同: diethylaminoethyl

同: diethylaminoethyl

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Diethylethanolamine can be used as a precursor chemical to procaine. It can be reacted with 4-aminobenzoic acid to make procaine.

Applications

Diethylethanolamine is used as a corrosion inhibitor in steam and condensate lines by neutralizing carbonic acid and scavenging oxygen.

Preparation

Diethylethanolamine is prepared commercially by the reaction of diethylamine and ethylene oxide.^[2]

(C₂H₅)₂NH + (CH₂CH₂)O → (C₂H₅)₂NCH₂CH₂OH

It is also possible to prepare it by the reaction of diethylamine and ethylene chlorohydrin.^[3]

Safety

Diethylethanolamine is an irritant to the eyes, skin, and respiratory system. The Occupational Safety and Health Administration and the National Institute for Occupational Safety and Health have set occupational exposure limits for workers handling the chemical at 10 ppm (50 mg/m³) over an eight-hour workday.^[4]

References

^ ^a ^b ^c ^d ^e "NIOSH Pocket Guide to Chemical Hazards #0210". National Institute for Occupational Safety and Health (NIOSH).
^ Bollmeier, Jr., Allen F. (1999). "Alkanolamines". In Kroschwitz, Jacqueline I. Kirk-Othmer Encylclopedia of Chemical Technology 2 (4th ed.). New York: John Wiley & Sons, Inc. pp. 1–34. ISBN 978-0471419617.
^ "Diethylaminoethanol". USDA. 2001-2-15. Retrieved 2012-08-28. Check date values in: |date= (help)
^ "NIOSH Pocket Guide to Chemical Hazards". CDC. 2011-04-04. Retrieved 11/8/2013. Check date values in: |accessdate= (help)

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A SUPEROXIDE DISMUTASE PURIFIED FROM THE ROOTS FROM Stemona tuberosa.

Niyomploy P1, Boonsombat R, Karnchanatat A, Sangvanich P.
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Proteins from the fresh roots of Stemona tuberosa (Stemonaceae) were extracted into 20 mM phosphate buffer, pH 7.2/0.1 M NaCl, precipitated with 90% saturation ammonium sulfate, and enriched by diethylaminoethanol (DEAE) cellulose. The protein eluted as a single main peak from the unbound fractions
PMID 24279794

Expression and immunogenic analysis of recombinant polypeptides derived from capsid protein VP1 for developing subunit vaccine material against hepatitis A virus.

Jang KO1, Park JH1, Lee HH1, Chung DK2, Kim W3, Chung IS4.
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Three recombinant polypeptides, VP1-His, VP1-3N-His, and 3D2-His, were produced by Escherichia coli expression system. Recombinant VP1-His, VP1-3N-His, and 3D2-His were expressed as bands with molecular weights of 32, 38, and 30kDa, respectively. These were purified by affinity chromatography using
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Structural characterisation of algae Costaria costata fucoidan and its effects on CCl₄-induced liver injury.

Wang Q1, Song Y2, He Y3, Ren D4, Kow F5, Qiao Z6, Liu S7, Yu X8.
Carbohydrate polymers.Carbohydr Polym.2014 Jul 17;107:247-54. doi: 10.1016/j.carbpol.2014.02.071. Epub 2014 Mar 5.
Fucoidan is a well-known natural product that is commonly found in brown algae and shows a variety of activities, including immunomodulation, antioxidation, and the combat of carcinogens. The fucoidan fractions of Costaria costata, a brown algae introduced from Japan and cultured in northern China,
PMID 24702942

Japanese Journal

Characterization of a β-D-mannosidase from a marine gastropod, Aplysia kurodai

Zahura Umme Afsari,Rahman Mohammad Matiur,Inoue Akira,Ojima Takao
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 162(1-3), 24-33, 2012-05
… A β-D-mannosidase (EC 3.2.1.25) with a molecular mass of approximately 100 kDa was purified from the digestive fluid of a marine gastropod Aplysia kurodai by ammonium sulfate fractionation followed by column chromatographies on TOYOPEARL Butyl-650 M, TOYOPEARL DEAE-650 M, and Superdex 200 10/300 GL. …
NAID 120004146563

好熱性細菌Thermus sp.O-3-1由来耐熱性アミダーゼの精製及び性質検討

小林史明,青峰弘起,水無渉,湯不二夫,田村隆,稲垣賢二
岡山大学農学部学術報告 101, 1-6, 2012-02-01
… ーニングし，その塩基配列を決定した．ami 遺伝子は930 bp からなり，310アミノ酸をコードしていた．本酵素の分子量は33，089 Daであると予想された．Thermus sp.O-3-1 由来アミダーゼを大腸菌で生産させ，熱処理とDEAE-トヨパール650M陰イオン交換カラム等により精製した．ゲル濾過クロマトグラフィーとSDS-PAGE の結果から本酵素は分子質量33 kDa のサブユニット2分子からなるダイマー構造を有していることが明らかとなった． …
NAID 120003752065

Cordysobin, a novel alkaline serine protease with HIV-1 reverse transcriptase inhibitory activity from the medicinal mushroom Cordyceps sobolifera(ENZYMOLOGY, PROTEIN ENGINEERING, AND ENZYME TECHNOLOGY)

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Journal of bioscience and bioengineering 113(1), 42-47, 2012-01
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リンク元	「ジエチルアミノエチル」「diethylaminoethyl」
関連記事	「DE」

「ジエチルアミノエチル」

Diethylethanolamine
Names
	IUPAC name 2-(Diethylamino)ethanol
	Other names Diethylaminoethanol; 2-Diethylaminoethanol; N,N-Diethyl-2-aminoethanol; N,N-Diethylethanolamine; Diethyl(2-hydroxyethyl)amine; (2-Hydroxyethyl)diethylamine; 2-Diethylaminoethyl alcohol; 2-Hydroxytriethylamine;
Identifiers
Beilstein Reference	741863
CAS Registry Number	100-37-8
ChEBI	CHEBI:52153
ChEMBL	ChEMBL1183
ChemSpider	13842001
EC number	202-845-2
	InChI InChI=1S/C6H15NO/c1-3-7(4-2)5-6-8/h8H,3-6H2,1-2H3 ; Key: BFSVOASYOCHEOV-UHFFFAOYSA-N ;
Jmol-3D images	Image
MeSH	2-diethylaminoethanol
PubChem	7497
RTECS number	KK5075000
	SMILES CCN(CC)CCO ;
UN number	2686
Properties
Molecular formula	C6H15NO
Molar mass	117.19 g·mol−1
Appearance	Colourless liquid
Odor	Ammoniacal
Density	884 mg mL−1
Melting point	−70 °C; −94 °F; 203 K
Boiling point	161.1 °C; 321.9 °F; 434.2 K
Solubility in water	miscible
log P	0.769
Vapor pressure	100 Pa (at 20 °C)
Refractive index (nD)	1.441–1.442
Hazards
GHS pictograms
GHS signal word	DANGER
GHS hazard statements	H226, H302, H312, H314, H317, H332
GHS precautionary statements	P280, P305+351+338, P310
EU Index	603-048-00-6
EU classification	C
R-phrases	R10, R20/21/22, R34
S-phrases	(S1/2), S25, S26, S36/37/39, S45
Flash point	50 °C (122 °F; 323 K)
Explosive limits	1.4–11.7%
LD50 (Median lethal dose)	1.113 g kg−1 (dermal, rabbit); 1.3 g kg−1 (oral, rat);
	US health exposure limits (NIOSH):
PEL (Permissible)	TWA 10 ppm (50 mg/m3) [skin]
REL (Recommended)	TWA 10 ppm (50 mg/m3) [skin]
IDLH (Immediate danger)	100 ppm
Related compounds
Related alkanols	N-Methylethanolamine; Dimethylethanolamine; Diethanolamine; N,N-Diisopropylaminoethanol; Methyl diethanolamine; Triethanolamine; Bis-tris methane; Meglumine;
Related compounds	Diethylhydroxylamine
	Except where noted otherwise, data is given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
	Infobox references

　　[★]

英: [[]]
同: DEAE
関: [[]]

同: DEAE

「diethylaminoethyl」

　　[★]

ジエチルアミノエチル

関: DEAE

「DE」

　　[★] 線量当量 dose equivalent 　

[PGCH-1] "NIOSH Pocket Guide to Chemical Hazards #0210". National Institute for Occupational Safety and Health (NIOSH).

[2] Bollmeier, Jr., Allen F. (1999). "Alkanolamines". In Kroschwitz, Jacqueline I. Kirk-Othmer Encylclopedia of Chemical Technology 2 (4th ed.). New York: John Wiley & Sons, Inc. pp. 1–34. ISBN 978-0471419617.

[3] "Diethylaminoethanol". USDA. 2001-2-15. Retrieved 2012-08-28. Check date values in: |date= (help)

[4] "NIOSH Pocket Guide to Chemical Hazards". CDC. 2011-04-04. Retrieved 11/8/2013. Check date values in: |accessdate= (help)

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