14-membered macrolide

14員環系マクロライド

WordNet

1. anything that belongs to a set or class; "snakes are members of the class Reptilia"; "members of the opposite sex"
2. one of the persons who compose a social group (especially individuals who have joined and participate in a group organization); "only members will be admitted"; "a member of the faculty"; "she was introduced to all the members of his family" (同)fellow member
3. an organization that is a member of another organization (especially a state that belongs to a group of nations); "the library was a member of the interlibrary loan association"; "Canada is a member of the United Nations"
4. having members; normally used in chemistry in combination with a number

PrepTutorEJDIC

1. (集団の)『一員』,会員,メンバー《+『of』+『名』》 / 《またM-》国会議員 / (数式の)項,辺 / 《文》身体の一部;(特に)手,足 / 《遠回しに》男根

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• 1. アジスロマイシン、クラリスロマイシン、およびテリスロマイシン azithromycin clarithromycin and telithromycin
• 2. マクロライド系剤、アミノグリコシド、テトラサイクリン、クリンダマイシン、およびメトロニダゾールに対する過敏反応 hypersensitivity reactions to macrolides aminoglycosides tetracyclines clindamycin and metronidazole
• 3. マクロライド系剤、アザライド系剤、リンコサミン系剤、およびケトライド系剤に対する肺炎レンサ球菌の耐性 resistance of streptococcus pneumoniae to the macrolides azalides lincosamines and ketolides
• 4. 小児における黄色ブドウ球菌菌血症：マネージメントおよび転帰 staphylococcus aureus bacteremia in children management and outcome
• 5. 嚢胞性線維症：肺疾患治療の概要 cystic fibrosis overview of the treatment of lung disease

English Journal

• Total synthesis and structural revision of sekothrixide.

• Terayama N1, Yasui E, Mizukami M, Miyashita M, Nagumo S.
• Organic letters.Org Lett.2014 Jun 6;16(11):2794-7. doi: 10.1021/ol5006856. Epub 2014 May 20.
• The first total synthesis of 14-membered macrolide sekothrixide and the originally proposed structure are reported. Seven contiguous asymmetric centers in the side chain were constructed using ring-openings of several kinds of epoxide. Assembly of the left segment and right segment was performed on
• PMID 24840852

• Polymorphic transformation of antibiotic clarithromycin under acidic condition.

• Noguchi S1, Takiyama K, Fujiki S, Iwao Y, Miura K, Itai S.
• Journal of pharmaceutical sciences.J Pharm Sci.2014 Feb;103(2):580-6. doi: 10.1002/jps.23825. Epub 2013 Dec 20.
• Clarithromycin (CAM) is a 14-membered semisynthetic macrolide antibiotic used to treat the infection of various bacteria including Helicobacter pylori. The polymorphic transformation of CAM form II crystals under acidic conditions is, however, still unclear, and was investigated using X-ray powder d
• PMID 24375227

• Callyspongiolide, a cytotoxic macrolide from the marine sponge Callyspongia sp.

• Pham CD1, Hartmann R, Böhler P, Stork B, Wesselborg S, Lin W, Lai D, Proksch P.
• Organic letters.Org Lett.2014 Jan 3;16(1):266-9. doi: 10.1021/ol403241v. Epub 2013 Dec 13.
• A novel macrolide, callyspongiolide, whose structure was determined by comprehensive analysis of the NMR and HRMS spectra, was isolated from the marine sponge Callyspongia sp. collected in Indonesia. The compound features a carbamate-substituted 14-membered macrocyclic lactone ring with a conjugated
• PMID 24329175

Japanese Journal

• A 14-Membered Macrolide and Isocoumarin Derivatives from the Cultured Lichen Mycobionts of Graphis vestitoides

• , , [他], ,
• Chemical and Pharmaceutical Bulletin 61(3), 358-362, 2013
• … The investigation of their metabolites resulted in isolation of a novel 14-membered macrolide and a new isocoumarin, together with five known isocoumarin derivatives. … This is the first instance of isolation of a 14-membered macrolide from a lichen mycobiont. …
• NAID 130002460116

• Protective Effects of Clarithromycin, a Lipophilic 14-membered Macrolide, on Hemolysis Induced by Lysophosphatidylcholine in Human Erythrocytes

• , , , , ,
• 医療薬学 38(10), 617-627, 2012
• … We examined the effects of 8 macrolide antimicrobial agents, including 14-, 15- and 16-membered ring lactone and ketoride derivatives, on hemolysis induced by lysophosphatidylcholine (LPC) in human erythrocytes. … However, rokitamycin was not effective, although it is more lipophilic than clarithromycin, indicating that factors other than high lipophilicity are responsible for the protective effects of macrolide antimicrobial agents against LPC-induced hemolysis. …
• NAID 130004502711

• ロイコマイシン類を出発物質としたラクトンの化学変換と新規アザライドの創出

• 三浦 知明,兼本 憲一,味戸 慶一
• 有機合成化学協会誌 69(12), 1339-1351, 2011-12-01
• … For the purpose of generation of a new macrolide antibiotic which is effective against constitutive erm-resistant Streptococcus pneumoniae, a variety of novel 11-azalides were designed and synthesized starting from 16-membered macrolides, leucomycins. … One step macrocyclization by a linear dialdehyde and a primary amine via reductive amination firstly gave 15-membered 11-azalide, and optimized 11-N-arylalkyl-azalide was effective against inducible erm-resistant S. …
• NAID 10030480355

Related Links

• Comparative in vitro activities of new 14-, 15-, and 16 ...

Abstract The in vitro activities of several 14-, 15- and 16-membered macrolides were compared with that of erythromycin. In general, 14-membered macrolides such as erythromycin, clarithromycin, and flurithromycin were ...

• Roxithromycin and clarithromycin, 14-membered ring ...

1. Cancer Lett. 1999 Dec 1;147(1-2):17-24. Roxithromycin and clarithromycin, 14-membered ring macrolides, potentiate the antitumor activity of cytotoxic agents against mouse B16 melanoma cells. Yatsunami J, Fukuno ...

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関連記事	「macrolide」「macrolides」「member」

「macrolide」

　　[★] マクロライド、大環状化合物、(薬剤)マクロライド系薬、マクロライド系抗生物質、マクロライド系抗菌薬、マクロライド系の

関

macrocyclic compound、macrolide antibiotic、MLSB耐性

「macrolides」

　　[★] マクロライド系抗菌薬

「member」

　　[★]

• メンバー