- 同
- mucosal epithelial chemokine、MEC
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/05/26 11:19:14」(JST)
[Wiki en表示]
chemokine (C-C motif) ligand 28 |
Identifiers |
Symbol |
CCL28 |
Alt. symbols |
SCYA28, MEC, CCK1 |
Entrez |
56477 |
HUGO |
17700 |
OMIM |
605240 |
RefSeq |
NM_148672 |
UniProt |
Q9NRJ3 |
Other data |
Locus |
Chr. 5 p12 |
CCL28, also known as mucosae-associated epithelial chemokine (MEC), CCK1 and SCYA28, is a chemokine. CCL28 regulates the chemotaxis of cells that express the chemokine receptors CCR3 and CCR10. CCL28 is expressed by columnar epithelial cells in the gut, lung, breast and the salivary glands and drives the mucosal homing of T and B lymphocytes that express CCR10, and the migration of eosinophils expressing CCR3.[1][2][3] This chemokine is constitutively expressed in the colon, but its levels can be increased by pro-inflammatory cytokines and certain bacterial products implying a role in effector cell recruitment to sites of epithelial injury.[4] CCL28 has also been implicated in the migration of IgA-expressing cells to the mammary gland,[5] salivary gland, intestine[6] and other mucosal tissues.[7] It has also been shown as a potential antimicrobial agent effective against certain pathogens, such as Gram negative and Gram positive bacteria and the fungus Candida albicans.[8]
Human CCL28 is encoded by an RNA transcript of 373 nucleotides and a gene with four exons. The gene codes for a 127-amino acid CCL28 protein with a 22-amino acid N-terminal signal peptide. It shares 76% nucleic acid identity and 83% amino acid similarity to the equivalent molecule in mouse.[9][10] Sequence analysis has revealed CCL28 to be most similar to another CC chemokine called CCL27.
References
- ^ Rodriguez et al. 2004. Differential gene expression by integrin 7+ and 7– memory T helper cells. BMC Immunol. 5: 13.
- ^ Kunkel et al. 2003. CCR10 expression is a common feature of circulating and mucosal epithelial tissue IgA Ab-secreting cells. J. Clin. Invest. 111: 1001-1010.
- ^ John et al. 2005, Temporal production of CCL28 corresponds to eosinophil accumulation and airway hyperreactivity in allergic airway inflammation, Am. J. Pathol. 166: 345–353.
- ^ Hieshima et al. 2003. CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity. J. Immunol. 170: 1452-1461.
- ^ Wilson and Butcher. CCL28 controls immunoglobulin (Ig)A plasma cell accumulation in the lactating mammary gland and IgA antibody transfer to the neonate. J Exp Med. 2004 Sep 20;200(6):805-9.
- ^ Feng et al. Redundant role of chemokines CCL25/TECK and CCL28/MEC in IgA+ plasmablast recruitment to the intestinal lamina propria after rotavirus infection. J Immunol. 15 May 2006;176(10):5749-59.
- ^ Lazarus et al. A common mucosal chemokine (mucosae-associated epithelial chemokine/CCL28) selectively attracts IgA plasmablasts. J Immunol. 2003 Apr 1;170(7):3799-805
- ^ Hieshima et al. CCL28 has dual roles in mucosal immunity as a chemokine with broad-spectrum antimicrobial activity. J Immunol. 2003 Feb 1;170(3):1452-61.
- ^ Wang et al. 2000, Identification of a novel chemokine (CCL28), which binds CCR10 (GPR2). J. Biol. Chem. 275: 22313–22323.
- ^ Pan et al. 2000, A novel chemokine ligand for CCR10 and CCR3 expressed by epithelial cells in mucosal tissues, J. Immunol. 165: 2943–2949.
Cell signaling: cytokines
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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UpToDate Contents
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English Journal
- Intracellular signaling mechanisms associated with CD47 modified surfaces.
- Finley MJ, Clark KA, Alferiev IS, Levy RJ, Stachelek SJ.SourceDivision of Cardiology, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA.
- Biomaterials.Biomaterials.2013 Nov;34(34):8640-9. doi: 10.1016/j.biomaterials.2013.07.088. Epub 2013 Aug 13.
- We have previously established that recombinant CD47 can ameliorate the inflammatory response to synthetic polymeric surfaces. Here, we begin to profile, at the transcriptional, translational and cell signaling level, the inflammatory cell response when blood interacts with CD47 modified polyvinyl c
- PMID 23948164
- Whole genome expression profiling and screening for differentially expressed cytokine genes in human bone marrow endothelial cells treated with humoral inhibitors in liver cirrhosis.
- Gao B, Sun W, Wang X, Jia X, Ma B, Chang Y, Zhang W, Xue D.SourceDepartment of General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, P.R. China.
- International journal of molecular medicine.Int J Mol Med.2013 Nov;32(5):1204-14. doi: 10.3892/ijmm.2013.1495. Epub 2013 Sep 13.
- Bone marrow endothelial cells (BMECs) are important components of the hematopoietic microenvironment in bone marrow, and they can secrete several types of cytokines to regulate the functions of hematopoietic stem/progenitor cells. To date, it is unknown whether BMECs undergo functional changes and l
- PMID 24043211
- Chemokine CCL28 induces apoptosis of decidual stromal cells via binding CCR3/CCR10 in human spontaneous abortion.
- Sun C, Zhang YY, Tang CL, Wang SC, Piao HL, Tao Y, Zhu R, Du MR, Li DJ.SourceLaboratory for Reproductive Immunology, Hospital and Institute of Obstetrics and Gynecology, IBS, Fudan University Shanghai Medical College, Shanghai 200011, China.
- Molecular human reproduction.Mol Hum Reprod.2013 Oct;19(10):676-86. doi: 10.1093/molehr/gat038. Epub 2013 Jun 4.
- Spontaneous abortion is the most common complication of pregnancy. Immune activation and the subsequent inflammation-induced tissue injury are often observed at the maternal-fetal interface as the final pathological assault in recurrent spontaneous abortion. However, the precise mechanisms responsib
- PMID 23737337
Japanese Journal
- 泌乳マウスの乳腺における免疫グロブリンA産生に及ぼすガラクトオリゴ糖の影響
- ALIMENTARY TRACT 小腸上皮発現TLRは腸管局所へのB細胞遊走とIgA産生を促進する
- Review of gastroenterology & clinical gastroenterology and hepatology 3(4), 23-26, 2009-02
- NAID 40016473790
- イヌのアトピー性皮膚炎病変部および非病変部におけるCCL27およびCCL28 mRNAの発現解析(内科学)
Related Links
- Complete information for CCL28 gene (protein-coding), chemokine (C-C motif) ligand 28, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium ... Identification of a ...
- MEC(CCL28), ヒト, 組換え体 MEC(CCL28), Human, recombinant 販売元 和光純薬工業(株) 販売元コード 132-16741 製造元 製造元コード CAS.NO 分子式 分子量 保存条件 冷凍 (ドライアイス輸送) 適用法規 危険有害性 等級 細胞生物 ...
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★リンクテーブル★
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セファクロル cefaclor