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1. 先天性赤血球増多症および真性多血症の分子学的病因molecular pathogenesis of congenital polycythemic disorders and polycythemia vera [show details]
…established molecular lesions due to germline mutations that either modify hemoglobin oxygen affinity or modify the normal response to hypoxia will be discussed here. Current understanding of the molecular pathogenesis… The CP gene was localized by positional cloning to a mutation of the von Hippel-Lindau (VHL) gene…
2. 組換え造血成長因子の概要introduction to recombinant hematopoietic growth factors [show details]
…exposure of progenitor cells to CSFs having different lineage specificities . Following the molecular cloning of the genes for many of these factors and their receptors during the 1980s and 1990s, it became …
3. 副腎ステロイド生合成adrenal steroid biosynthesis [show details]
…intermediary, to molecular oxygen with concomitant oxygenation of a number of substrates. The nomenclature of these enzymes has been changed as a result of insights gained from molecular cloning. The current…
4. ビタミンKおよびその合成ならびにガンマカルボキシグルタミン酸の機能vitamin k and the synthesis and function of gamma carboxyglutamic acid [show details]
…integral membrane protein, requiring carbon dioxide, molecular oxygen, and the hydroquinone form of vitamin K to convert Glu residues to Gla . Molecular cloning of the human and bovine vitamin K-dependent carboxylase …
5. 遺伝学およびゲノミクスのためのツール：研究用に育種された遺伝子改変マウスtools for genetics and genomics specially bred and genetically engineered mice [show details]
…used to construct them. Fundamental to all such experiments is the ability to carry out molecular cloning and molecular biological manipulations . Specific methods used to introduce engineered DNA into mice …