WordNet
- an impairment of health or a condition of abnormal functioning
- caused by or altered by or manifesting disease or pathology; "diseased tonsils"; "a morbid growth"; "pathologic tissue"; "pathological bodily processes" (同)morbid, pathologic, pathological
PrepTutorEJDIC
- (体の)『病気』,疾患 / (精神・道徳などの)病気,病弊
- 女性の話術芸人 =diseur
- 病気にかかった / 病的な,不健全な(morbid)
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- 1. 成人における再発性および難治性の急性リンパ芽球性白血病の治療 treatment of relapsed or refractory acute lymphoblastic leukemia in adults
- 2. 再発性および難治性の急性前骨髄球性白血病の治療 treatment of relapsed or refractory acute promyelocytic leukemia in adults
- 3. 孤立性髄外性形質細胞腫の診断およびマネージメント diagnosis and management of solitary extramedullary plasmacytoma
- 4. 再発性または難治性の急性骨髄性白血病の治療 treatment of relapsed or refractory acute myeloid leukemia
- 5. サラセミアの臨床症状および診断 clinical manifestations and diagnosis of the thalassemias
English Journal
- Spinal cord tumors: new views and future directions.
- Mechtler LL, Nandigam K.SourceDent Imaging and Neuro-Oncology Center, Dent Neurologic Institute, 3980 Sheridan Drive, Buffalo, NY 14226, USA; Roswell Park Cancer Institute, Buffalo, NY, USA; American Society of Neuro-Imaging, Minneapolis, MN, USA. Electronic address: lmechtler@dentinstitute.com.
- Neurologic clinics.Neurol Clin.2013 Feb;31(1):241-68. doi: 10.1016/j.ncl.2012.09.011.
- Spinal cord tumors are uncommon neoplasms that, without treatment, can cause significant neurologic morbidity and mortality. The historic classification of spine tumors is based on the use of myelography with 3 main groups: (1) extramedullary extradural, (2) intradural extramedullary, and (3) intrad
- PMID 23186903
- Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice.
- Chang T, Krisman K, Theobald EH, Xu J, Akutagawa J, Lauchle JO, Kogan S, Braun BS, Shannon K.AbstractChildren with neurofibromatosis type 1 (NF1) are predisposed to juvenile myelomonocytic leukemia (JMML), an aggressive myeloproliferative neoplasm (MPN) that is refractory to conventional chemotherapy. Conditional inactivation of the Nf1 tumor suppressor in hematopoietic cells of mice causes a progressive MPN that accurately models JMML and chronic myelomonocytic leukemia (CMML). We characterized the effects of Nf1 loss on immature hematopoietic populations and investigated treatment with the MEK inhibitor PD0325901 (hereafter called 901). Somatic Nf1 inactivation resulted in a marked expansion of immature and lineage-committed myelo-erythroid progenitors and ineffective erythropoiesis. Treatment with 901 induced a durable drop in leukocyte counts, enhanced erythropoietic function, and markedly reduced spleen sizes in mice with MPN. MEK inhibition also restored a normal pattern of erythroid differentiation and greatly reduced extramedullary hematopoiesis. Remarkably, genetic analysis revealed the persistence of Nf1-deficient hematopoietic cells, indicating that MEK inhibition modulates the proliferation and differentiation of Nf1 mutant cells in vivo rather than eliminating them. These data provide a rationale for performing clinical trials of MEK inhibitors in patients with JMML and CMML.
- The Journal of clinical investigation.J Clin Invest.2013 Jan 2;123(1):335-9. doi: 10.1172/JCI63193. Epub 2012 Dec 10.
- Children with neurofibromatosis type 1 (NF1) are predisposed to juvenile myelomonocytic leukemia (JMML), an aggressive myeloproliferative neoplasm (MPN) that is refractory to conventional chemotherapy. Conditional inactivation of the Nf1 tumor suppressor in hematopoietic cells of mice causes a progr
- PMID 23221337
Japanese Journal
- 臨床室 結晶沈着を伴う腰椎硬膜内髄外石灰化病変の1例
- 貝澤 幸俊,大西 英次郎,松下 睦
- 整形外科 63(1), 26-29, 2012-01
- NAID 40019150869
- 胃と直腸に髄外性病変を認めた多発性骨髄腫の1例
- 望月 洋介,齋藤 康晴,稲富 理,小泉 祐介,馬場 重樹,仲原 民夫,辻川 知之,石田 光明,安藤 朗,藤山 佳秀
- 日本消化器内視鏡学会雑誌 = Gastroenterological endoscopy 53(3), 1090-1096, 2011-03-20
- 症例は70歳代前半男性．腰痛を伴う高蛋白血症，高Ca血症，腎機能障害にて当院紹介受診．多発性骨髄腫と診断され化学療法にて寛解となるも，半年後に腹痛，腹満感が出現．腹部CTにて肝右葉に腫瘤を，また上部下部消化管内視鏡にて直腸および胃病変を認め，各々生検にて骨髄腫髄外病変と診断した．その後化学療法の反応乏しく，約5カ月後に死亡した．多発性骨髄腫の消化管髄外性病変は稀であり，本例では胃と直腸に認めたため …
- NAID 10028053286
Related Links
- In acute promyelocytic leukemia (APL), extramedullary disease (EMD) is particularly rare and shows special clinical and biological features. It is estimated that about 3–5% of APL patients will suffer extramedullary ...
- News and information about extramedullary disease for multiple myeloma patients, caregivers, and others interested in extramedullary disease and multiple myeloma. ... A recent Greek study highlights the distinct symptoms and ...
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| 関連記事 | 「disease」「extramedullary」 |
「disease」
- n.
- 疾患：illnessより厳密な概念。「ある臓器に明確な障害が確認され、それによって症状が出ているとはっきり説明できる場合」 (PSY.9)
- 特定の原因、病態生理、症状、経過、予後、病理組織所見が全てそろった場合 (PSY.9)
- something that is very wrong with people's attitudes, way of life or with society.
- 注意
「extramedullary」
- 髄外の、骨髄外の