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1. 低リスクおよび極めて低リスクの臨床的限局性前立腺癌に対する初回のアプローチinitial approach to low and very low risk clinically localized prostate cancer [show details]
… most men with very low-risk or low-risk prostate cancer and a reasonable life expectancy in the absence of certain histologic features (areas of cribriform or intraductal cancer) and low-risk gene expression …
2. 成人の軽症クローン病（低リスク）への内科的マネージメントの概要overview of the medical management of mild low risk crohn disease in adults [show details]
… Prednisone can be given to low-risk patients who do not respond to budesonide; however, patients who initially respond to oral glucocorticoids but cannot tolerate gradual tapering of prednisone are no …
3. テストステロン低下症の高齢男性へのアプローチapproach to older men with low testosterone [show details]
… As men age, their serum concentrations of testosterone decrease. This decline is gradual and of a modest degree, but because many of the changes of aging are similar to those of hypogonadism due to known …
4. ストレス骨折の概要overview of stress fractures [show details]
… restricted by the pain of arthritis who resumes walking after joint replacement surgery . Decreased physical fitness – Decreased muscle strength and endurance are associated with an increased incidence of stress …
5. 小児のチアノーゼへの治療アプローチapproach to cyanosis in children [show details]
… Exposures – Smoke inhalation or exposure to other low oxygen environments suggests central cyanosis from decreased inspired oxygen.… Raynaud phenomenon (RP) is a specific type of acrocyanosis that causes white,…

Japanese Journal

反復神経刺激法 (神経生理検査up to date)

畑中裕己
臨床病理 = The official journal of Japanese Society of Laboratory Medicine : 日本臨床検査医学会誌 67(7), 744-751, 2019-07
NAID 40021997744

ニボルマブ投与後に発症した筋炎合併重症筋無力症の1剖検例

澤井大樹,細川隆史,重清太郎,小川将司,佐野恵理,荒若繁樹
臨床神経学 59(6), 360-364, 2019
… <p>症例は84歳女性．腎細胞癌に対しニボルマブが投与された13日後より複視，眼瞼下垂，四肢脱力，嚥下障害が出現し，高CK血症を伴った．塩酸エドロフォニウム試験及び反復刺激検査での漸減現象から重症筋無力症と診断した．抗アセチルコリン受容体抗体は陰性であった．IVIg及びステロイドの投与にてCK値は正常化したが，身体症状は改善せず，呼吸不全で死亡された．剖検にて，腸腰筋と横隔膜の筋線維周囲に …
NAID 130007666298