS, and also reduces the N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced neutrophil respiratory burst. Because fMLP-stimulated neutrophils produce leukotriene (LT)B4, we examined
- PMID 28069825
Japanese Journal
- 微小循環モデルにおけるシロスタゾールとGPIIb/IIIa阻害薬の血液レオロジーに及ぼす影響
- Anethole and eugenol reduce in vitro and in vivo leukocyte migration induced by fMLP, LTB₄, and carrageenan
- P2Y₁₁ Purinoceptor Mediates the ATP-Enhanced Chemotactic Response of Rat Neutrophils
- Journal of pharmacological sciences 120(4), 288-295, 2012-12-20
- NAID 10031147577
Related Links
- 著者らは、fMLPがヒト好中球によるLTB 4 の分泌を誘導することを確認し、ウェスタンブロット解析によって、LTB 4 産生の薬理学的遮断(AAを代謝する酵素の阻害による)、あるいは競合薬によるLTB 4 受容体(BLT1)の遮断は、fMLP 4 ...
- クローン REA169 は、N-formyl-L-methionyl-L-leucyl-phenylalanine レセプター (fMLP receptor) を認識します。fMLP レセプターは、7回膜貫通型でGタンパク質共役型のレセプターです。fMLP レセプターは、fMLP などのホルミル化ペプチドに ...
Related Pictures
★リンクテーブル★
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ホルミルメチオニルロイシルフェニルアラニン
- 関
- formylmethionylleucylphenylalanine