ADP-glucose pyrophosphorylase

ADPグルコースピロホスホリラーゼ

関

glucose-1-phosphate adenylyltransferase

WordNet

1. the 1st letter of the Roman alphabet (同)a
2. the blood group whose red cells carry the A antigen (同)type_A, group A
3. a monosaccharide sugar that has several forms; an important source of physiological energy
4. in the Christian era; used before dates after the supposed year Christ was born; "in AD 200" (同)A.D., anno_Domini

PrepTutorEJDIC

1. answer / ampere
2. ブドウ糖

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/16 21:33:02」(JST)

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[Wiki en表示]

glucose-1-phosphate adenylyltransferase
Identifiers
EC number	2.7.7.27
CAS number	9027-71-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, a glucose-1-phosphate adenylyltransferase (EC 2.7.7.27) is an enzyme that catalyzes the chemical reaction

ATP + alpha-D-glucose 1-phosphate diphosphate + ADP-glucose

Thus, the two substrates of this enzyme are ATP and alpha-D-glucose 1-phosphate, whereas its two products are diphosphate and ADP-glucose.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:alpha-D-glucose-1-phosphate adenylyltransferase. Other names in common use include ADP glucose pyrophosphorylase, glucose 1-phosphate adenylyltransferase, adenosine diphosphate glucose pyrophosphorylase, adenosine diphosphoglucose pyrophosphorylase, ADP-glucose pyrophosphorylase, ADP-glucose synthase, ADP-glucose synthetase, ADPG pyrophosphorylase, ADP:alpha-D-glucose-1-phosphate adenylyltransferase and AGPase. This enzyme participates in starch and sucrose metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1YP2, 1YP3, and 1YP4.

References

• Ghosh HP, Preiss J (1966). "Adenosine diphosphate glucose pyrophosphorylase. A regulatory enzyme in the biosynthesis of starch in spinach leaf chloroplasts". J. Biol. Chem. 241 (19): 4491–504. PMID 5922972. 
• Shen L and Preiss J (1965). "Biosynthesis of bacterial glycogen. I. Purification and properties of the adenosine diphosphoglucose pyrophosphorylase of Arthrobacter species NRRL B1973". J. Biol. Chem. 240: 2334–2340. 

UpToDate Contents

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• 1. 成人糖尿病患者のマネージメントにおける血糖の自己モニタリング（SMBG） blood glucose self monitoring in management of adults with diabetes mellitus
• 2. 乳児および小児における低血糖に対するアプローチ approach to hypoglycemia in infants and children
• 3. グルコース-6-リン酸脱水素酵素欠損症の診断および治療 diagnosis and treatment of glucose 6 phosphate dehydrogenase deficiency
• 4. グルコース-6-リン酸脱水素酵素欠損症の臨床症状 clinical manifestations of glucose 6 phosphate dehydrogenase deficiency
• 5. 2型糖尿病のスクリーニング screening for type 2 diabetes mellitus

English Journal

• Simultaneous boosting of source and sink capacities doubles tuber starch yield of potato plants.

• Jonik C, Sonnewald U, Hajirezaei MR, Flügge UI, Ludewig F.SourceCologne Biocenter, Botanical Institute II, University of Cologne, Cologne, Germany.
• Plant biotechnology journal.Plant Biotechnol J.2012 Dec;10(9):1088-98. doi: 10.1111/j.1467-7652.2012.00736.x. Epub 2012 Aug 29.
• An important goal in biotechnological research is to improve the yield of crop plants. Here, we genetically modified simultaneously source and sink capacities in potato (Solanum tuberosum cv. Desirée) plants to improve starch yield. Source capacity was increased by mesophyll-specific overexpression
• PMID 22931170

• Insights into Glycogen Metabolism in Chemolithoautotrophic Bacteria from Distinctive Kinetic and Regulatory Properties of ADP-Glucose Pyrophosphorylase from Nitrosomonas europaea.

• Machtey M, Kuhn ML, Flasch DA, Aleanzi M, Ballicora MA, Iglesias AA.SourceLaboratorio de Enzimología Molecular, Instituto de Agrobiotecnología del Litoral (UNL-CONICET), FBCB-UNL, Santa Fe, Argentina.
• Journal of bacteriology.J Bacteriol.2012 Nov;194(22):6056-65. doi: 10.1128/JB.00810-12. Epub 2012 Sep 7.
• Nitrosomonas europaea is a chemolithoautotroph that obtains energy by oxidizing ammonia in the presence of oxygen and fixes CO(2) via the Benson-Calvin cycle. Despite its environmental and evolutionary importance, very little is known about the regulation and metabolism of glycogen, a source of carb
• PMID 22961847

Japanese Journal

• Isolation and characterisation of the ADP-glucose pyrophosphorylase small subunit gene (AgpS1) promoter in tomato (Solanum lycopersicum L.)

• Goto Yukihisa,Nonaka Satoko,Yin Yong-Gen,Koiwa Teruyuki,Asamizu Erika,Ezura Hiroshi,Matsukura Chiaki
• Plant Biotechnology, 2013
• … ADP-glucose pyrophosphorylase (AGPase) is a key regulatory enzyme in starch biosynthesis. …
• NAID 130003362437

• Modulation of Allosteric Regulation by E38K and G101N Mutations in the Potato Tuber ADP-glucose Pyrophosphorylase

• WAKUTA Shinji,SHIBATA Yumi,YOSHIZAKI Yumiko,SABURI Wataru,HAMADA Shigeki,ITO Hiroyuki,HWANG Seon-Kap,OKITA Thomas W.,MATSUI Hirokazu
• Bioscience, Biotechnology, and Biochemistry, 2013
• … The higher plant ADP-glucose (ADPG) pyrophosphorylase (AGPase), composed of two small subunits and two large subunits (LSs), produces ADPG, the sole substrate for starch biosynthesis from α-D-glucose 1-phosphate and ATP. …
• NAID 130003361219

• Post-Translational Redox Modification of ADP-Glucose Pyrophosphorylase in Response to Light is Not a Major Determinant of Fine Regulation of Transitory Starch Accumulation in Arabidopsis Leaves

• Li Jun,Almagro Goizeder,Munoz Francisco Jose [他],BAROJA-FERNANDEZ Edurne,BAHAJI Abdellatif,MONTERO Manuel,HIDALGO Maite,SANCHEZ-LOPEZ Angela Maria,EZQUER Ignacio,SESMA Maria Teresa,POZUETA-ROMERO Javier
• Plant and cell physiology 53(2), 433-444, 2012-02-01
• NAID 10030308891

Related Links

• 糖質科学のことば / Saccharide-C03J

2000年12月15日 ... ADPglucose は、細菌のグリコーゲン生合成や植物のデンプン生合成において、ATPと glucose-1-phosphate から合成されたのち、グルコース供与体として用いられる。この 反応を触媒するのが、ADPglucose pyrophosphorylase (EC ...

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★リンクテーブル★

リンク元	「ADPグルコースピロホスホリラーゼ」「glucose-1-phosphate adenylyltransferase」「ADP-グルコースピロホスホリラーゼ」
関連記事	「ADP」「A」「AD」「pyrophosphorylase」

「ADPグルコースピロホスホリラーゼ」

　　[★]

英

ADP-glucose pyrophosphorylase

関

グルコース-1-リン酸アデニリルトランスフェラーゼ、ADP-グルコースピロホスホリラーゼ

「glucose-1-phosphate adenylyltransferase」

　　[★]

グルコース-1-リン酸アデニリルトランスフェラーゼ

関

ADP-glucose pyrophosphorylase

「ADP-グルコースピロホスホリラーゼ」

　　[★]

英

ADP-glucose pyrophosphorylase

関

ADPグルコースピロホスホリラーゼ

「ADP」

　　[★]

• アデノシン二リン酸 adenosine diphosphate adenosine 5'-diphosphate
• 5-aminolevulinic acid dehydratase porphyria
• 母指内転筋 adductor pollicis

「A」

　　[★]

• アデニン adenine
• アデノシン adenosine
• アラニン alanine

　 　 　

「AD」

　　[★]

• atopic dermatitis
• advance directives

　

「pyrophosphorylase」

　　[★] ピロホスホリラーゼ