バーベック顆粒
WordNet
- a tiny grain
PrepTutorEJDIC
- 小粒,微粒
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/09/10 10:42:34」(JST)
[Wiki en表示]
Birbeck granules, also known as Birbeck bodies, are rod shaped[1] or "tennis-racket" cytoplasmic organelles with a central linear density and a striated appearance. They are a characteristic microscopic finding in Langerhans cell histiocytosis (Histiocytosis X), which is one of a group of rare conditions collectively known as histiocytosis.
Formation is induced by langerin.[2]
Contents
- 1 Function
- 2 History
- 3 References
- 4 External links
Function[edit source | edit]
Function is under question, but one theory is that they migrate to the periphery of the Langerhans cells and release its contents into the extracellular matrix. Another theory is that the Birbeck granule functions in receptor-mediated endocytosis, similar to clathrin-coated pits.
History[edit source | edit]
Birbeck granules were discovered by Michael Stanley Clive Birbeck (1925–2005), a British scientist and electron microscopist who worked at the Chester Beatty Cancer Research Institute or Institute of Cancer Research, London from 1950 until 1981.[3]
References[edit source | edit]
- ^ Mc Dermott R, Ziylan U, Spehner D, et al. (January 2002). "Birbeck granules are subdomains of endosomal recycling compartment in human epidermal Langerhans cells, which form where Langerin accumulates". Mol. Biol. Cell 13 (1): 317–35. doi:10.1091/mbc.01-06-0300. PMC 65091. PMID 11809842.
- ^ Kissenpfennig A, Aït-Yahia S, Clair-Moninot V, et al. (January 2005). "Disruption of the langerin/CD207 gene abolishes Birbeck granules without a marked loss of Langerhans cell function". Mol. Cell. Biol. 25 (1): 88–99. doi:10.1128/MCB.25.1.88-99.2005. PMC 538791. PMID 15601833.
- ^ synd/2221 at Who Named It?
External links[edit source | edit]
- Image at ouhsc.edu
- Image at humpath.com
Eponymous medical signs for hematology
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Inclusion bodies |
- erythrocyte
- Cabot rings
- Howell-Jolly body
- Pappenheimer bodies
- Heinz body
- neutrophil (Döhle bodies)
- plasma cell (Russell bodies)
- histiocyte (Birbeck granules)
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Tests |
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Other |
- Arneth count
- Mentzer index
- Virchow's triad
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cell/phys (coag, heme, immu, gran), csfs
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rbmg/mogr/tumr/hist, sysi/epon, btst
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drug (B1/2/3+5+6), btst, trns
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UpToDate Contents
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English Journal
- Langerhans cell histiocytosis preceding the development of juvenile xanthogranuloma: a case and review of recent developments.
- Bains A, Parham DM.SourceDepartment of Pathology, Oklahoma University Health Sciences Center, Oklahoma City, OK, USA. ashi.bains@gmail.com
- Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society.Pediatr Dev Pathol.2011 Nov-Dec;14(6):480-4. Epub 2011 Jul 27.
- Langerhans cell histiocytosis (LCH) and juvenile xanthogranuloma (JXG) both belong to the histiocytosis group of disorders, which have varied prognostic and clinical significance. Their normal cellular counterparts share a common CD34-positive hematopoietic stem cell precursor that matures along CD1
- PMID 21793710
- Ontogeny and disease responses of Langerhans-like cells in lymphoid tissues of salmonid fish.
- Lovy J, Savidant GP, Wright GM.SourceDepartment of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Canada. Jan.Lovy@dfo-mpo.gc.ca
- Cell and tissue research.Cell Tissue Res.2011 Oct;346(1):111-8. Epub 2011 Oct 1.
- The ontogeny and disease responses of Langerhans-like cells within lymphoid tissues of Atlantic salmon, Salmo salar, and rainbow trout, Oncorhynchus mykiss, were investigated. These cells were studied in situ with the use of two markers: the ultrastructural presence of Birbeck-like granules and immu
- PMID 21965123
Japanese Journal
- Vitamin A Deficiency in Rats Induces Langerhans Cells in the Iliac Lymph Nodes Draining to the Squamous Metaplastic Urinary Bladder
- Journal of clinical and experimental hematopathology 44(1), 11-16, 2004-04-01
- NAID 10029513251
- Rod-shaped Bodies Resembling Birbeck Granule-like Structures in Endothelial Cells of Dermal Capillaries in Generalized Granuloma Annulare
- 頭部皮膚擦過細胞診標本にみられたLangerhans'cell histiocytosisに由来する細胞所見
Related Links
- Lan·ger·hans gran·ule (lahng'ĕr-hahnz), a small, tennis racket-shaped membrane-bound granule with characteristic cross-striated internal ultrastructure; first reported in Langerhans cells of the epidermis. See also: eosinophilic ...
- granule [gran´ūl] 1. a small particle or grain. 2. a small pill made of sucrose. acidophil g's granules staining with acid dyes. aleuronoid g's colorless myeloid colloidal bodies found in the base of pigment cells. alpha g's 1. oval granules ...
Related Pictures
![Birbeck granules](https://1mg.info/0/5/c/2905.jpg)
![Birbeck granules in Langerhans Cell](https://1mg.info/0/5/c/2906.jpg)
![birbeck_granule_04_5.jpg](https://1mg.info/0/5/c/2907.jpg)
![Birbeck granule. Note the rod-like](https://1mg.info/0/5/c/2908.jpg)
![Birbeck granule](https://1mg.info/0/5/c/2909.jpg)
★リンクテーブル★
[★]
- 英
- Birbeck granule, Birbeck granules
- 同
- Birbeck顆粒, ランゲルハンス顆粒 Langerhans granule
- 関
- Tゾーン組織球,ランゲルハンス細胞
[★]
- 関
- granular