vanillylmandelic acid

出典: meddic

バニリルマンデル酸 VMA

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/06/11 11:46:57」(JST)

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英文文献

  • Pheochromocytoma presenting with remote bony recurrence twenty years after initial surgery: detection with 68Ga-DOTANOC PET/CT.
  • Parida GK1, Dhull VS, Sharma P, Bal C, Kumar R.Author information 1From the Department of Nuclear Medicine, All India Institute of Medical sciences, New Delhi, India.AbstractPheochromocytomas are rare tumors which can be malignant in 10% of cases. We present the case of a 75-year-old woman who presented with headache and palpitation for 1 year. She had a past history of right adrenalectomy for pheochromocytoma 20 years back. In between, the patient was asymptomatic. Twenty-four-hour urinary vanillylmandelic acid was raised. Noncontrast CT and ultrasound of abdomen were unremarkable. The patient underwent 68Ga-DOTANOC PET/CT that showed metastasis to left ilium, which was confirmed on biopsy.
  • Clinical nuclear medicine.Clin Nucl Med.2014 Apr;39(4):365-6. doi: 10.1097/RLU.0b013e31828e98f0.
  • Pheochromocytomas are rare tumors which can be malignant in 10% of cases. We present the case of a 75-year-old woman who presented with headache and palpitation for 1 year. She had a past history of right adrenalectomy for pheochromocytoma 20 years back. In between, the patient was asymptomatic. Twe
  • PMID 23640231
  • Monoamine metabolites in ventricular CSF of children with posterior fossa tumors: correlation with tumor histology and cognitive functioning.
  • Varela M1, Alexiou GA, Liakopoulou M, Papakonstantinou E, Pitsouni D, Alevizopoulos GA.Author information 1Department of Neurosurgery.AbstractObject The biogenic amines (dopamine, epinephrine, norepinephrine, and serotonin) are involved in the regulation of multiple neuronal functions, and changes in monoamine concentrations in the CSF have been detected in several disorders. The aim of the present study was to investigate the role of biogenic amines in the ventricular CSF of children suffering from posterior fossa tumors and their possible correlation with tumor histology and cognitive functioning. Methods Twenty-two children with posterior fossa tumors who were treated surgically at Children's Hospital "Agia Sofia" were studied. Patients ranged in age from 5.5 to 15 years. The study population included patients who suffered from hydrocephalus and were treated by ventriculoperitoneal shunt placement. During the operation for shunt placement, a CSF sample was obtained for the assessment of 3-methoxy-4-hydroxyphenylglycol (MHPG), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA). Simultaneously, a blood sample was also obtained for assessment of the same metabolites in the serum. The concentration of vanillylmandelic acid (VMA) was evaluated in 24-hour urine samples in 11 patients. Cerebrospinal fluid from a control group of children was also studied. Executive functions were assessed using the short form of the Wechsler Intelligence Scale for Children (WISC). Results Twelve patients suffered from astrocytomas, 9 from medulloblastomas, and 1 from an ependymoma. The MHPG concentration in CSF was significantly higher in patients with astrocytomas compared with patients with medulloblastomas. Twenty-four-hour urine samples of VMA were significantly higher in patients with astrocytomas compared with patients with medulloblastomas. The MHPG concentration in CSF was negatively correlated with the verbal scale of the WISC and there was a trend toward a significant negative correlation with the total WISC score. Homovanillic acid in CSF was positively correlated with the performance scale of the WISC. There was a significant correlation between HVA and MHPG levels in CSF. The CSF concentration of 5-HIAA was significantly correlated with the HVA concentration in serum. Twenty-four-hour urine VMA samples were statistically significantly correlated with HVA concentration in both CSF and serum, with MHPG in CSF, and with 5-HIAA in serum. Conclusions This study showed that children with posterior fossa tumors have differences in the levels of monoamine metabolites in CSF. Further studies with a larger number of patients are obviously needed to verify these observations as well as studies to correlate the monoamine metabolite levels with the neuropsychological and behavioral findings in children with posterior fossa tumors.
  • Journal of neurosurgery. Pediatrics.J Neurosurg Pediatr.2014 Apr;13(4):375-9. doi: 10.3171/2014.1.PEDS13425. Epub 2014 Feb 21.
  • Object The biogenic amines (dopamine, epinephrine, norepinephrine, and serotonin) are involved in the regulation of multiple neuronal functions, and changes in monoamine concentrations in the CSF have been detected in several disorders. The aim of the present study was to investigate the role of bio
  • PMID 24559277
  • Diagnostic Challenge of Pheochromocytoma in a Patient Receiving Levodopa for Parkinson's Disease.
  • Shimodaira M, Niwa T, Nakajima K, Kobayashi M, Shimodaira M, Niwa T, Nakajima K, Kobayashi M.Author information The Department of Internal Medicine, Iida Municipal Hospital, Nagano, Japan.AbstractObjective The diagnosis of pheochromocytoma in patients receiving levodopa is challenging because the standard diagnostic biochemical tests are considered to be confounded by dopaminergic therapy. We aim to showcase our experience with the diagnosis of pheochromocytoma in a known case of Parkinson's disease receiving levodopa.Methods We present a case of an elderly male who was diagnosed as pheochromocytoma while receiving dopaminergic therapy for Parkinson's disease.Results A 75 year-old man presented with vague abdominal symptoms. Computed tomography revealed a 3.5 x 3.2-cm right adrenal mass with a well-defined margin. As revealed by magnetic resonance imaging, the mass was hypointense on T1-weighted and hyperintense on T2-weighted images. Biochemical tests revealed elevated levels of urinary dopamine, which was considered to be caused by levodopa therapy. However, the concurrent elevation of urinary adrenaline, and metanephrine, vanillylmandelic acid levels suggested an underlying of pheochromocytoma. 123I-metaiodobenzylguanidine (123I-MIBG) scintigraphy performed under levodopa therapy, showed positive tracer uptake in the right adrenal gland. Histopathology of the adrenalectomy specimen confirmed the diagnosis of pheochromocytoma.Conclusion Our experience with the present case indicates that although the standard diagnostic biochemical tests for pheochromocytoma may be confounded by dopaminergic therapy, 123I-MIBG scintigraphy has diagnostic value for confirming pheochromocytoma even in patients receiving dopaminergic therapy.
  • Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.Endocr Pract.2014 Mar 18:1-14. [Epub ahead of print]
  • Objective The diagnosis of pheochromocytoma in patients receiving levodopa is challenging because the standard diagnostic biochemical tests are considered to be confounded by dopaminergic therapy. We aim to showcase our experience with the diagnosis of pheochromocytoma in a known case of Parkinson's
  • PMID 24641926

和文文献

  • 家族歴にMenkes病を認める新生児3例の臨床像の検討
  • 八木 麻理子,楠 典子,李 知子,粟野 宏之,森岡 一朗,児玉 浩子,竹島 泰弘,飯島 一誠
  • 脳と発達 46(1), 26-29, 2014
  •  【目的】Menkes病 (MD) 早期診断の手がかりを検討する. 【方法】家族歴にMDを認め罹患リスクのある男児3例 (罹患児1例, 非罹患児2例) の新生児期の臨床像を比較した. 【結果】MDに特徴的なkinky hairは, 出生直後は極軽微で見逃す危険性があった. 血清銅は, 罹患児では経時的に低下したが, 非罹患児では上昇した. MDで上昇するとされる尿HVA/VMA比は, 罹患児ではc …
  • NAID 130005005676
  • New semi-quantitative ^<123>I-MIBG estimation method compared with scoring system in follow-up of advanced neuroblastoma : utility of total MIBG retention ratio versus scoring method
  • SANO Yuko,OKUYAMA Chio,IEHARA Tomoko,MATSUSHIMA Shigenori,YAMADA Kei,HOSOI Hajime,NISHIMURA Tsunehiko
  • Annals of nuclear medicine 26(6), 462-470, 2012-07-01
  • NAID 10030949416
  • 傍神経節腫を合併した腎細胞癌の1例
  • 住吉 崇幸,清水 洋祐,井上 貴博 [他]
  • 泌尿器科紀要 57(8), 429-433, 2011-08
  • … A more detailed examination at our hospital revealed elevation of vanillylmandelic acid in urine and 131Imetaiodobenzylguanidine uptake in the tumor. …
  • NAID 40018942640

関連リンク

vanillylmandelic acid [vah-nil″il-man-del´-ik] VMA; the primary end-product of catecholamine metabolism excreted in the urine. Urinary VMA levels are used in screening patients for pheochromocytoma. va·nil·lyl·man·del·ic ac·id (VMA),
vanillylmandelic acid [vah-nil″il-man-del´-ik] VMA; the primary end-product of catecholamine metabolism excreted in the urine. Urinary VMA levels are used in screening patients for pheochromocytoma. va·nil·lyl·man·del·ic ac·id (VMA),

関連画像

for vanillylmandelic acid homovanilic acid Chapter 30: Other Hormones and DisordersCatecholaminergic Systems in Stress Vanilmandelic acid ,Vanillylmandelic acid 18F-Fluorodihydroxyphenylalanine PET vanillylmandelic acid


★リンクテーブル★
リンク元カテコールアミン」「バニリルマンデル酸」「ホモバニリン酸」「バニリルマンデリン酸」「VMA
関連記事acid

カテコールアミン」

  [★]

catecholamine catecholamines CA
カテコラミン
副腎髄質ホルモン
  • カテコールでかつアミンを持つ構造

Wikipedia

生合成

チロシン tyrosine
 (フェニル基の3位にOHを導入) :律速酵素
 -チロシン 3-モノオキシゲナーゼ tyrosine 3-monooxygenase, チロシン水酸化酵素 tyrosine hydroxylase
 ←{H4biopterin}
 →{H2biopterin}
L-ドーパ L-dopa
 (アミノ酸から脱炭酸)
 -芳香族アミノ酸デカルボキシラーゼ dopa decarboxylase + {ピリドキサル5-リン酸(VB6)}
 →CO2
ドパミン dopamine
 (β位の炭素にOHを導入)
 -ドーパミン β-モノオキシゲナーゼ dopamine β-monoxygenase, dopamine β-odidase
 ←O2 + ビタミンC(アスコルビン酸)
 →H2O + デヒドロアスコルビン酸
ノルアドレナリン norepinephrine
 (アミノ基にメチル基を転移)
 -フェニルエタノールアミン N-メチルトランスフェラーゼ phenylethanolamine N-methyl transferase
 ←S-アデノシルメチオニン S-adenosylmethionineS-アデノシルホモシステイン S-adenosylhemocysteine
アドレナリン epinephrine

分解

分解産物

ドパミン
dopamine
---→ ジヒドロキシフェニル酢酸
3,4-dihydroxyphenylacetic acid
DOPAC
---→ ホモバニリン酸
homovanillic acid
HVA

MAO
COMT
     


       
ノルエピネフリン
norepinephrine
---→ バニリルマンデリン酸
vanillylmandelic acid
VMA
       ・
メトキシヒドロキシフェニルグリコール
methoxyhydroxyphenylglycol
MHPG
   


MAO
COMT
   
エピネフリン
epinephrine
---→    
  MAO
COMT
   

薬理作用

昇圧作用






バニリルマンデル酸」

  [★]

vanillylmandelic acid VMA, 3-methoxy-4-hydroxymandelic acid
バニルマンデリン酸 vanilmandelic acid
マンデル酸バニリン酸、ホモバリニン酸


HVA ホモバニリン酸 homovanillic acid ドパミンの代謝産物
VMA バニリルマンデル酸 vanillylmandelic acid ノルアドレナリンアドレナリンの代謝産物



ホモバニリン酸」

  [★]

homovanillic acid, HVA


HVA ホモバニリン酸 homovanillic acid ドパミンの代謝産物
VMA バニリルマンデル酸 vanillylmandelic acid ノルアドレナリンアドレナリンの代謝産物

臨床関連



バニリルマンデリン酸」

  [★]

vanillylmandelic acid, VMA
バニルマンデリン酸, 4-hydroxy-3-methoxymandelic acid
[show details]


VMA」

  [★] バニリルマンデル酸 vanillylmandelic acid


acid」

  [★]

WordNet   license wordnet

「street name for lysergic acid diethylamide」
back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen

WordNet   license wordnet

「any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt」

WordNet   license wordnet

「having the characteristics of an acid; "an acid reaction"」

PrepTutorEJDIC   license prepejdic

「酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD」




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