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1. 嚢胞性線維症：消化器疾患の概要cystic fibrosis overview of gastrointestinal disease [show details]
… measured by fecal elastase) and many children reached a fecal elastase level consistent with pancreatic sufficiency . Other studies suggest that the pancreatic exocrine dysfunction may be less reversible with …
2. のう胞性線維症：CFTR調整薬cystic fibrosis treatment with cftr modulators [show details]
… showed improvement in exocrine pancreatic function . Increase in fecal elastase was also seen in older patients who were pancreatic sufficient at baseline .… and repaglinide because it is an inhibitor of the organic anion-transporting polypeptide (OATP) 1B1 and 1B3.… is called a "gating mutation" because it impairs the regulated opening of the ion channel that is formed by the CFTR protein.…
3. 開発途上国の小児における持続性下痢persistent diarrhea in children in resource limited countries [show details]
… used fecal elastase-1 to identify pancreatic exocrine insufficiency in 31 children with persistent diarrhea with or without malnutrition and randomized them to treatment with pancreatic enzyme replacement… diarrhea) occurs when pathogens produce toxins that stimulate small intestinal secretion of chloride ions,with concomitant fluid movement into the intestinal lumen that overwhelms the absorptive capacity …
4. 嚢胞性線維症：遺伝学と病因cystic fibrosis genetics and pathogenesis [show details]
… Impaired flow of bile and pancreatic secretions cause maldigestion and malabsorption, as well as progressive liver and pancreatic disease,… the rate of ion flow and the duration of channel opening are reduced when compared with normal CFTR function.… infiltration of these inflammatory cells into the lung tissue . Recruited neutrophils subsequently release elastase, which overwhelms the antiproteases of the lung and contributes to tissue destruction in a process …
5. 膵外分泌機能不全exocrine pancreatic insufficiency [show details]
… direct correlation in pancreatic elastase-1 concentrations in pancreatic fluid and stool . Fecal elastase-1 <200 mcg/g is considered abnormal. The sensitivity of fecal elastase-1 for mild, moderate, and …