WordNet

an impairment of health or a condition of abnormal functioning
caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological

PrepTutorEJDIC

(体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
女性の話術芸人 =diseur
病気にかかった / 病的な,不健全な(morbid)

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1. 原発性副腎不全（アジソン病）の原因 causes of primary adrenal insufficiency addisons disease
2. 成人における副腎不全の診断 diagnosis of adrenal insufficiency in adults
3. 成人における副腎不全の臨床症状 clinical manifestations of adrenal insufficiency in adults
4. 小児における副腎不全の診断 diagnosis of adrenal insufficiency in children
5. 成人における二次性および三次性副腎不全の原因 causes of secondary and tertiary adrenal insufficiency in adults

English Journal

Clinical and genetic aspects in twelve korean patients with adrenomyeloneuropathy.

Park HJ1, Shin HY2, Kang HC3, Choi BO4, Suh BC5, Kim HJ6, Choi YC2, Lee PH2, Kim SM2.Author information 1Department of Neurology, Ewha Womans University School of Medicine, Seoul, Korea. ; Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.2Department of Neurology, Yonsei University College of Medicine, Seoul, Korea.3Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.4Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.5Department of Neurology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.6Department of Neurology, Research Institute and Hospital of National Cancer Center, Goyang, Korea.AbstractPURPOSE: This study was designed to investigate the characteristics of Korean adrenomyeloneuropathy (AMN) patients.
Yonsei medical journal.Yonsei Med J.2014 May 1;55(3):676-82. doi: 10.3349/ymj.2014.55.3.676. Epub 2014 Apr 1.
PURPOSE: This study was designed to investigate the characteristics of Korean adrenomyeloneuropathy (AMN) patients.MATERIALS AND METHODS: We retrospectively selected 12 Korean AMN patients diagnosed by clinical analysis and increased plasma content of very long chain fatty acids.RESULTS: All 12 pati
PMID 24719134

Deep Brain Stimulation and Dantrolene for Secondary Dystonia in X-Linked Adrenoleukodystrophy.

van Karnebeek C1, Horvath G, Murphy T, Purtzki J, Bowden K, Sirrs S, Honey CR, Stockler S.Author information 1Division of Biochemical Diseases, Department of Pediatrics, BC Children's Hospital, Vancouver, BC, V5Z 1M9, Canada.AbstractDeep brain stimulation (DBS) has been used to treat secondary dystonias caused by inborn errors of metabolism with varying degrees of effectiveness. Here we report for the first time the application of DBS as treatment for secondary dystonia in a 22-year-old male with X-linked adrenoleukodystrophy (X-ALD). The disease manifested at age 6 with ADHD, tics, and dystonic gait, and deteriorated to loss of ambulation by age 11, and speech difficulties, seizures, and characteristic adrenal insufficiency by age 16. DBS in the globus pallidus internus was commenced at age 18. However, after 25 months, no improvement in dystonia was observed (Burke-Fahn-Marsden (BFM) scores of 65.5 and 62 and disability scores of 28 and 26, pre- and post-DBS, respectively) and the DBS device was removed. Treatment with dantrolene reduced skeletal muscle tone and improved movement (Global Dystonia Rating Scores from 5 to 1 and BFM score 42). Therefore, we conclude that DBS was a safe but ineffective intervention in our case with long-standing dystonia, whereas treatment of spasticity with dantrolene did improve the movement disorder in this young man with X-ALD.
JIMD reports.JIMD Rep.2014 Apr 10. [Epub ahead of print]
Deep brain stimulation (DBS) has been used to treat secondary dystonias caused by inborn errors of metabolism with varying degrees of effectiveness. Here we report for the first time the application of DBS as treatment for secondary dystonia in a 22-year-old male with X-linked adrenoleukodystrophy (
PMID 24718842

Small nerve fiber involvement is frequent in X-linked adrenoleukodystrophy.

Horn MA1, Nilsen KB, Jørum E, Mellgren SI, Tallaksen CM.Author information 1From the Department of Neurology (M.A.H., E.J., C.M.E.T., K.B.N.), Oslo University Hospital; University of Oslo (M.A.H., E.J., C.M.E.T.); Department of Neuroscience (K.B.N.), Norwegian University of Science and Technology, Trondheim; Department of Neurology (S.I.M.), University Hospital of Northern Norway; and Department of Clinical Medicine (S.I.M.), UiT The Arctic University of Norway.AbstractOBJECTIVE: To investigate the presence of small nerve fiber dysfunction in subjects with X-linked adrenoleukodystrophy.
Neurology.Neurology.2014 Apr 9. [Epub ahead of print]
OBJECTIVE: To investigate the presence of small nerve fiber dysfunction in subjects with X-linked adrenoleukodystrophy.METHODS: Cross-sectional study in which 11 Norwegian subjects (3 males, 8 females) with X-linked adrenoleukodystrophy, phenotypes ranging from asymptomatic to wheelchair-bound with
PMID 24719486