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Utilization of major fucosylated and sialylated human milk oligosaccharides by isolated human gut microbes.

Yu ZT, Chen C, Newburg DS.SourceDepartment of Biology, Boston College, Chestnut Hill, MA 02467, USA.
Glycobiology.Glycobiology.2013 Nov;23(11):1281-92. doi: 10.1093/glycob/cwt065. Epub 2013 Sep 7.
Human milk oligosaccharides (HMOS) are not digested in the proximal intestine. In distal intestine, HMOS collectively modify the microbiota, but the response of individual bacteria to individual components of the HMOS is not well defined. Here, each of 25 major isolates of the human intestinal micro
PMID 24013960

Genetically dictated change in host mucus carbohydrate landscape exerts a diet-dependent effect on the gut microbiota.

Kashyap PC, Marcobal A, Ursell LK, Smits SA, Sonnenburg ED, Costello EK, Higginbottom SK, Domino SE, Holmes SP, Relman DA, Knight R, Gordon JI, Sonnenburg JL.SourceDepartment of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2013 Oct 15;110(42):17059-64. doi: 10.1073/pnas.1306070110. Epub 2013 Sep 23.
We investigate how host mucus glycan composition interacts with dietary carbohydrate content to influence the composition and expressed functions of a human gut community. The humanized gnotobiotic mice mimic humans with a nonsecretor phenotype due to knockout of their α1-2 fucosyltransferase (Fut2
PMID 24062455

Overexpression, crystallization and preliminary X-ray crystallographic analysis of a putative xylose isomerase from Bacteroides thetaiotaomicron.

Cho JW, Han BG, Park SY, Kim SJ, Kim MD, Lee BI.SourceDepartment of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Republic of Korea.
Acta crystallographica. Section F, Structural biology and crystallization communications.Acta Crystallogr Sect F Struct Biol Cryst Commun.2013 Oct;69(Pt 10):1127-30. doi: 10.1107/S1744309113023877. Epub 2013 Sep 28.
Bacteroides thetaiotaomicron BT0793, a putative xylose isomerase, was overexpressed in Escherichia coli, purified and crystallized using polyethylene glycol monomethyl ether 550 as the precipitant. X-ray diffraction data were collected to 2.10 Å resolution at 100 K using synchrotron X-rays. The
PMID 24100564

Differences in the Substrate Specificities and Active-Site Structures of Two α-L-Fucosidases (Glycoside Hydrolase Family 29) from Bacteroides thetaiotaomicron

SAKURAMA Haruko,TSUTSUMI Erika,ASHIDA Hisashi [他],KATAYAMA Takane,YAMAMOTO Kenji,KUMAGAI Hidehiko
Bioscience, biotechnology, and biochemistry 76(5), 1022-1024, 2012-05-23
Recent studies suggest that α-L-fucosidases of glycoside hydrolase family 29 can be divided into two subfamilies based on substrate specificity and phylogenetic clustering. To explore the validity of …
NAID 10030753211

Bacteroides uniformis as the dominant bacterial species involved in activation of ginseng protopanaxadiol saponins in human intestines

長谷川秀夫,SAKAMOTO Mitsuo,Benno Yoshimi
和漢医薬学雑誌 24(4), 140-143, 2007-08-20
漢方処方を構成する生薬には様々な配糖体が有効成分として含まれる。配糖体は加水分解されてから吸収され,薬効を発揮する。この加水分解には,腸内細菌が深く関与している。腸内細菌叢の構成は個体差が大きく,配糖体を加水分解する能力を有する腸内細菌の有無が,薬効差を引き起こす一因になることが懸念される。そこで著者らは,人参(Panax ginseng C. A. MEYER)を例にとり,人参配糖体(サポニン) …
NAID 110006367502

境雄大,佐藤浩一,長谷川善枝,木村由佳,須藤泰裕,小柳雅是,田中正則
日本消化器外科学会雑誌 39(9), 1559-1564, 2006-09-01
… 存的治療を行った.翌日,腹膜刺激症状と炎症反応を認め,当科に入院した.急性虫垂炎による汎発性腹膜炎を疑い,手術を行った.虫垂腫大と骨盤腔内の膿性腹水を認め,虫垂切除術を行った.腹水からBacteroides thetaiotaomicronが検出された.摘出虫垂粘膜に炎症を認めなかった.高CEA血症と貧血を認めたため,消化管精査を行い,上行結腸癌が発見された.23日目に結腸右半切除術を行った.腫瘍の穿孔,膿瘍形成を認めなかった.腫瘍は高 …
NAID 110004793279